UJI EFEKTIFITAS EKSTRAK BIJI MAHONI (Swietenia Mahagoni (L.) Jacq)  SEBAGAI ANTIPIRETIK PADA TIKUS WISTAR (Rattus norvegicus)

Fadhil, Muhammad; Desnita, Eka; Elianora, Dewi

doi:10.33854/jbdjbd.106

Cited by 3 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Beberapa insektisida alami mengunakan berbagai tanaman yang mengandung zat toksik bagi larva nyamuk. 8 Salah satu tanaman yang mengandung insektisida nabati dan berpotensi sebagai larvasida adalah mahoni (Swietenia mahagoni). Biji mahoni mengandung insektisida berupa senyawa alkaloid, flavonoid, dan saponin 9 serta limonoid.…”

Section: Pendahuluanunclassified

Pengaruh Pemberian Ekstrak Biji Mahoni (Swietenia mahagoni) Terhadap Kematian Larva Culex sp

Hidayati

Suprihatini

2020

aspirator

View full text Add to dashboard Cite

Abstract. Mahogany seed extract (Swietenia mahagoni) is a natural larvacidal material which contains limonoid, flavonoid, saponins and alkoloid. Mahogany seed extract can kill Culex sp larvae, which known as filariasis vectors. There are several mosquitoes control are used to pressing Culex sp larvae growth, such as using larvacidal and fogging but have bad impact on the circumtances The study observed effect of mahogany seed extract on Culex sp. larvae mortality. This study utilized an experimental method with ANOVA and probit analysis to determined LC50 and LT50. Extraction method were used in this study was maceration method. This research used some variation of mahogany seed extract concentration, consist of 8%, 10%, 20%, 50%, with negative control (-) used distilled water. Research repetition was carried out 3 times with a total sample of 325 larvae. Observations were made at 15, 60, 120, 240, 420 and 720 minutes (12 hours). This study found that there was a significant effect between the concentration of mahogany seed extract on larval mortality with Fcount > Ftable (0.05 ≥ 0.01). The concentration that effectively kills 50% of Culex sp (LC50) larvae was 10%. the time which was needed to kill 50% of Culex sp (LT50) larvae was 204,230 minutes. The higher the concentration level of mahogany seed extract were used, so that more larval mortality rates. The morphology or larvae body structure after administration of mahogany seed extract was damaging in the abdomen and thorax, allegedly inhibited growth hormone due to the mechanism of action of mahogany seed extract as an antifeedant This reaserch can be using mahogany seed extract with different methods and larvae. Mahogany seed extracts are expected to be applied in society as a vector control and this research can be developed using mahogany seed extract with different methods and larvae. Keywords: Mahogany seeds, Extract, Culex sp, larvacidal, Maceration, Abstrak. Ekstrak biji mahoni (Swietenia mahagoni) merupakan bahan larvasida alami yang mengandung limonoid, flavonoid, saponin dan alkoloid. Ekstrak biji mahoni diduga bisa membunuh larva Culex sp, yang berperan sebagai vektor filariasis. Ada beberapa cara penanggulangan nyamuk yang digunakan untuk menekan pertumbuhan larva Culex sp, seperti penggunaan larvasida dan fogging tetapi memiliki dampak yang buruk untuk lingkungan. Tujuan dari penelitian ini untuk melihat pengaruh ekstrak biji mahoni terhadap kematian larva Culex sp. Penelitian ini menggunakan metode eksperimental dengan analisis ANOVA dan analisis probit untuk menentukan LC50 dan LT50 . Metode ekstraksi yang digunakan dalam penelitian ini adalah modifikasi maserasi. Konsentrasi ekstrak biji mahoni yang diujikan yaitu 8%, 10%, 20%, 50%, dengan kontrol (-) menggunakan aquadest. Pengulangan dilakukan sebanyak 3 kali dengan total sampel 325 larva. Pengamatan dilakukan pada menit ke 15, 60, 120, 240, 420 dan 720 menit (12 jam). Penelitian ini memperoleh hasil bahwa adanya pengaruh yang signifikan antara konsentrasi ekstrak biji mahoni terhadap kematian larva dengan Fhitung > Ftabel (0,05 ≥ 0.01). Konsentrasi yang efektif membunuh 50% larva Culex sp (LC50) adalah 10%. waktu yang dibutuhkan untuk membunuh 50% larva Culex sp(LT50 ) adalah 204,230 menit. Semakin tinggi tingkat konsentrasi ekstrak biji mahoni semakin tinggi pula tingkat kematian larva. Morfologi atau struktur tubuh larva setelah pemberian ekstrak biji mahoni mengalami kerusakan di bagian abdomen dan toraks, diduga mengalami penghambatan hormonpertumbuhan karena mekanisme kerja ekstrak biji mahoni sebagai antifeedant. Ekstrak biji mahoni diharapkan dapat diaplikasikan di dalam masyarakat sebagai pengendalian vector dan Penelitian ini bisa dikembangkan dengan menggunakan ekstrak biji mahoni dengan metode dan larva yang berbeda. Kata Kunci: Biji mahoni, Ekstrak, Culex sp, Larvasida, Maserasi

