Dysentery is frequently associated with high morbidity and mortality and is found in young children and mainly affects those in developing nations. Rural people across the world trust on herbal remedies and homeopathic medicines for their primary health care on account of their easy accessibility, efficacy and exceptionally cost ampleness in relation to modern drugs. The purpose of the present study was to compile knowledge of traditional healers and indigenous people in Chittagong hill tracts, Bangladesh, including Rangamati, Bandarban and Khagrachari for the treatment of dysentery. The ethnomedicinal data was gathered from January 2019 to January 2020 through open and focused group discussions and individual meetings utilizing semi-structured questionnaire. An aggregate of 75 people were interviewed, including traditional health practitioners. Frequency and percentage were utilized to sum up the data. Relative frequency of citation (RFC) was determined and inclination positioning activities were led to appraise the significance of the revealed medicinal plants. An aggregate of 90 medicinal plants from 52 families and 79 genera were recorded during the survey. Leaves were discovered to be the most largely used plant part (35%) followed by root (19%) and herbs (40%) were the essential wellspring of medicinal plants, followed by trees (20%). The major mode of preparation is juice (68%) followed by paste (11%) and cooked form (7%). Centella asiatica scored the highest RFC value (0.773). The survey addresses the preliminary information of certain medicinal plants having anti-dysenteric property. However, further phytochemical investigation, validation and clinical trial sought to be conducted, with need given to those that scored the most elevated RFC values prior to utilizing these plants as an option in contrast to modern medicine.
Dhaka Univ. J. Pharm. Sci. 21(2): 127-146, 2022 (December)
In this present world COVID-19 pandemic is one of the biggest concern. An appealing medication focus among Covids is the fundamental protease; SARS-CoV-2 protease Mpro (6Y2F) due to its fundamental role in handling the polyproteins that are interpreted from the viral RNA. The present study showed the interaction of favipiravir, ganciclovir, raltegravir and remdesivir against 6Y2F, using molecular docking were analyzed. Among those ligands’ interaction with protein structure, 6Y2F on raltegravir (-7.4 kcal/mol) and remdesivir (-6.9 kcal/mol), respectively displayed maximum binding affinity. The interactions of four ligands were contrasted with each other in that ganciclovir and raltegravir form highest number of hydrogen bond with 6Y2F. The interacting amino acids residues (Gly143, Ser144, Cys145) were studied and all selected ligands were predicted to be non-carcinogens and non-AMES toxic.
Dhaka Univ. J. Pharm. Sci. 20(2): 177-183, 2021 (December)
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.