The aim of this study was to determine the tuberculin skin test (TST) response to three different BCG modalities [0.1 ml Tokyo (n=104), 0.05 ml Pasteur-Mérieux (n=137) and 0.1 ml Pasteur-Mérieux (n=100)] in a cohort of healthy newborns 5 months after vaccination at birth in Santiago, Chile. Among the 341 infants, 91.2% had a response to TST, and the mean+/-SD TST reaction size was significantly larger in infants receiving the Tokyo strain than in those receiving the 0.05 ml or 0.1 ml Pasteur-Mérieux strains (4.4+/-2.0, 3.5+/-1.3 and 3.1+/-1.4 mm, respectively; P<0.0001). The mean+/-SD of the BCG scar size was significantly lower in infants vaccinated with the Tokyo strain than in those vaccinated with the 0.1 ml Pasteur-Mérieux strain (3.9+/-1.2 vs. 4.3+/-1.1 mm; P=0.03) and no significant difference was found between infants receiving the Tokyo strain and the 0.05 ml Pasteur-Mérieux strain. However, the differences in TST size induced by diverse BCG vaccination modalities may not reflect the quality of the immunologically induced response in terms of TB protection.
Summary
Introduction: Parkinson disease (PD) is a degenerating disease with a deceitful character, impairing the central nervous system and causing biological, psychological and social changes. It shows motor signs and symptoms characterized by trembling, postural instability, rigidity and bradykinesia.
Objective: To evaluate the central hearing function in PD patients.
Method: A descriptive, prospect and transversal study, in which 10 individuals diagnosed of PD named study group (SG) and 10 normally hearing individuals named control group (CG) were evaluated, age average of 63.8 and (SD) 5.96. Both groups went through otorhinolaryngological and ordinary audiological evaluations, and dichotic test of alternate disyllables (SSW).
Results: In the quantitative analysis, CG showed 80% normality on competitive right-ear hearing (RC) and 60% on the competitive left-ear hearing (LC) in comparison with the SG that presented 70% on RC and 40% on LC. In the qualitative analysis, the biggest percentage of errors was evident in the SG in the order effect. The results showed a difficulty in identifying a sound when there is another competitive sound and in the memory ability.
Conclusion: A qualitative and quantitative difference was observed in the SSW test between the evaluated groups, although statistical data does not show significant differences. The importance to evaluate the central hearing process is emphasized when contributing to the procedures to be taken at the therapeutic follow-up.
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