The effect of zinc supplementation on pro-inflammatory cytokines (TNF-α, IL-1 AND IL-6)  in mice with Escherichia coli LPS-induced  diarrhea

Yusuf, Sulaiman; Soenarto, Yati; Juffrie, Muhammad; Lestariana, Wiryatun

doi:10.18502/ijm.v11i5.1960

Cited by 7 publications

(11 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Innate immune cells usually use pattern recognition receptors (PRRs) to recognize pathogen-associated molecular patterns (PAMP) ( Almeida et al, 2020 ). After the virus enters the infected cells through interaction with the receptor, it can further promote the innate immune cells to secrete cytokines and chemokines, such as IL-1β, IL-6, TNF-α, and IFN-β, which lead to the activation of inflammasomes ( Yusuf et al, 2019 ). The phagocytes can phagocytize and degrade the viral particles.…”

Section: Discussionmentioning

confidence: 99%

“Fei Yan No. 1” as a Combined Treatment for COVID-19: An Efficacy and Potential Mechanistic Study

Zhong-zhu

Zhou

et al. 2020

Front. Pharmacol.

View full text Add to dashboard Cite

There has been a large global outbreak of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), representing a major public health issue. In China, combination therapy, including traditional Chinese medicine (TCM) as a treatment for COVID-19 has been used widely. “Fei Yan No. 1” (QFDYG) is a formula recommended by the Hubei Government to treat COVID-19. A retrospective study of 84 COVID-19 patients from Hubei Provincial Hospital of TCM and Renmin Hospital of Hanchuan was conducted to explore the clinical efficacy of QFDYG combination therapy. TCMSP and YaTCM databases were used to determine the components of all Chinese herbs in QFDYG. Oral bioavailability (OB) ≥ 30% and drug-like (DL) quality ≥ 0.18 were selected as criteria for screening the active compounds identified within the TCMSP database. The targets of active components in QFDYG were determined using the Swiss TargetPrediction (SIB) and Targetnet databases. The STRING database and the Network Analyzer plugin in Cytoscape were used to obtain protein-protein interaction (PPI) network topology parameters and to identify hub targets. Gene Ontology (GO) enrichment was conducted using FunRich version 3.1.3, and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment using ClueGO version 2.5.6 software. PPI and compound-pathway (C-T) networks were constructed using Cytoscape 3.6.0. Compared with the control group, combined treatment with QFDYG resulted in a significantly higher rate of patients recovering from symptoms and shorter the time. After 14 days of treatment, QFDYG combined treatment increased the proportion of patients testing negative for SARS-CoV-2 nucleic acid by RT-PCR. Compared with the control group, promoting focal absorption and inflammation as viewed on CT images. GO and KEGG pathway enrichment indicated that QFDYG principally regulated biological processes, such as inflammation, an immune response, and apoptosis. The present study revealed that QFDYG combination therapy offered particular therapeutic advantages, indicating that the theoretical basis for the treatment of COVID-19 by QFDYG may play an antiviral and immune response regulation through multiple components, targets, and pathways, providing reference for the clinical treatment of COVID-19.

show abstract

Section: Discussionmentioning

confidence: 99%

“Fei Yan No. 1” as a Combined Treatment for COVID-19: An Efficacy and Potential Mechanistic Study

Zhong-zhu

Zhou

et al. 2020

Front. Pharmacol.

View full text Add to dashboard Cite

show abstract

“…Evidence from in vitro studies sμggests that SARS-CoV-2 replication can be inhibited by increase in zinc concentration [ 81 ]. Zinc supplementation studies have shown decreased oxidative stress due to its participation in free radical scavenging and pro-inflammatory markers levels such as IL-1, IL-6 and TNFα, even during infection [ 82 , 83 ]. Zinc may therefore reduce the inflammation in the gut caused by SARS-CoV-2.…”

Section: Discussionmentioning

confidence: 99%

A Pilot Study to Examine If Dietary Habits Can Affect Symptomology in Mild Pre-Vaccination COVID-19 Cases

