Aim: The objective of the present study was to investigate the phytochemical analysis, cytotoxic and antioxidant activities of the bark extracts of Erythrina variegate. Place and Duration of Study: The plant, E. variegate was collected from Botanical Garden, Mirpur, Dhaka and also from Curzon Hall, University of Dhaka, Bangladesh in June 2014 and then the sample was identified by the National Herbarium of Bangladesh, Mirpur, Dhaka (DACB; Accession Number-36148). Methodology: Preliminary phytochemical screening was done for determining the nature of phytoconstituents. Brine shrimp lethality bioassay technique was done to study the cytotoxic Shahriar et al.; EJMP, 11(3):1-5, 2016; Article no.EJMP.18866 2 properties. Aluminum chloride colorimetric method was applied for the determination of flavonoids and the total antioxidant ability was assessed by the phospho-molybdenum method. Results: Primary phytochemical analysis confirmed the presence of alkaloid, carbohydrate, glycosides and flavonoids. The extracts showed some toxicity to A. salina with LC 50 values ranging from 1.41 to 3.66 µg/ml which was compared with standard vincristine sulphate (VS, LC 50 value 0.92 µg/ml). n-Hexane extract of E. variegate was found to contain highest amount of flavonoids (3.77±1.97 mg/gm; quercetin equivalent) and ethanol extract of E. variegate was found to have highest antioxidant acitivity (2.03±0.09 mg/gm ascorbic acid equivalent). Conclusion: It can be concluded that the plant extracts of E. variegate possess several antioxidant activities which justifies its use as folk medicine. Short Research Article
In this present world COVID-19 pandemic is one of the biggest concern. An appealing medication focus among Covids is the fundamental protease; SARS-CoV-2 protease Mpro (6Y2F) due to its fundamental role in handling the polyproteins that are interpreted from the viral RNA. The present study showed the interaction of favipiravir, ganciclovir, raltegravir and remdesivir against 6Y2F, using molecular docking were analyzed. Among those ligands’ interaction with protein structure, 6Y2F on raltegravir (-7.4 kcal/mol) and remdesivir (-6.9 kcal/mol), respectively displayed maximum binding affinity. The interactions of four ligands were contrasted with each other in that ganciclovir and raltegravir form highest number of hydrogen bond with 6Y2F. The interacting amino acids residues (Gly143, Ser144, Cys145) were studied and all selected ligands were predicted to be non-carcinogens and non-AMES toxic. Dhaka Univ. J. Pharm. Sci. 20(2): 177-183, 2021 (December)
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