Objective To create a model for prediction of success of uterine‐preserving procedures in women with placenta accreta spectrum (PAS). Methods PAS‐ID is a multicenter study that included 11 centers from 9 countries. Women with PAS, who were managed between January 1, 2010 and December 31, 2019, were retrospectively included. Data were split into model development and validation cohorts, and a prediction model was created using logistic regression. Main outcome was success of uterine preservation. Results Out of 797 women with PAS, 587 were eligible. Uterus‐preserving procedures were successful in 469 patients (79.9%). Number of previous cesarean sections (CS) was inversely associated with management success (adjusted odds ratio [aOR] 0.02, 95% confidence interval [CI] 0.001–3.63 with five previous CS). Other variables were complete placental invasion (aOR 0.14, 95% CI 0.05–0.43), type of CS incision (aOR 0.04, 95% CI 0.01–0.25 for classical incision), compression sutures (aOR 2.48, 95% CI 1.00–6.16), accreta type (aOR 3.76, 95% CI 1.13–12.53), incising away from placenta (aOR 5.09, 95% CI 1.52–16.97), and uterine resection (aOR 102.57, 95% CI 3.97–2652.74). Conclusion The present study provides a prediction model for success of uterine preservation, which may assist preoperative and intraoperative decisions, and promote incorporation of uterine preservation procedures in comprehensive PAS protocols.

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Objective To determine if treatment with pravastatin prevents preeclampsia in pregnant patients at risk for preeclampsia. Material & Methods The study was performed in four major tertiary hospitals in Surabaya, Bandung, and Makassar between 2017-2021. Pregnant women at high risk of developing preeclampsia were recruited and randomized into an intervention group and control group. The control group received low dose aspirin (80 mg) and calcium (1 g) daily, while the intervention group received additional pravastatin (20 mg twice daily) started from 14-20 weeks’ gestation until delivery. The pregnancy was followed until delivery, and the clinical data was collected. The primary outcome was the occurrence of preeclampsia. Result A total of 173 people participated in this study, including 86 in the control group and 87 in the pravastatin group. The pravastatin group had a significantly lower rate of preterm preeclampsia (13.8% vs 26.7%; p=0.034; (OR=0.034, 95% CI: 0.202-0.905) and preterm birth (16.1 % vs. 36 %; p=0.003; OR= 0.340, 95% CI: 0.165-0.7), mostly indicated preterm birth. Preeclampsia occurs later in the pravastatin group than in the control group (36.39+2.32 vs 34.89+3.38 weeks, p=0.048). Overall the pravastatin group had better perinatal outcomes. Neonates with low Apgar scores (<7) at 1 minute (5.7% vs 25.6%, p=0.000) and 5 minutes (2.3% vs 25.6%, p=0.028) were significantly less common in the pravastatin group. Additionally, the rate of low birthweight babies (< 2500g) was lower in pravastatin group (27.6% vs 40.7%; p= 0.069). Conclusion Pravastatin (20 mg bid) significantly reduces the risk for preterm preeclampsia and preterm birth in women at a high risk of developing preeclampsia.

Abstrak Tujuan : Penelitian ini akan dilakukan untuk identifikasi prevalensi dan faktor risiko ibu terhadap angka kejadian IUGR di Rumah Sakit Umum Penidikan (RSUP) Dr. Hasan Sadikin Bandung. Metode : Penelitian ini menggunakan desain deskriptif retrospektif menggunakan data sekunder dengan melihat data rekam medik rawat inap pasien hamil dengan IUGR yang lahir di RSUP Dr. Hasan Sadikin Bandung periode bulan Januari 2018 – Desember 2019 berdasarkan kriteria inklusi dan eksklusi. Hasil : Prevalensi kasus IUGR di RSUP Hasan Sadikin Bandung adalah 76,16 orang per 1000 kehamilan. Karakteristik pasien dengan diagnosis IUGR terbanyak pada usia 21-34 tahun (64,32%), dengan paritas paling banyak pada primipara dengan total 147 kasus (79,45%). Faktor Risiko IUGR terdiri dari nilai BMI terbanyak dengan 86 subjek (46.5%) memiliki nilai BMI di atas batas normal. Tiga puluh lima subjek penelitian (18.9%) memiliki riwayat merokok, sementara 15 pasien (8.1%) memiliki riwayat mengonsumsi alkohol. Penyulit dalam kehamilan dengan PEB sebagai penyakit penyulit terbanyak. 28 pasien (15,1%). Pasien memiliki riwayat penyakit kronis 25 orang (13,5%) di antaranya mempunyai riwayat hipertensi kronis. Mayoritas dari seluruh pasien bersekolah hingga jenjang sekolah menengah. Kesimpulan : Prevalensi kasus IUGR di RSUP Hasan Sadikin Bandung adalah 76,16 orang per 1000 kehamilan. Karakteristik pasien terbanyak pada usia 21-34 tahun (64,32%), dengan paritas paling banyak pada primipara dengan total 147 kasus (79,45%). Kata kunci : Prevalensi, Intrauterine Growth Restriction, Faktor Risiko