McDaid

Chopra

2022

Biology

View full text Add to dashboard Cite

The heterogeneity of the severity of symptoms of COVID-19 experienced by the young and healthy individuals is poorly understood. The present study was undertaken to mainly examine whether the respective diets and the type of symptoms experienced by patients are predictive of having long COVID-19. Disease severity was assessed with a symptomatology questionnaire and used to group 55 participants in asymptomatic (AS), mild symptoms (S) and long COVID (LC). We found that experiencing a higher number of symptoms as well as fatigue were predictors of developing LC whereas those who experienced rhinorrhea were less likely to develop LC. Blood samples were also taken to measure vitamin D [25 (OH)D] concentrations and duration of spike IgG antibodies. In this study, serum 25 (OH)D was not significantly different between 3 symptom groups with median (IQR) ng/mL levels of 22.0 (12.3) in the AS, 22.3 (7.5) in S, and 24.9 (9.4) in the LC group (p ≥ 0.05). The duration of IgG antibody response was found to vary greatly, with some individuals showing raised IgG over a year after infection. To examine whether dietary factors can influence the severity of symptoms, diet was analysed using 4–7-day food diaries as well as a Food Frequency Questionnaire (FFQ). Some nutrients such as vitamin E, polyunsaturated fatty acids, fibre, and iron were associated with lower severity of COVID-19. Lower intake of vitamin E was associated with having LC with a median (IQR) intake of 6.2 mg (3.8) seen in LC vs. 8.6 mg (7.2) in the AS group (p = 0.047). This pilot study has highlighted a few differences in the number and type of symptoms experienced by the young non-hospitalised individuals with mild and long COVID-19 and identified a few dietary components for their potential protective role against long COVID-19, however, the findings need to be confirmed with further large scale studies.

show abstract

“…Thus, the effective action of Zn along with Pc lowered the amount of the cytokine like TNF-α as reported earlier. 57 In the case of histopathological images, the administration of ZnPcN and formulation of ZnPcPNs might ameliorate damaged hepatic lobules with recovered cytoplasm and reduced residual inflammation considering the central vein and moderately dilated sinusoids. The administration of ZnPcN and formulation of ZnPcPNs reduced the ROS damage and oxidative stress that prevented further histological and renal damage.…”

Section: Semmentioning

confidence: 99%

Zinc–Phthalocyanine Loaded PLGA–PVA–Chitosan Nanosystem for the Enhancement of Antidiabetic Activity

Govardhane,

Shende

2023

Mol. Pharmaceutics

View full text Add to dashboard Cite

Zinc, one of the most common nutraceutical agents, proved to be effective for diabetes as it regulates the blood glucose level by inhibiting glucagon secretion. However, the hepatotoxicity of zinc creates necrosis, hepatic glycogen depletion, and apoptosis of hepatocytes at the concentration of 10 μg/kg. Phthalocyanine, a bluecolored compound, is an aromatic macrocyclic compound with good antioxidant ability owing to its heterocyclic nitrogen conjugation. The conjugation of zinc with phthalocyanine aimed to reduce the toxicity associated with zinc and enhance the antidiabetic activity at a lower dose. Hence, the present research work possessed the insights of the synthetic aspect of zinc with phthalocyanine along with its entrapment in the poly(lactic-co-glycolic acid) (PLGA)−chitosan nanosystem via oral administration in the treatment of diabetes. A nanoprecipitation technique was implemented for the synthesis of PLGA chitosan nanoparticles, and formulation was further optimized using a central composite design. Twenty trials provided by the software selected optimum concentrations of PLGA, poly(vinyl alcohol) (PVA), and chitosan in consideration with particle size up to 335.6 nm, zeta potential 27.87 mV, and entrapment efficiency of 75.67 ± 8.13%. Addition of chitosan to the nanocarrier system for controlling the release of the drug for 3 days was accompanied by the improvement in the glucose level within 28 days. The delivery of the nanoparticles showed enhancement in the cholesterol, triglyceride, alkaline phosphatase (ALP), urine parameters, and proinflammatory cytokines. The application of DoE (design of experiments) for the optimization of the nanoparticles established a controlled release formulation for diabetes, which displayed safety and effectiveness in streptozotocin (STZ)-induced diabetic rats.

show abstract

The effect of zinc supplementation on pro-inflammatory cytokines (TNF-α, IL-1 AND IL-6) in mice with Escherichia coli LPS-induced diarrhea

Cited by 7 publications

References 15 publications

“Fei Yan No. 1” as a Combined Treatment for COVID-19: An Efficacy and Potential Mechanistic Study

“Fei Yan No. 1” as a Combined Treatment for COVID-19: An Efficacy and Potential Mechanistic Study

A Pilot Study to Examine If Dietary Habits Can Affect Symptomology in Mild Pre-Vaccination COVID-19 Cases

Zinc–Phthalocyanine Loaded PLGA–PVA–Chitosan Nanosystem for the Enhancement of Antidiabetic Activity

Contact Info

Product

Resources

About