Purpose: To evaluate the intermediate-term efficacy and safety of micropulsed diode laser cyclophotocoagulation in recurrent pediatric glaucoma. Patients and Methods: A prospective interventional study included children <16 years old diagnosed with recurrent glaucoma, attending Mansoura University, during the period from July 2017 to November 2017. Micropulsed diode laser sessions were performed in all the cases. The main outcome was the intraocular pressure reduction with monitoring of complications as secondary outcome. The mean follow-up period was 15.08 ± 1.1 (mean: 12–16) months. Results: A total of 36 eyes of 29 patients were included (62% males) with median age of 24 months. Primary congenital glaucoma represented 47.2% of the initial diagnoses. At the 15th month, the mean intraocular pressure dropped significantly from 37.5 ± 11.3 mmHg at baseline to 20.03 ± 2.7 mmHg (p < 0.001) with 37.15% reduction. The mean number of glaucoma medications decreased significantly from 2.6 ± 0.5 pretreatment to 1.7 ± 0.6 at the 15th month (p < 0.001). A total of 24 eyes (66.7%) required second session of treatment with mean number of 1.7 ± 0.5 sessions per eye. The cumulative probability of qualified success was 69.4%, 58.3%, 52.8%, 47.2%, and 41.7% at 1, 3, 6, 12, and 15 months after treatment. Qualified success was achieved in 61% at 15 months without statistically significant difference between the initial diagnoses (p = 0.61). None of the eyes developed any major ocular complications throughout the follow-up period. Conclusion: Micropulsed diode laser was proved to be a safe approach with relative effectiveness in controlling intraocular pressure in children with recurrent glaucoma.

PCG is the most prevalent type of childhood glaucoma, followed by acquired glaucoma especially traumatic hyphema. Combined trabeculotomy-trabeculectomy and Ahmed valve implantation are the most common surgical interventions. CGRN classification is found to provide a consensus skeleton and is recommended to be integrated in our routine ongoing clinical practice.

Increased levels of aqueous EPO and sCD44 may be associated with POAG. In addition, EPO and sCD44 may be useful proteins levels in aqueous of POAG patients as a result of glaucoma damage and not a cause. EPO and sCD44 concentrations in aqueous are a possible biomarkers for visual field loss in patients with POAG.

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Purpose: To evaluate the color Doppler imaging (CDI) and pattern visual evoked potential (P-VEP) examinations in primary open angle glaucoma (POAG) patients and investigate the relation between flow velocities measured by CDI and P-VEP examination in POAG patients. Methods: Sixty five POAG patients and 45 control subjects underwent CDI evaluation of the ophthalmic artery (OA), short posterior ciliary artery (SPCA) and central retinal arteries (CRA). The peak systolic velocities (PSV) and enddiastolic velocities (EDV) and resistive index (RI) of all retrobulbar vessels were measured. The latency and amplitude of P100 in P-VEP were recorded. The differences of CDI and P-VEP parameters among POAG and control groups were compared. The correlations between CDI parameters, visual field indices and P-VEP in POAG patients were evaluated by Pearson's correlation analysis. Results: POAG patients had the lower EDV and higher RI in the OA, CRA and SPCA comparing with that of control subjects. Also, POAG patients had lower PSV in OA and CRA comparing with that of control subjects. The latency of P100 in VEP delayed and the amplitude of P100 decreased in the POAG patients comparing with that of the control group. The RI of OA and SPCA were negatively correlated with the mean deviation (MD) values in the POAG patients. The RI of OA was positively correlated with the PSD value in POAG patients. The MD values in POAG patients were negatively correlated with the latency time of P100. The RI of OA was positively correlated with the latency time of P100 and negatively correlated with the amplitude of P100 in the POAG patients. Conclusions: The combination of the CDI and pattern VEP techniques provides further interpretation of ocular circulatory changes in POAG patients. Further studies are needed for assessment the relationship between circulatory and neural changes.