Diabetes has been found to be associated with low levels of thiamine stores in the body, as thiamine directly affects carbohydrate metabolism. Amplified renal clearance of thiamine has been found in both type I and type II diabetic patients. It has been shown that high-dose thiamine therapy may have a therapeutic effect on early-stage diabetic nephropathy. The aim of this study was to evaluate various biochemical parameters and serum thiamine levels in type I and type II diabetic patients and compare them with a healthy control group.
The present study evaluated the blood glucose, superoxide dismutase (SOD) and glutathione peroxidase (GPX) in Cinnamon cassia bark extract (CCBE) treated alloxan-induced diabetic albino rats. Study Design: Experimental study. Setting: Animal house of Al-Tibri Medical College, Karachi was selected for conducting the present study. Period: January 2014 to December 2014. Methodology: A sample of twenty rats was randomly divided into 4 groups. Rats were grouped as A1 (n=5)-Negative control, A2 (n=5)-Positive controls (alloxan treated rats), and experimental groups B1 (n=5) and B2 (n=5) included diabetic rats which received 0.3 grams and 0.6 grams of CCBE respectively. Intraperitoneal alloxan (120 mg /kg in 0.5 ml dissolved in acetate buffer) was used for induction of diabetes. C. cassia bark extract was prepared under standard protocol. Blood glucose (glucose oxidase method), SOD and GPX (Elisa kit) were detected from blood samples after 30 days. Data was analyzed on SPSS. Data was analyzed by one-way ANOVA and post-Hoc was used for group comparisons. Data was analyzed at 95% CI (p< 0.05). Result: Blood glucose, SOD and GPX showed statistically significant differences (p<0.036). CCBE treated rats showed low glucose levels and elevated SOD and GPX enzyme activity (p<0.05).
Background: Wound treatment still a task for medical professionals, according to the time advancement. We need to elaborate further new interventions to cope up this common factor of community. The objective of the study was to assess the anti-inflammatory topical role of Lactobacillus acidophilus with antibiotic in wound repair of rats based on of microscopic parameters. This comparative study was conducted in the Department of Anatomy Al-Tibri Medical Collage and Hospital Isra University Karachi Campus from December 2018 to April 2019.Methods: Total 18 male of wistar rats were randomly selected for this study. The study comprised of three topical groups Control, Antibiotic and Lactobacillus acidophilus groups respectively.Results: The samples were taken from the wound site for the preparation of microscopic slides, to count the numbers of neutrophils, lymphocytes and macrophages for the evaluation of anti-inflammatory process in both groups on day 3 and 7. Data obtained were analyzed by SPSS version 20 by applying One Way ANOVA and post hoc Tukey’s test.Conclusions: The results were shown potent anti-inflammatory effects of Lactobacillus acidophilus group in comparison with other conventional therapy. The study concludes that the topical application of Lactobacillus acidophilus had remarkable anti-inflammatory effects in wound management.
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