Erythropoietin and soluble CD44 levels in patients with primary open‐angle glaucoma

Mokbel, Tharwat H; Ghanem, Asaad A.; Kishk, Hanem; Arafa, Lamiaa F.; El-Baiomy, Azza A

doi:10.1111/j.1442-9071.2010.02318.x

Cited by 29 publications

(16 citation statements)

References 19 publications

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“…Similarly, increased levels of erythropoietin and soluble CD44 levels were found to be increased in aqueous humor of POAG patients as compared to healthy control, their circulating levels in serum were found to be insignificant. [27]…”

Section: Circulating Biomarkers In Glaucomamentioning

confidence: 99%

Circulating biomarkers in glaucoma, age-related macular degeneration, and diabetic retinopathy

Nath

Halder

Velpandian

2017

Indian J Ophthalmol

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Biomarkers to predict the altering physiological conditions over the period leading toward the ocular disorders are of major importance in therapeutics. Isolation and validation of the biomarkers specific to ocular diseases are a challenging task. Glaucoma is a neurodegenerative disease of the eye where the correlation of biomarkers in circulating fluid may be made specific for the eye. However, conditions such as wet age-related macular degeneration (AMD) and proliferative diabetic retinopathy (DR), circulating biomarkers might be having some degree of overlap with other conditions like cancer where a common factor such as angiogenesis is involved. Diabetes, a systemic disorder affecting the target organs such as eye, kidney, heart, and nervous system can be predicted using common circulating biomarkers. However, these markers need to be validated along with various stages of disease progression to enable the possibility of targeted pharmacological interventions apart from good glycemic control alone. This review compiles the attempts made to correlate such circulating biomarkers in the ocular conditions such as glaucoma, AMD, and DR in the search for a surrogate marker for diagnostic and prognostic value. To make biomarkers for the common convenience, genetic markers are excluded from this review.

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Section: Circulating Biomarkers In Glaucomamentioning

confidence: 99%

Circulating biomarkers in glaucoma, age-related macular degeneration, and diabetic retinopathy

Nath

Halder

Velpandian

2017

Indian J Ophthalmol

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“…Becerra and Amaral (93) hypothesized that identifi cation and separation of the structural determinants within the erythropoietin molecule could elucidate additional ways to minimize side effects associated with local administration of erythropoietin to the eye, an approach that offers advantages over systemic administration. Recently, the role of AH erythropoietin in POAG has been investigated, and the studies have concluded that erythropoietin is a possible biomarker for the disease (61,94,95) .…”

Section: Erythropoietinmentioning

confidence: 99%

Biomarkers in primary open angle glaucoma

Kokotas

Kroupis

Chiras

et al. 2012

Clinical Chemistry and Laboratory Medicine (CCLM)

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Glaucoma, a leading cause of blindness worldwide, is currently defi ned as a disturbance of the structural or functional integrity of the optic nerve that causes characteristic atrophic changes in the optic nerve, which may lead to specifi c visual fi eld defects over time. This disturbance usually can be arrested or diminished by adequate lowering of intraocular pressure (IOP). Glaucoma can be divided roughly into two main categories, ' open angle ' and ' closed angle ' glaucoma. Open angle, chronic glaucoma tends to progress at a slower rate and patients may not notice loss of vision until the disease has progressed signifi cantly. Primary open angle glaucoma (POAG) is described distinctly as a multifactorial optic neuropathy that is chronic and progressive with a characteristic acquired loss of optic nerve fi bers. Such loss develops in the presence of open anterior chamber angles, characteristic visual fi eld abnormalities, and IOP that is too high for the healthy eye. It manifests by cupping and atrophy of the optic disc, in the absence of other known causes of glaucomatous disease. Several biological markers have been implicated with the disease. The purpose of this study was to summarize the current knowledge regarding the non-genetic molecular markers which have been predicted to have an association with POAG but have not yet been validated.

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“…Other studies suggest that CD44 content in ocular tissue may represent a biomarker for glaucoma (Mokbel et al, 2010). CD44 is transmembrane protein, the principal receptor of the glycosaminoglycan, hyaluronan.…”

Section: Molecular Biomarkers In Glaucomamentioning

confidence: 98%