Background and Objectives: Inflammation in the intestine causes diarrhea due to an increased release of pro-inflammatory cytokines such as TNF-α, IL-1, and IL-6. These are triggered by the exposure of E. coli-LPS to epithelial cells of the intestinal mucosa as well as low concentration of zinc in plasma such as in infants or children who are experiencing diarrhea. This paper aims to determine the effects of zinc supplementation on pro-inflammatory cytokines (TNF-α, IL-1 and IL-6) in mice with E. coli-LPS-induced diarrhea. Materials and Methods: This study used a controlled trial experimental design in the laboratory. A sample size of 20 mice were randomly divided into 4 groups: 1) Control group was given standard foods, 2) Trial group was given E. coli-LPS 2.5 mg/kg/oral once on day1, 3) Prevention group was given E. coli-LPS + 30 mg/kg/oral of zinc once daily for 12 days, 4) Therapeutic group was given E. coli-LPS, and were then given 30 mg/kg/oral of zinc once daily for 12 days if diarrhea occurred. Blood samples of mice were taken through the orbital sinus on the 0, 5th, 10th hour, and on the 4th, 8th and 12th days. Results: Positive effects of zinc supplementation on levels of pro-inflammatory cytokines were observed, in which the higher levels of zinc were present, the lower levels of pro-inflammatory cytokines, especially TNF-α were observed. However, there was an increase of IL-1 and IL-6 levels on the 8th day in the prevention and therapeutic groups. Conclusion: Oral zinc supplementation had a significant positive effect on the levels of pro-inflammatory cytokines. Where there were higher levels of zinc, lower levels of pro-inflammatory cytokines TNF-α were present.
Background: Hospital malnutrition is reported to be prevalent in Indonesia. Wether nutritional status at admission is associated with nutritional status at discharge and length of stay remains unclear.Objective: To assess the association between nutritional status at the admission and nutritional status at discharge and length of stay in adult hospitalized patients.Methods: A total subjects of 293 adult patients who were admitted to internal and neurology departments of Dr. Sardjito, Dr.M.Jamil, and Sanglah hospitals were included in this study. Nutritional status of each patient was assessed using Body Mass Index (BMI) measured at admission and on discharge. Information on length of stay and hospital charge was collected based on medical records.Results: Low energy intake was associated with worse outcome (OR 1,2 95%CI 1,74-11,94). Non infection diseases were also found to be associated with worse outcome (OR 6,91 95%CI 4,03-11,85) and length of stay (OR 1,83 95%CI 1,10-3,05). Prehospitalized and class of hospitalized were associated with length of stay (OR 2,34 95%CI 1,36-8,57).Conclusion: Low nutritional status on admission and low energy intake were associated with higher risk of worse outcome (OR 2,34 95%CI 1,05-5,24) and (OR 3,41 95%CI 1,36-8,57).
<p>ABSTRACT</p><p>Background: Chronic energy deficiency (CED) is a chronic malnutrition in calorie and protein that become a nutritional problem in pregnant women. Prevalence of CED in Indonesia in 2013 is 23.4% and Sedayu Subdistrict is 11.4%. Impact of CED in pregnant women is the risk of low birth weight and its relationship with increase chronic desease in the future. Dietary pattern and food taboo are factor risks of nutritional problem of pregnant women.</p><p>Objectives: To analyze association between dietary pattern and food taboo with chronic energy deficiencies in pregnant women in Sedayu Subdistrict, Bantul,Yogyakarta.</p><p>Methods: This was an observational study with cross sectional design with approachment in quantitative and qualitative. Qualitative method used focus group disscussion (FGD) with 14 CED and non CED in pregnant women. Samples were 201 pregnant women in Sedayu Subdisctrict that were collected by total sampling methods. This research was held in April until June 2014. Data were analyzed using univariate analysis (descriptive), bivariate (chi-square and Mann Whitney), and multivariate (multiple logistic regression). Intake of energy and carbohydrate was analyzed by using Nutrisurvey software.</p><p>Results: Chi-square showed that there was no significant association between dietary pattern and food taboo with CED in pregnant women (p>0.05). A number of 17.91% pregnant women had the risk of CED, 20.99 % had less of source prime energy, and 20.22% had food taboo. Food taboo is food that rich in protein, vitamin and mineral (fruit and vegetable) and energy.