Findings indicated that periodontal infection increases the risk of CHD and CVD. However, this meta-analysis provided no evidence for the existence of strong associations between periodontitis and CHD and CVD. Larger and better-controlled studies involving socially homogeneous populations and measuring specific periodontal pathogens are required to identify a definite association between periodontal disease and the risk of coronary heart disease and cerebrovascular disease.

While the prevalence of overweight was high among Jordanian children compared with that in the neighboring countries, the prevalence of obesity was lower.

The extent and severity of periodontal diseases appeared to be associated with increased odds of PLBW delivery. Nevertheless, more and larger intervention trials are needed before it can be fully accepted that periodontal infection is a true risk factor for PLBW.

Obstructive sleep apnea, snoring, and daytime sleepiness were common among Jordanian patients attending primary care clinics. More attention to OSA is needed in primary care, and patients at risk should be referred for further evaluation.

Thalassemia beta major is a hereditary hemolytic anemia disease with various grades of severity, which can be found with no or less globin chain qualitative synthesis. The patient often experiences hepatosplenomegaly, growth retardation and bone disorder and the thalassemia facies/chipmunk face appearance. The orofacial manifestations of beta thalassemia major are prominent cheek bones and protrusive premaxillae due to erythroid hyperplasia with depressed bridge of the nose. The dentition shows protrusion, flaring and spacing of the maxillary anterior teeth, open bite that leads to malocclusion. The anemic condition makes the patient is difficult to do all oral hygiene instruction thus caries index will increase. Dental practitioners especially pediatric dentists are required to have awareness towards the nature of the disease and its implication on dental care. Collaboration with hematologist has to be made in every dental treatment.