Introduction: Lead is a highly toxic non-essential metal. Children have a wide spectrum of subclinical and clinical effects due to lead exposure and lead poisoning. Objectives: To identify the extent of the problem of lead toxicity among children and its association with anthropometry, nutritional status and awareness about lead toxicity. Materials and Methods: Study population comprised children admitted in CSI Hospital as inpatients. Purposive sampling was done to enroll patients with no risk of lead exposure. A sample sizeof 100 was calculated using prevalence formula. Anthropometric and blood examinations were done along with knowledge, attitude and practices questionnaire to assess knowledge of caregivers about lead toxicity. Results: A total of 100 children were screened. The mean (standard deviation) blood lead level (BLL) was 7.1 (3.6). 18% of the children demonstrated BLLs of >10 ?g/dl. 19.3% of boys as compared to 15.8% girls had BLL >10 ?g/dl. 36.4% of children belonging to the lower socio-economic status had BLL >10 ?g/dl. The developmental quotient was inversely proportional to the measured BLL. Mean weight, height, and blood indices were lower in thechildren with BLL >10 ?g/dl. The knowledge regarding the adverse health effects of lead toxicity was very poor. Conclusion: Once the early toxic effects are detected before the onset of irreversible changes, the potential victims can be saved. So screening of children for lead toxicity should be made mandatory whenever doubt arises, and since knowledge regarding lead toxicity is poor among caregivers, awareness should be created through health education to the community.

This review covers the explanation of all the biological efficiencies of the N-Heterocyclic Carbenes (NHCs). Most of the reviews of NHCs focused on its chemical and physical applications, we have noted the properties, types and applications of metal complexes of NHCS. Our principle aim is to throw a light on the biological applications of the complexes. N heterocyclic carbenes (NHC) have been discovered in the 90's and have been marking an important place in organic chemistry. NHCs contain divalent carbon atoms. It is bound to at least one nitrogen atom. Presence of heteroatoms imparts them a wide range of electronic behavior. They create stable bonds and compounds making them excellent ligands in coordination chemistry. Silver metal complexes of organic ligands had been an interesting research area for the pharmaceutical researchers. Because of the electron donating ability of NHCs, the formation of Ag metal complexes had been pursued by many inorganic chemists and they were evaluated for various biological activities. Thus, in this review we have listed out the Ag-NHCs which have anticancer potential and its use as cytotoxic therapeutic agents. This article concludes with the basic concept that, how to design efficient Ag-NHCs in order to develop efficient, biologically active metal complex derivatives.

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