Association of the IL-1RN variable number of tandem repeat polymorphism and Helicobacter pylori infection: A meta-analysis

Zhang, Jinhua; Sun, Xudong; Wang, Jiemin; Zhang, Fuhua; Li, Xiaohua; Han, Jing

doi:10.1371/journal.pone.0175052

Cited by 4 publications

(6 citation statements)

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“…In this case-control study, we calculated the association of IL1RN polymorphisms with the risk of esophageal IL1RN is a member of the IL-1 cytokine family that modulates a variety of IL-1-related immune and inflammatory responses. Numerous lines of evidence have shown that IL1RN plays a key role in the regulation of cancer pathogenesis and chronic inflammation [20][21][22]. We obtained the expression data for IL1RN from the GEPIA online database (http://gepia.cancer-pku.cn/) (Fig.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, the previous literature has illustrated that the inflammatory response after Helicobacter pylori infection has been linked to the IL-1 gene cluster ( IL-1A , IL-1B , and IL1RN ). A meta-analysis of H. pylori infection performed by Zhang et al [21] demonstrated that IL1RN polymorphisms may increase the risk of H. pylori infection, especially in Asians. Therefore, we can infer that IL1RN polymorphisms may be associated with the risk of esophageal cancer with H. pylori infection.…”

Section: Discussionmentioning

confidence: 99%

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IL1RN Polymorphisms Are Associated with a Decreased Risk of Esophageal Cancer Susceptibility in a Chinese Population

et al. 2019

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Background: Recent evidence suggested that IL1RN (interleukin-1 receptor antagonist) polymorphisms increased the susceptibility to cancers. The present study aimed to evaluate whether IL1RN was related to esophageal cancer susceptibility in a Northwest Han Chinese population. Methods: The case-control study was conducted on 384 esophageal cancer patients and 499 healthy controls. We successfully genotyped four SNPs distributed in IL1RN. The Gene Expression Profiling Interactive Analysis (GEPIA) database was used to observe the expression of IL1RN in esophageal cancer tissues and normal tissues. RegulomeDB and HaploReg v4.1 were used to calculate possible functional effects of the polymorphisms. We also used genetic models to detect any potential association between IL1RN variants and esophageal cancer risk. Results: In our study, rs3181052 was associated with a reduced risk of esophageal cancer in the codominant (odds ratio [OR] = 0.70, 95% confidence interval [CI] 0.52–0.93, p = 0.040), the dominant (OR = 0.75, 95% CI 0.57–0.99, p = 0.041), and the overdominant (OR = 0.71, 95% CI 0.54–0.93, p = 0.012) model. The rs452204 was associated with a 0.76-fold (OR = 0.76, 95% CI 0.58–0.99; p = 0.043) decreased esophageal cancer risk under the overdominant model without adjustment. We also found that rs3181052 had a negative effect on esophageal cancer under the overdominant model (OR = 0.72, 95% CI 0.53–0.97, p = 0.033) adjusted for age and gender. In stratified analyses by age >55 years, rs3181052 reduced the risk of esophageal cancer in the dominant and overdominant models. In addition, rs315919 had a remarkable influence on esophageal cancer risk in females, while the association was not significant between rs3181052 and esophageal cancer risk in males. Conclusions: Our study provided the first evidence that IL1RN rs3181052, rs452204, and rs315919 are correlated with a decreased risk of esophageal cancer in a Northwest Han Chinese population. These findings may be useful for the development of early prognostics for esophageal cancer. However, further larger studies on different ethnic populations are warranted to verify these findings.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

IL1RN Polymorphisms Are Associated with a Decreased Risk of Esophageal Cancer Susceptibility in a Chinese Population

et al. 2019

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“…(31, 38, 47, 48) Since 2000 when Omer et al ., reported the first significant association between gastric cancer risk and polymorphism in the genes IL-1B and IL-1RN among Scottish and Polish patients, (31) a lot of studies from different ethnic groups and populations have pointed out this relation as well. (32, 49, 50) Unfortunately, to the best of our knowledge, no data regarding these polymorphisms are available in Sudan where gastric cancer, according to GLOBOCAN 2018, represents one of the top causing death among cancers with about 686 cases per year and 2.7 % mortality rate. (51) However, most of the studies have observed this association with an IL-1RN 2/2 homozygous genotype (31, 38, 48) but we found this association with a heterozygous genotype ( IL-1RN 2/L) with OR=12.83 (95% CI = 1.261-130.6, P = 0.0302) which is consistent with other studies conducted in Italy, (47, 52) Brazil, (53) Taiwan, (54) China, (55) Turkey (39) and Arabic population (Omani and Algerian) (56, 57) that found the same association of gastric cancer with a IL-1RN 2/L heterozygous genotype.…”

Section: Discussionmentioning

confidence: 99%

“…(13, 30, 31) The most intensively studied IL-1RN polymorphism connected to susceptibility to H. pylori infection and gastric cancer outcome is a penta-allelic 86-bp VNTR (variable number of tandem repeats) polymorphism that is located in intron 2. (12, 32-34) The most typical variants contains four repeats named allele IL1RN*1 and variants with 2 repeats (allele IL1RN*2 ). While other alleles, 3 repeats (allele IL1RN*4 ), 5 repeats ( allele IL1RN*3 ) and 6 repeats ( allele IL1RN*5 ), (35) occur at a combined frequency of <5%.…”

