To study the role of potential relationship of chronic human herpes virus types (3 – 6) infection and their correlation with the up-regulation of some cytokines (IL-2, IL-10 and IFN gamma) and effect of (8-OHdG) and (TAOC) levels onto male infertility. A Case – control study with semen samples which were collected by masturbation during the routine semen analysis of a total ninety age-matched participants as; fertile males 35 (38.9%) with proven fertility as a normal semen quality and infertile males 55 (61.1%) with at least one year of infertility and poor semen quality. All semen biomarkers of Human herpes viruses (HHVs): Varicella zoster virus (VZV-IgG), Epstein-Barr virus (EBV-IgG), Cytomegalovirus (CMV-IgG), Human herpes virus type 6 (HHV6-IgG), Interlukin-2 (IL-2), Interlukin-10 (IL-10), Interferon-gamma (IFN-γ), 8-hydroxy-2'-deoxy guanosine (8-OHdG) and Total Antioxidant Capacity (TAOC) which were included in the study had been estimated by quantitative ELISA based method and the correlations with sperms parameters were evaluated. The main significant outcomes in this study of the infertile males group 55 (61.1%) were: high percentages of seminal IgG; N (%; Mean±SD) were detected of HHV6, 48 (53.3%;1.26± 0.51) then CMV, 39 (43.3%;1.51± 0.95) followed by EBV, 34 (37.8%; 2.20±1.47), and the highest abnormal cytokines levels were estimated in; 44 (48.9%; 112.62±38.64) and 40 (44.4%; 22.75±10.65) for IFN-γ and IL-10 respectively. Furthermore, High 8-OHdG level was detected in 47 (52.2%;7.29±2.15) and very low level of TAOC was detected in 16 (17.8%;19.34±12.17). Significant negative correlation between semen biomarkers and standard sperms parameters was found which were represented by: 45 (50.0%) of total sperms count less than (33 million ml), 52 (57.8%) of progressive motile sperms less than (31%). Finally, about 33 (24.4%) of abnormal sperm morphology was detected. Our results hypothesized that chronic asymptomatic viral infection with increasing of cytokines concentrations consequently disturbance the semen oxidative status, antioxidant defense systems that induce sperms DNA damage then might be collectively act as a co-factors on the etiology of the male infertility.
This study was conducted in quail as a particular work for the of histopathological disorders between Sept6, 2018 Nov23, 2018 (77 days), to determine the effect of adding cinnamon alcohol extract to diets in ovulation and the fertility rate of the ovary and oviduct tissue in the quail, there are (3 treatments), and they were divided into 12 cages, each group consists of 10 males with 5 females. In the first group, quails were fed on a standard diet without any additives, while in the second treatment, 300 mg/kg of alcoholic extract of cinnamon was added to the quails’ diet, and the third treatment include the addition of 400mg.kg-1 of alcoholic cinnamon extract powder, the results of the histological study showed that the quail diet includes alcoholic cinnamon extract of additives (400 mg per kg) a physiological reproductive activity changes, ovulation and fertility rate were increased without any side effects. In conclusion, the results showed an increase in growth rate and cilia number and ciliated epithelial layer cells in their numbers and shapes in the oviduct, despite the rapid growth and rapid ovulation, unless there was no change in the shape of the egg or a change in its components.
Introduction: Rubella infection causes some health problems in pregnant women. Method: The current case-control study was suggested to detect the rubella infection level in women with recurrent abortion. The study was conducted on 65 patients who had suffered from abortion and 30 healthy women. Results: The results variables showed significant differences in birth numbers and in recurrent abortion percentages. All women in the current study suffered from abortion in the first trimester and about 60% of them suffered from abortion in the second trimester. Non-significant variations were seen in age in both groups and in age categories distribution. The rubella IgG levels according to study groups, occupation, smoking and age categories recorded non-significant differences between study groups (p=0.570). The rubella IgG levels showed non-significant differences (p=0.217) with abortion and birth numbers, significant differences in the number of births (p=0.000) and abortions in women with recurrent abortion (p=0.029). Rubella showed a weak positive correlation with the number of abortions in the first trimester and in the second trimester. Rubella IgG level didn’t affect all women in the current study who suffered from abortion in the first trimester and affected 60% of the women who suffered from abortion in the second trimester. This was non-significantly associated with the rubella IgG level (p=0.727). Conclusion: The present study concluded that rubella didn’t have any role in abortion and in recurrent abortion.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.