Demam atau pireksia merupakan gejala dari suatu penyakit. Penyakit infeksi seperti demam berdarah, tifus, malaria, peradangan hati, dan penyakit infeksi lain merupakan contoh penyakit yang sering mempunyai gejala demam. Untuk mengurangi dampak negatif ini maka demam perlu diobati dengan antipiretik. Obat yang biasa digunakan adalah parasetamol dan asetosal. Beberapa penelitian tentang parasetamol akhir-akhir ini menemukan bahwa meskipun cukup aman tetapi parasetamol memiliki banyak efek samping. Pemanfaatan tumbuhan sebagai obat tradisional masih selalu digunakan karena efek samping yang ditimbulkan obat tradisional relatif kecil, sehingga aman digunakan. Salah satu contohnya adalah biji mahoni (Swietenia Mahagoni (L.). Jenis penelitian ini adalah penelitian eksperimental laboratorium seca in vivo untuk mengetahui efektifitas antipiretik ekstrak biji mahoni (Swietenia Mahagoni (L.) terhadap tikus wistar. Analisis statistik menggunakan uji ANOVA dengan nilai p= 0,001
Objective: To evaluate the potency of the fraction of marine sponge Stylissa carteri in inducing cell death, inhibiting spheroid growth, and its impact on pro-apoptotic protein Mcl-1S in breast cancer cells. Methods: Stylissa carteri were collected from Pramuka Island followed by ethanol extraction and ethyl acetate fractionation. To evaluate the cytotoxic effect of fraction, the HCC-1954, MDA MB 231, and MCF-7 cells were treated with the fraction of Stylissa carteri and MTT assay was then performed. The effect on spheroid growth was evaluated in HCC-1954 cells. The combined effect of the ethyl acetate fraction and paclitaxel were analyzed using combination index (CI) and immunoblotting on the pro-apoptotic protein Mcl-1S. Furthermore, compounds in this fraction were identified using GC-MS. Results: Data showed that both the MDA MB 231 and HCC-1954 cells were interestingly more sensitive to the fraction as compared with MCF-7 cells. The IC 50 of the ethyl acetate fraction on HCC-1954, MDA MB 231 and MCF-7 were 4.1 µg/ml, 3.9 µg/ml, and 123.8 µg/ml, respectively. In addition, the fraction triggered spheroid destruction within 10 days. The CI of paclitaxel and ethyl acetate fraction of Stylissa carteri were less than 0.52. Moreover, this combination induced upregulation of the Mcl-1S protein. Furthermore, some fatty acid-based structures were predicted as the major compounds in this fraction. Conclusion: The ethyl acetate fraction of Stylissa carteri induces cell death and spheroid destruction in aggressive breast cancer cells. It has a synergistic cytotoxic effect with paclitaxel on MDA MB 231 cell death and upregulates Mcl-1S protein.
This research was intended to see how the Kirkpatrick four level evaluation model is applied in the Library Material Processing training program organized by the Education and Training center of National Library of Indonesia. This evaluation research uses the Kirkpatrick evaluation model (Reaction, Learning, Behavior, Result). The subject of this research is training organizers, training instructors and training participants in the processing of library materials. Data collection techniques in this study used observation, documentation and interviews. Data validity test is done using triangulation of sources and methods. The results of this study show that the implementation of the Library Material Processing Training program has not gone well based on the aspect that being evaluated. 1) In the Reaction evaluation aspect, the implementation of training at this stage goes well. It can be seen from the results of the evaluator's last evaluation score which has a score of 93.88 or very satisfied and the last evaluation score of the instructor who has a score of 90.66 or very satisfied. 2) In the aspect of learning evaluation, the training process goes well according to the plan that was made before. This can be seen from the final score of all participants who have a score above the least limit. 3) in the Behavior aspect, the training organizers have not carried out observations of the participants' behavior after the training. 4) Then in the Result aspect, the training organizers also have not carried out observations on the participants' contributions or the use of participant's knowledge of the library performance. Keywords: Program Evaluation, Library Material Processing Training, Kirkpatrick Evaluation Model
Tujuan dari penelitian ini adalah untuk mempelajari bagaimana cashless society, disiplin diri, dan literasi keuangan mempengaruhi kebiasaan belanja mahasiswa akuntansi Universitas Trisakti. Metode pengumpulan data termasuk penyebaran kuesioner dengan ukuran sampel 160 peserta. Pengujian Teori, meliputi Uji Koefisien Determinasi, Uji F Statistik, dan Uji T Statistik, mengikuti teknik analisis data Uji Validitas dan Reliabilitas, Uji Autokorelasi, Uji Multikolinearitas, dan Uji Heteroskedastisitas. Penelitian ini menunjukkan bahwa mahasiswa akuntansi di Universitas Trisakti sangat dipengaruhi oleh literasi keuangan, pengendalian diri, dan budaya cashless. Selain itu, pengaruh literasi keuangan, pengendalian diri, dan masyarakat tanpa uang tunai terhadap kebiasaan belanja mahasiswa akuntansi di Universitas Trisakti semuanya diperiksa secara bersamaan.
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