Section: Introductionmentioning

confidence: 99%

“…(36) Studies from different ethnic groups have reported that in individuals infected with H. pylori, IL-1RN*2 allele is associated with increased production of IL-1β which leading to severe and sustained inflammation, gastric atrophy, hypochlorhydria, and ultimately to the development of gastric cancer. (22, 31, 32, 37-39) Contrariwise, Asian studies have been less conclusive on the relation between IL-1RN polymorphism, H. pylori infection and gastric cancer. (40, 41) It seems that there is an ethnic variability with regard to IL-1RN polymorphisms frequency and their association with H. pylori infection and gastric cancer.…”

Section: Introductionmentioning

confidence: 99%

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Independently Carriage ofIL-1RN*2 AlleleAssociated with Increased Risk of Gastric Cancer in The Sudanese Population

Idris

Ataelmanan

Eltaher

et al. 2019

Preprint

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Background: Helicobacter pylori is responsible for gastric cancer in approximately tens of millions of patients. Gastric cancer in Sudan represents one of the top causing death among cancers with about 686 cases per year and a 2.7 % mortality rate. IL-1RN VNTR polymorphism has been reported to increase the risk of gastric cancer. Objective: The purpose of this study was to assess the association of the 86 bp VNTR polymorphism of IL- 1RN gene and the susceptibility to H. pylori infection and gastric cancer in the Sudanese population. Materials and methods: Genomic DNA was extracted from 114 subjects. Of whom 60 had gastritis and duodenitis, 26 had a peptic ulcer, 16 had gastric cancer and 12 had normal gastroscopy findings. H. pylori infection was investigated by specific 16S rRNA. And IL-1RN VNTR polymorphism at intron 2 was genotyped using the PCR method and direct sequencing for random samples. Results: The positive H. pylori infection rate among participants was 47.37%. There is a lack of a significant difference in IL- 1RN genotype with H. pylori infection (p-value=1.0000). The IL-1 RN L/L genotype was significantly more frequent in a patient with benign disorders (gastritis or duodenitis or peptic ulcer), Odd=6.000 (95% CI =1.750-20.57, P=0.0056). While the heterozygote genotype 2/L was associated with an increased risk of gastric cancer with OR = 12.83 (95% CI = 1.261-130.6, P=0.0302). Conclusion: Independently carriage of IL-1RN *2 allele was associated with increased risk of gastric cancer in the Sudanese population. Notwithstanding the relatively small sample size of the study population, our findings show that the host genetic can be a useful tool for identifying high-risk individuals among dyspeptic patients; and also underscore the role played by host genetics in gastric carcinogenesis. To the best of our knowledge, this is the first study in Sudan concerning this issue.

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Interleukin-1β and Interleukin-1 receptor antagonist gene polymorphism in pediatric patients with Helicobacter pylori-associated chronic gastritis

Barakat

Meheissen

El-Gendi

et al. 2021

Journal of Tropical Pediatrics

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Background The severity of Helicobacter pylori infection is determined by the interplay between bacterial virulence, host genetic and environmental factors. This study aimed to identify interleukin-1 beta (IL-1β) and interleukin receptor antagonist (IL-1RN) gene polymorphisms and their associations with H. pylori infection, and severity of chronic gastritis in Egyptian children. Methods A case control study was conducted on 100 children (50 H. pylori positive and 50 controls). Genotyping of IL-1β-31 gene was done by PCR-CTPP (confronting two-pair primers), of IL-1β-511 was performed using allele specific PCR, and investigation of the variable number tandem repeat polymorphism of the IL-1RN gene was done by PCR. Results The genotype C/T of IL1β-511 was the predominant genotype (36/50; 72%) among H. pylori positive cases (p ≤ 0.001). The presence of C/T genotype at position 511 of IL1β was associated with increased risk of infection with H. pylori (p ≤ 0.001, odds ratio = 6.612) and with more severe disease (p = 0.004, odds ratio = 8.333). No association of IL-1β-31 or IL-1RN gene polymorphisms with H. pylori infection or with risk of severe gastric diseases was found. Children who carry two polymorphisms are almost four times at risk for development of H. pylori infection (p = 0.026, odds ratio = 3.937). Conclusions Polymorphism at position -511 of IL1β gene is associated with increased risk of H. pylori infection as well as of severe corpus gastric disease in Egyptian children. This population should be considered a high-risk group, which needs regular gastric endoscopic surveillance, and should be target for H. pylori eradication. Lay summary The genotype C/T of IL1β-511 gene was the predominant genotype (36/50; 72%) among H. pylori positive children. Polymorphism at position -511 of IL1β gene is associated with increased risk of Helicobacter pylori infection as well as of severe corpus gastric disease in Egyptian children. No association of IL-1β-31 or IL-1RN gene polymorphisms with H. pylori infection or with risk of severe gastric diseases in Egyptian children.

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Association of the IL-1RN variable number of tandem repeat polymorphism and Helicobacter pylori infection: A meta-analysis

Cited by 4 publications

References 56 publications

<b><i>IL1RN</i></b> Polymorphisms Are Associated with a Decreased Risk of Esophageal Cancer Susceptibility in a Chinese Population

<b><i>IL1RN</i></b> Polymorphisms Are Associated with a Decreased Risk of Esophageal Cancer Susceptibility in a Chinese Population

Independently Carriage ofIL-1RN*2 AlleleAssociated with Increased Risk of Gastric Cancer in The Sudanese Population

Interleukin-1β and Interleukin-1 receptor antagonist gene polymorphism in pediatric patients with Helicobacter pylori-associated chronic gastritis

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