Aim: To evaluate a modified technique for scleral buckling surgery using chandelier endoillumination and minimal segmental buckling through a small conjunctival incision in rhegmatogenous retinal detachment repair.
Methods:A prospective interventional case study included 30 phakic eyes with primary rhegmatogenous retinal detachment (RRD) that was repaired by chandelier assisted scleral buckling (SB) using wide angle viewing (WAV) noncontact lens. A surgical procedure was performed to repair a break using transconjunctival sutures and a radial sponge was placed through a regional conjunctival opening. Anatomical and visual outcome at 6 months were the major outcome measures. Minor outcome measures included other postoperative complications.
Results:The mean ± standard deviation BCVA was improved from 0.33±0.61 preoperatively to 0.13±0.36 logMAR units 6 months postoperatively. External subretinal fluid drainage was performed in 18 cases (60%). Air injection was required in all patients (100%). Paracentesis was performed in 11 cases (37%). The primary anatomical success of retinal reattachment was achieved in all cases. Three patients (10%) experienced epi-retinal membrane (ERM) formation after 3 months. No other surgical complications were detected during follow up period.
Conclusion:In conclusion, scleral buckling using a cannula-based chandelier endo-illuminator is a modified new technique and is promising for the management of rhegmatogenous retinal detachment.
Purpose: to determine the correlation between the ABO blood groups and Rh factor with non-infectious uveitis.Methods: Cross-sectional study conducted on 175 Egyptian patients diagnosed with non-infectious uveitis. Venous blood sample (2ml) was taken from each patient to recognize the ABO and Rh blood group. Blood grouping results were collected and statistically analyzed.Results: Most of our uveitic patients were found to have blood group O (34.9%), while other ABO blood groups were represented as following: blood group A in 33.1%, blood group B in 22.3% and blood group AB in 9.7%. Rh factor was positive in 92.6% of the study participants. Most common etiologies of uveitis were Behçet's disease, idiopathic, Vogt-Koyanagi-Harada (VKH), juvenile idiopathic arthritis (JIA) and Ankylosing spondylitis (AS) in the following percentages: 28%, 21.1%, 21.1%, 13.7%, and 11.4%, respectively. Most Behçet's patients had blood type A+ or O+ (33/49, 67.3%), similar to those with idiopathic uveitis with higher preponderance of blood type A and O (26/37, 70.3%). Also, more than half of JIA cases have associated with blood type A+ and O+ (16/24, 66.7%). On the other hand, VKH patients had a higher prevalence of blood type O and B (27/37, 72.9%). AS cases had nearly equal distribution of different blood type A+, B+, AB+ and O+ (30%, 25%, 20% and 25%, respectively).
Conclusion:Blood group O and A were most commonly associated with non-infectious uveitis. In addition, positive Rhesus factor was strongly associated with such cases.
Background: Single nucleotide polymorphisms provide information on individuals’ potential reactions to environmental factors, infections, diseases, as well as various therapies. A study on SNPs that influence SARS-CoV-2 susceptibility and severity may provide a predictive tool for COVID-19 outcomes and improve the customized coronavirus treatment.Aim: To evaluate the role of human leukocyte antigens DP/DQ and IFNλ4 polymorphisms on COVID-19 outcomes among Egyptian patients.Participants and Methods: The study involved 80 patients with severe COVID-19, 80 patients with mild COVID-19, and 80 non-infected healthy volunteers. Genotyping and allelic discrimination of HLA-DPrs3077 (G/A), HLA-DQrs7453920 (A/G), and IFNλ4 rs73555604 (C/T) SNPs were performed using real-time PCR.Results: Ages were 47.9 ± 8, 44.1 ± 12.1, and 45.8 ± 10 years in severe, mild and non-infected persons. There was a statistically significant association between severe COVID-19 and male gender (p = 0.002). A statistically significant increase in the frequency of HLA-DPrs3077G, HLA-DQrs7453920A, and IFNλ4rs73555604C alleles among severe COVID-19 patients when compared with other groups (p < 0.001). Coexistence of these alleles in the same individual increases the susceptibility to severe COVID-19 by many folds (p < 0.001). Univariate and multivariate logistic regression analysis for the studied parameters showed that old age, male gender, non-vaccination, HLA-DQ rs7453920AG+AA, HLA-DPrs3077GA+GG, and IFNλ4rs73555604CT+CC genotypes are independent risk factors for severe COVID-19 among Egyptian patients.Conclusion: HLA-DQ rs7453920A, HLA-DPrs3077G, and IFNλ4rs73555604C alleles could be used as markers of COVID-19 severity.
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