Dental diseases in subjects with β‐thalassemia major

Al‐Wahadni, Ahed; Taani, D. Quteish; Al‐Omari, Mousa

doi:10.1034/j.1600-0528.2002.00012.x

Cited by 38 publications

(43 citation statements)

References 12 publications

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“…Periodontitis represents a potential source of inflammation, and during the formation of peridontal pockets colonized with gramnegative anaerobic bacteria, an inflammatory cell infiltrate is recruited into the lesion that secretes proinflammatory mediators (41,46). Both gingivitis and periodontitis are seen more frequently in ESRD patients (47)(48)(49). Gingival hyperplasia is a relatively common periodontal complication in renal transplantation patients that has been attributed to cyclosporin dosage and the presence of dental plaques, likely contributing to gingival inflammation (50).…”

Section: Poor Oral Health As a Source Of Inflammationmentioning

confidence: 99%

Systemic Consequences of Poor Oral Health in Chronic Kidney Disease Patients

Akar

Carrero

et al. 2011

Clinical Journal of the American Society of Nephrology

165

136

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SummaryChanges in the oral cavity, such as periodontitis and other manifestations of poor oral health, are common in patients with chronic kidney disease (CKD) and may contribute to increased morbidity and mortality because of systemic consequences such as inflammation, infections, protein-energy wasting, and atherosclerotic complications. Poor oral health in CKD patients may thus represent an important, but often overlooked, problem. Several studies show that uremic patients have higher rates of decayed, missing, and filled teeth, loss of attachment, and periapical and mucosal lesions than the general population. The consequences of poor oral health may be more severe in CKD patients because of advanced age, common comorbidities such as diabetes, concurrent medications, and a state of immune dysfunction that may increase the risk for systemic consequences of periodontitis and other oral and dental pathologic conditions. Poor dentition and other signs of poor oral health should be an alarm clock also at early stages of CKD. However, it remains to be determined whether more successful management of poor oral health and periodontitis will reduce the risk of inflammation, infection, protein-energy wasting, and atherosclerotic complications in CKD patients. This review explores etiological factors and potential systemic consequences of poor oral health in CKD patients as well as possible preventive and therapeutic strategies.

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Section: Poor Oral Health As a Source Of Inflammationmentioning

confidence: 99%

Systemic Consequences of Poor Oral Health in Chronic Kidney Disease Patients

Akar

Carrero

et al. 2011

Clinical Journal of the American Society of Nephrology

165

136

View full text Add to dashboard Cite

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“…4 Previous studies have reported a higher frequency of periodontal diseases and dental caries in thalassemia patients. 5 A child's oral health can have a profound impact on eating, smiling, speaking and socializing. Oral conditions; such as dental caries may result in pain.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…1 It is a disease which not only affects patients but also leaves a devastating psychosocial effect on patients' family. 1 In Southeast Asia, α-thalassaemia, β-thalassaemia, hemoglobin E (Hb E) and Hemoglobin Constant Spring (Hb CS) are prevalent. The gene frequencies of α-thalassaemia reach 30-40% in Northern Thailand and Laos, 4.5% in Malaysia and 5% in the remote island of the Philippines whereas β-thalassaemia is vary between 1-9%.…”

Section: Introductionmentioning

confidence: 99%

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Oral Health Status and Impact on Oral Health-Related Quality of Life in Children with Thalassemia Major

et al. 2017

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Objective: The purpose of this study was to assess oral health status in children with thalassemia major, and the association of oral health status with oral-health related to quality of life. Methods: This cross-sectional study was comprised of 81 patients from various parts of lower northern Thailand. The study consisted of an interview and intraoral examination on thalassemia children at the hospital while they were undergoing routine blood transfusions. Data regarding OHI-S, DMFT/dmft and child-OIDP were determined for all the subjects. Results: The prevalence of oral impacts was high; 82.8% of all children reported at least one oral impact affecting their daily performance according to the Child-OIDP. The most prevalent impact was difficulty in eating. Conclusion:The risks of oral disease in thalassemia children remain high which affect their quality of life.

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“…Thalassemias are a diverse group of genetic blood diseases characterized by absence or decreased production of either α or β-globulin protein chains, resulting in microcytic anemia of varying degrees and referred to as α or β-thalassemia [1].…”

Section: Introductionmentioning

confidence: 99%

Antifungal Susceptibility of Oral Candida Species Isolated from Patients with Thalassemia Major

Kasem

Shokry

Mohamed

et al. 2017

JBMOA

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Background: Invasive fungal infections are the primary cause of morbidity and mortality in patients with thalassemias. This high mortality rate stems, in part, from the prevalence of resistance to antifungal agents. Candida species remain the most common cause of invasive fungal infection in patients with thalassemia. Nevertheless, other Candida species become increasingly spreading and need to be identified to a species level.Objectives: The objectives of the study were to estimate the prevalence of Candida infection among Thalassemia major patients compared to healthy controls and to identify the resistance patterns among the recovered species.Methods: A total of 60 oral samples were collected from two groups: Group I: 40 oral swabs were collected from patients clinically diagnosed with thalassemia major from the out-patient clinics of Pediatric department in Ain Shams University Hospital. Group II: 20 oral swabs were collected from healthy subjects matched in age and sex with the patients' group. The swabs were cultured onto both CHROM and Sabaroud's agar media. The recovered colonies on Sabaroud's agar were identified using Gram stain and Germ tube test while the colonies on CHROM agar were self-identified through color produced according to manufacturer instructions. For all identified colonies API 20 C AUX was used as a confirmatory test. Antifungal Susceptibility testing using Fluconazole (25μg).Voriconazole (1μg).Nystatin (100 units) was used to identify the resistance strains.Results: C. albicans, were isolated from 69.2% of cases while 30.8% were non C. albicans. (23% C. tropicalis and 7.8% C. krusei). Susceptibility testing for all identified colonies revealed that (13.8%) of all isolates were resistant to fluoconazole, (17.3%) to voriconazole and (89.7%) to nystatin. Conclusion:The use of CHROM agar media offers multiple advantages without increasing costs in comparison to other procedures. CHROM agar media have equal or greater sensitivity of detection, superior detection of mixed cultures as a result of better visualization of different species, and enable shorter times to report results. Antifungal susceptibility tests are now required to optimize antifungal treatment to avoid emergence of new resistant strains.

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Dental diseases in subjects with β‐thalassemia major

Cited by 38 publications

References 12 publications

Systemic Consequences of Poor Oral Health in Chronic Kidney Disease Patients

Systemic Consequences of Poor Oral Health in Chronic Kidney Disease Patients

Oral Health Status and Impact on Oral Health-Related Quality of Life in Children with Thalassemia Major

Antifungal Susceptibility of Oral Candida Species Isolated from Patients with Thalassemia Major

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