Epidemiology and Risk Factors for Exocrine Pancreatic Cancer in a Northern African Population

Sellam, Feriel; Harir, Noria; Khaled, Meghit Boumédiène; Mrabent, Nesrine M.; Salah, Rachida; Diaf, Mustapha

doi:10.1007/s12029-015-9693-4

Cited by 11 publications

(10 citation statements)

References 20 publications

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“…The age of pancreatic cancer patients varied between studies. The mean age of our patients was 59 years, which is similar to that reported by Vasen 17,18 . Similar to the findings of other studies [16][17][18] , our patients were predominantly males.…”

Section: Discussionsupporting

confidence: 88%

Clinical Outcome of Exocrine Pancreatic Adenocarcinoma: A Single Center Experience

Gohar

Megahid

Rizk

et al. 2017

Kasr-Al-Aini J.of Clin. Onc. and Nuc. Med.

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Background: Pancreatic carcinoma is an uncommon tumor with a high mortality rate. Because of the late presentation of the disease, only a small percent of patients are candidate for surgery. Aim: To assess the epidemiology and the clinical outcome of patients diagnosed with pancreatic adenocarcinoma presented to the Clinical Oncology Department at Menoufia University. Methods: All patients presenting with exocrine pancreatic carcinoma from January 2007 to December 2011 were included. Epidemiological features of patients and their treatment details and outcome were collected retrospectively from the medical records. An equal number of matched controls were interviewed and filled a questionnaire to identify possible risk factors. Results: Exocrine pancreatic adenocarcinoma represented 1.4 % of all cancer patients treated at our institution. The study included 76 patients and 76 controls. Pancreatic cancer patients were significantly more likely to be overweight when compared to controls (OR= 2.51, 95%CI: 1.04-6.06). Diabetes mellitus and smoking were significantly more prevalent among patients (OR= 2.36, 95%CI: 1.23-4.54; OR= 2, 95%CI: 1.05-3.81; respectively). The median time to progression was 12 weeks (95%CI: 9.46-14.53) and the median overall survival was 16 weeks (95%CI: 12.22-19.78). Patients with earlier tumor stage and those who underwent surgery followed by adjuvant chemotherapy had significantly better overall survival (p=0.02 and <0.001, respectively). Conclusion: Exocrine pancreatic adenocarcinoma is an uncommon tumor among cancer patients treated at the Clinical Oncology Department of Menoufia University. Diabetes mellitus, higher body mass index and smoking are significantly more prevalent in pancreatic carcinoma patients. Earlier tumor stage and undergoing surgery followed by chemotherapy are associated with statistically significant better overall survival.

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Section: Discussionsupporting

confidence: 88%

Clinical Outcome of Exocrine Pancreatic Adenocarcinoma: A Single Center Experience

Gohar

Megahid

Rizk

et al. 2017

Kasr-Al-Aini J.of Clin. Onc. and Nuc. Med.

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“…[33][34][35][36] The results showed that the proportion of PDAC patients with diabetes mellitus was 23.9%, which is comparable to that reported by several authors. 1,22,28 Similar to the findings of other studies, the presenting symptoms for PDAC were dominated in our series by weight loss (68.6%), abdominal pain (64.2%) and jaundice (53.7%). 27,36,37 Present study showed that the tumor was located to the pancreatic head in the majority of cases (71.6%), This was in accordance with the results reported in the literature.…”

Section: Discussionsupporting

confidence: 90%

“…27,36,37 Present study showed that the tumor was located to the pancreatic head in the majority of cases (71.6%), This was in accordance with the results reported in the literature. 22,25,28 As for many other cancers in Morocco, we noted that the majority of our patients presented with locally advanced or metastatic disease. This confirms the late presentation of PDAC and agrees with the finding of other studies.…”

Section: Discussionmentioning

confidence: 50%

“…The mean age of our patients was 61.24 years, which is similar to that observed in other studies. [22][23][24][25][26][27][28] However, other literature data reported higher average age (67-77 years). [29][30][31][32] In accordance with the results of other studies, the patients were predominantly males.…”

Section: Discussionmentioning

confidence: 99%

“…This confirms the late presentation of PDAC and agrees with the finding of other studies. [27][28][29] Treatment modalities of PDAC include surgery, chemotherapy, radiation therapy, and palliative care. Treatment options are selected depending on the disease's stage and the patient's condition in a multidisciplinary approach.…”

Section: Discussionmentioning

confidence: 99%

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Pancreatic ductal adenocarcinoma in a Moroccan population: analysis of six years experience

et al. 2018

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Background: Few studies have been done to investigate pancreatic cancer in Morocco. Therefore, the aim of our study was to describe the epidemiological, clinical and therapeutic features of pancreatic ductal adenocarcinoma in Moroccan population.Methods: Author retrospectively reviewed the medical data of pancreatic ductal adenocarcinoma patients presented to the Medical Oncology Department of the Military Hospital Moulay Ismail in Meknes, Morocco, from January 2011 to December 2016.Results: The study included 67 cases of pancreatic ductal adenocarcinoma. The mean age of patients was 61.24±10.35 years. Male/female ratio was 3.2/1. 20.9% of patients were cigarette smokers, 10.5% alcoholics. 23.9% diabetics, 3.0% with a positive family history of pancreatic cancer and 25.4% with a family history of diabetes mellitus. The main symptoms for consultation were weight loss (68.6%), abdominal pain (64.2%), jaundice (53.7%) and vomiting (25.4%). The tumour was located to the pancreatic head in 71.6% of cases. Stage IV disease was the most common stage representing 47.8% of patients. Biliary and duodenal stent placements were respectively performed in 10.4% and 3.0% of patients. 23.9% of patients underwent curative surgery, 7.5% had palliative surgery and 86.6% received chemotherapy. The median overall survival for the entire cohort was 9.3 months (95% CI 7.2-12.1 months) with a median follow-up of 9.7 months (2-63 months).Conclusions: The data on pancreatic ductal adenocarcinoma in Moroccan population are similar to the epidemiologic literature data. With multimodality treatments, the results in terms of survival benefit seem to be similar to those in Asian and Caucasian populations.

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Pancreatic Cancer Stem Cells

Ravindran

Khoshchehreh

Aicher

et al. 2015

Cancer Stem Cells: Emerging Concepts and Future Perspectives in Translational Oncology

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Epidemiology and Risk Factors for Exocrine Pancreatic Cancer in a Northern African Population

Abstract: According to our results, cholecystectomy could possibly be a risk factor for pancreatic cancer in Algerian population.

Cited by 11 publications

References 20 publications

Clinical Outcome of Exocrine Pancreatic Adenocarcinoma: A Single Center Experience

Clinical Outcome of Exocrine Pancreatic Adenocarcinoma: A Single Center Experience

Pancreatic ductal adenocarcinoma in a Moroccan population: analysis of six years experience

Pancreatic Cancer Stem Cells

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