Objective: According to the 2016 Routine Health Profile Report, the exact causes of maternal mortality are hypertension (33.07%) and bleeding (27%). The exact cause of preeclampsia is unknown and is therefore referred to as the “disease of theory”. This study aimed to determine the relationship between age, BMI, gravida and parity with preeclampsia. Methods: This cross-sectional, analytic observational study, conducted in Hasan Sadikin Hospital, Bandung. Subjects are pregnant women undergoing antenatal care at Hasan Sadikin Hospital Bandung, in May 2020 a total of 40 women with a gestational age of ≥ 20 weeks. The univariate and bivariate data were analyzed with SPSS. The Saphiro Wilk test was used to measure the data normality. The ANOVA one-way test and Fisher test were used to analyze the bivariate data. Results: Results show that of 19 samples with preeclampsia, 13 people (68.4%) were older than 35 years old with p-value of 0.042 which indicates a significant relationship. There is no significant difference between BMI, gravida, and parity, with the incidence of preeclampsia with p-value 0.602, 0.664, and 0.661 respectively. Conclusion: There is a relationship between mother’s age and the incidence of preeclampsia in Dr. Hasan Sadikin Hospital with p value = 0.042. This means older than 35 years old mothers have a tendency to develop preeclampsia.

Tujuan: Untuk mengetahui gambaran karakteristik klinis dan histopatologi kanker ovarium anak di RSUP Dr. Hasan Sadikin Bandung. Metode: Penelitian ini menggunakan desain penelitian deskriptif. Data dikumpulkan dari rekam medis pasien kanker ovarium anak di RSUP Dr. Hasan Sadikin Bandung tahun 2017–2020. Hasil: Terdapat 22 pasien kanker ovarium anak yang sesuai dengan kriteria inklusi dan eksklusi. Ditemukan pasien kanker ovarium anak paling banyak usia 13–18 tahun sebanyak 13 orang (59,1%), stadium klinis I sebanyak 10 orang (45,4%), histopatologi jenis sel germinal sebanyak 17 orang (77%), dan gejala klinis benjolan pada perut sebanyak 16 orang (33%). Kesimpulan: Kanker ovarium anak di RSUP Dr. Hasan Sadikin Bandung Bandung periode 1 Januari 2017 – 31 Desember 2020 paling sering terjadi pada pasien dengan rentang usia 13–18 tahun, terdiagnosis pada stadium I, karakteristik histopatologi tipe sel germinal, dan memiliki gejala klinis berupa benjolan pada perut. Overview of Clinical Characteristics and Histopathology of Pediatric Ovarian Cancer at RSUP Dr. Hasan Sadikin Bandung Abstract Objective: To determine pediatric ovarian cancer’s clinical characteristics and histopathology at RSUP Dr. Hasan Sadikin Bandung. Methods: This study used a descriptive research design. Data were collected from medical records of pediatric ovarian cancer patients at RSUP Dr. Hasan Sadikin Bandung in 2017 – 2020. Result: 22 pediatric ovarian cancer patients met the inclusion and exclusion criteria. The majority of pediatric ovarian cancer patients were in the age 13-18 years as many as 13 people (59.1%), clinical stage I characteristics as many as 10 people (45.4%), histopathological of germ cell types as many as 17 people (77%), and clinical symptoms as lumps in the abdomen as many as 16 people (33%). Conclusion: Pediatric ovarian cancer at RSUP Dr. Hasan Sadikin Bandung period 1 January 2017 – 31 December 2020 most often occurred in patients aged 13–18 years, diagnosed at stage I, histopathological characteristics of germ cell type, and had clinical symptoms in the form of abdominal lump. Key words: Ovary, Pediatric Ovarian Cancer, Clinical Characteristic, Histopathological Characteristic

Objective: To discover the factors affecting the occurrence of maternal deaths. The high maternal mortality rate (MMR) in Indonesia is still a common problem which needs urgent solution.Methods: This is an analytic observational, cross-sectional study using a case control approach Fifty two cases were selected as cases, another 52 were selected as control. The sampling was performed by simple random sampling. The instruments used in this study were the medical records of mothers who gave birth in Dr. Hasan Sadikin General Hospital Bandung from 1 January 2009-31 December 2013. Data analysis was performed using chi-square test. Results:In this study, the results showed that the risk factors contributing to maternal deaths were pregnancy complication (p<0.001), delivery complication (p<0.001), puerpural complication (p=0.022), age (p=0.030), parity (p=0.427), prior medical history (p<0.001), antenatal care (p=0.007), maternal education (p=0.527), and area of residence (p=0.049). Conclusions:The risk factors that contribute to maternal deaths include pregnancy complication, delivery complication, puerpural complication, maternal age, prior medical history, antenatal care, and area of residence.