</p><p>Conclusions: There was no significant association between dietary pattern and food taboo with CED in pregnant women.</p><p>KEYWORDS: dietary pattern, food taboos, pregnant women, chronic energy deficiencies</p><p>ABSTRAK</p><p>Latar belakang: Kekurangan energi kronis (KEK) merupakan keadaan kekurangan zat gizi terutama energi dan protein yang masih menjadi masalah gizi pada ibu hamil. Prevalensi KEK di Indonesia tahun 2013 sebesar 23,4 % dan Kecamatan Sedayu sebesar 11,4% masih merupakan masalah kesehatan. Ibu<br />hamil yang KEK berisiko melahirkan bayi dengan berat badan rendah dan meningkatkan risiko penyakit kronis di masa depan. Pola makan dan pantangan makan merupakan salah satu faktor risiko dari masalah gizi ibu hamil.</p><p>Tujuan: Mengetahui hubungan antara pola makan dan pantangan makan dengan kejadian KEK pada ibu hamil di Kecamatan Sedayu, Bantul, Yogyakarta.</p><p>Metode: Jenis penelitian ini adalah observasional analitik dengan rancangan cross sectional dengan pendekatan kuantitatif dan kualitatif. Sampel pada penelitian ini adalah seluruh ibu hamil yang berada di Kecamatan Sedayu Kabupaten Bantul. Metode kualitatif dengan menggunakan focus group disscussion (FGD) kepada kelompok ibu hamil yang KEK dan tidak KEK yang berjumlah 14 orang. Penelitian kuantitatif menggunakan metode pengambilan sampel total sampling, yang berjumlah 201 orang ibu hamil. Penelitian dilaksanakan pada bulan April hingga Juni 2014. Data dianalisis dengan menggunakan analisis univariat (deskriptif), bivariat (chi-square dan Mann Whitney) dan multivariat (regresi logistik). Data asupan energi dan protein dianalisis dengan menggunakan software Nutrisurvey.</p><p>Hasil: Hasil uji chi-square menunjukkan tidak ada hubungan antara pola makan dan pantangan makan dengan kejadian KEK pada ibu hamil (p>0,05). Sebanyak 17,91% ibu hamil berisiko KEK, 20,99% diantaranya mempunyai pola makan pokok (nasi) yang kurang dan 20,22% masih mempunyai pantangan makan. Makanan yang dipantang yaitu makanan sumber protein, sumber vitamin dan mineral (buah dan sayur), dan bahan makanan sumber energi.</p><p>Kesimpulan: Pola makan dan pantangan makan pada ibu hamil tidak berhubungan dengan kejadian KEK.</p><p>KATA KUNCI: pola makan, pantangan makan, ibu hamil, KEK</p>
Backgound: Indonesia as a tropical country with high humidity, has good environment for worm breeding particularly Soil Transmitted Helminths (STH). The prevalence of worm infestation in Indonesia is still relatively high, about 60% of 220 million Indonesian population, 21% of them are elementary school-age children. STH intensity greatly affects the nutritional status of patients, in wich more severe infection leads to poorer nutrition condition.Objective: To identify severity of STH infection in elementary school student at the working area of Kokap I Health Center of Kulonprogo and its correlation with nutritional status and anemia.Method: The study was undertaken in 25 elementary schools at the working area of Kokap I Health Center of Kulonprogo. Samples were all students of grade I as many as 241 students. Worm examination was done by using Kato-Katz method, assessment of nutrition status was based on body weight according to height (weight/height), anemia status was assessed from Hb level using Cyanmethaemoglobin method.Results: The results of the study showed that most of students (83,6%) were well nourished and were non anemic (84,9%). No student belonged to severe anemic category, 3 students (1,3%) had anemia at medium category and 31 students (13,8%) were slightly anemic. Out of 51 students that positively got STH infection, 16 students (31.4%) had light infection of A. lumbricoides, 36 students (70,6%) had T. trichiura and 4 students (5,9%) had hookworm. A. lumbricoides infected 7 student (13,7%) and T. trichiura infected 8 student (15,7%) both at medium criteria. There was no infection at severe criteria. The result of Somers’ D analysis showed that there was no significant correlation between the two variables (p>0,05).Conclusion: There was no correlation between severity of STH infections with nutrition status and anemia in elementary school student.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.