Blood grouping and Rh factor in Egyptian Patients with Non-infectious Uveitis

Abstract

Purpose: to determine the correlation between the ABO blood groups and Rh factor with non-infectious uveitis.Methods: Cross-sectional study conducted on 175 Egyptian patients diagnosed with non-infectious uveitis. Venous blood sample (2ml) was taken from each patient to recognize the ABO and Rh blood group. Blood grouping results were collected and statistically analyzed.Results: Most of our uveitic patients were found to have blood group O (34.9%), while other ABO blood groups were represented as following: blood group A in 33.1%, blood group B in 22.3% and blood group AB in 9.7%. Rh factor was positive in 92.6% of the study participants. Most common etiologies of uveitis were Behçet's disease, idiopathic, Vogt-Koyanagi-Harada (VKH), juvenile idiopathic arthritis (JIA) and Ankylosing spondylitis (AS) in the following percentages: 28%, 21.1%, 21.1%, 13.7%, and 11.4%, respectively. Most Behçet's patients had blood type A+ or O+ (33/49, 67.3%), similar to those with idiopathic uveitis with higher preponderance of blood type A and O (26/37, 70.3%). Also, more than half of JIA cases have associated with blood type A+ and O+ (16/24, 66.7%). On the other hand, VKH patients had a higher prevalence of blood type O and B (27/37, 72.9%). AS cases had nearly equal distribution of different blood type A+, B+, AB+ and O+ (30%, 25%, 20% and 25%, respectively). Conclusion:Blood group O and A were most commonly associated with non-infectious uveitis. In addition, positive Rhesus factor was strongly associated with such cases.

ABO blood grouping with negative or positive rhesus factors and relation to autoimmune diseases

“…A study done by Nik et al (2021) explained that the first report about blood grouping with rhesus factor and autoimmune diseases done by Cohen in 1963 the result showed no significant heterogeneity that some types of autoimmune diseases can be prevalent for some groups of blood like SLE prevalence with O blood grouping and AB blood grouping less effected with diseases and most risk factors is genetic and family history [5]. Also, Hashish et al (2022) agreed that some groups are more prone to get some diseases the O blood group can have peptic ulcers, and blood A groups can be prone to get stomach cancer and both groups can be associated with autoimmune diseases [6]. Questions about the effect or relation between blood grouping with positive or negative rhesus factors and autoimmune diseases increased.…”