show abstract

Section: Pendahuluanunclassified

Pengaruh Pemberian Ekstrak Biji Mahoni (Swietenia mahagoni) Terhadap Kematian Larva Culex sp

Hidayati

Suprihatini

2020

aspirator

View full text Add to dashboard Cite

show abstract

“…Utilization of plants as traditional medicine is still always used by people in Indonesia because there are several benefits that can be obtained, including low prices, related to the ease of obtaining raw materials, even medicinal plants can be grown alone, the side effects caused by traditional medicines are relatively small so they are safe to be used [3].…”

Section: Introductionmentioning

confidence: 99%

A Review: Testing Antioxidant Activity on Kawista Plants (Limonia acidissima L.) in Indonesia

Syakri

Syahrana

Ismail

et al. 2021

Open Access Maced J Med Sci

View full text Add to dashboard Cite

BACKGROUND: Antioxidants are natural ingredients that can block the oxidation process of free radicals that enter the body so that damage to body cells can be prevented. Kawista plants are one of the plants that have antioxidant activity. AIM: This article review aims to determine the compounds that have antioxidant activity found in Kawista plants, the method used in testing antioxidants on Kawista plants, and the IC50 value found in antioxidant testing on Kawista plants. METHODS: The method used in this study is the Population, Intervention, Control, and Outcome method through inclusion and exclusion criteria using the keywords “Antioxidant activity of Limonia acidissima,” “Antioxidant activity of Feronia limonia,” “Antioxidant activity of Kawista,” “Testing Antioxidants in L. acidissima,” and “L. acidissima” with databases used for literature searches. RESULTS: This review shows that Kawista plants have antioxidant activity of various compounds based on the test method used. CONCLUSION: Compounds in Kawista plants that have antioxidant activity are phenols, especially phenolic acids, flavonoids, flavonols, triterpenoids, saponins, tannins, terpenes, steroids, alkaloids, and glycosides. Kawista plant activity tested had IC50 with an average value of very strong (16.45 g/mL), strong (77.85 g/mL), moderate (135.02 g/mL), weak (196.67 g/mL), and very weak (751.89 g/mL).

show abstract

In Vivo and In Vitro Antidiabetic Assay of Purified Mahoni Seeds Extract (Swietenia mahagoni (L.) Jacq)

Ahamd,

Malik,

Handayani

2023

Biomed. Pharmacol. J.

View full text Add to dashboard Cite

This study examined the future of Mahoni seed as an aspirant drug for treating diabetes. Mahogany seeds were washed using n-hexane solvent and followed by ethanol solvent. Extracts were measured using a standard spectrophotometric plate reader with acarbose (Glucobayâ). Glucose tolerance was tested in alloxan-challenged mice. The results indicated that the extract had potency against a-glucosidases inhibited through a non-competitive mechanism. The IC50 value of the extract is 4.7 μg/ml, which was lower than 5.7 μg/ml for acarbose and has less activity on glucose tolerance at doses of 120 and 240 mg/kg. As a conclution, purified mahogany seed extract got the ability to be developed as a new antidiabetic drug candidate.

show abstract

UJI EFEKTIFITAS EKSTRAK BIJI MAHONI (Swietenia Mahagoni (L.) Jacq) SEBAGAI ANTIPIRETIK PADA TIKUS WISTAR (Rattus norvegicus)

Cited by 3 publications

References 0 publications

Pengaruh Pemberian Ekstrak Biji Mahoni (Swietenia mahagoni) Terhadap Kematian Larva Culex sp

Pengaruh Pemberian Ekstrak Biji Mahoni (Swietenia mahagoni) Terhadap Kematian Larva Culex sp

A Review: Testing Antioxidant Activity on Kawista Plants (Limonia acidissima L.) in Indonesia

In Vivo and In Vitro Antidiabetic Assay of Purified Mahoni Seeds Extract (Swietenia mahagoni (L.) Jacq)

Contact Info

Product

Resources

About