Relevance of HLA-DP/DQ and INF-λ4 Polymorphisms to COVID-19 Outcomes

Ghazy, Amany A.; Alrasheedi, Abdullah N.; Elashri, Mohammed; Moussa, Hany H.; Rashwan, Eman K.; Amer, Ibrahim; Sharawy, Shimaa El; Elgamal, Shimaa; Tawfik, Salwa; Abdelnasser, Mohamed; Elsheredy, Amel

doi:10.3389/bjbs.2023.11044

Cited by 3 publications

(1 citation statement)

References 33 publications

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“…One of the most explored human genetic factors related to the SARS-CoV-2 infection is the human leukocyte antigen (HLA) genotype [7][8][9]. In humans, the HLA comprises a complex of genes on the 6th chromosome that coordinate and regulate the immune systems by encoding cell-surface proteins.…”

Section: Introductionmentioning

confidence: 99%

HLA-DQ2/8 and COVID-19 in Celiac Disease: Boon or Bane

Lerner,

Benzvi,

Vojdani

2023

Microorganisms

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The SARS-CoV-2 pandemic continues to pose a global threat. While its virulence has subsided, it has persisted due to the continual emergence of new mutations. Although many high-risk conditions related to COVID-19 have been identified, the understanding of protective factors remains limited. Intriguingly, epidemiological evidence suggests a low incidence of COVID-19-infected CD patients. The present study explores whether their genetic background, namely, the associated HLA-DQs, offers protection against severe COVID-19 outcomes. We hypothesize that the HLA-DQ2/8 alleles may shield CD patients from SARS-CoV-2 and its subsequent effects, possibly due to memory CD4 T cells primed by previous exposure to human-associated common cold coronaviruses (CCC) and higher affinity to those allele’s groove. In this context, we examined potential cross-reactivity between SARS-CoV-2 epitopes and human-associated CCC and assessed the binding affinity (BA) of these epitopes to HLA-DQ2/8. Using computational methods, we analyzed sequence similarity between SARS-CoV-2 and four distinct CCC. Of 924 unique immunodominant 15-mer epitopes with at least 67% identity, 37 exhibited significant BA to HLA-DQ2/8, suggesting a protective effect. We present various mechanisms that might explain the protective role of HLA-DQ2/8 in COVID-19-afflicted CD patients. If substantiated, these insights could enhance our understanding of the gene–environment enigma and viral–host relationship, guiding potential therapeutic innovations against the ongoing SARS-CoV-2 pandemic.

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Section: Introductionmentioning

confidence: 99%

HLA-DQ2/8 and COVID-19 in Celiac Disease: Boon or Bane

Lerner,

Benzvi,

Vojdani

2023

Microorganisms

View full text Add to dashboard Cite

show abstract

IFNL1 rs30461 polymorphism as a risk factor for COVID-19 severity: A cross-sectional study

Hammad,

Alseoudy,

Borg

et al. 2024

Cytokine

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HLA-DQ2/8 and COVID-19 in celiac disease: Boon or Bane

Lerner,

Benzvi,

Vojdani

2023

Preprint

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The SARS-CoV-2 pandemic continues to pose a global threat. While its virulence has subsided, it has persisted due to the continual emergence of new mutations. Although many high-risk conditions related to COVID-19 have been identified, the understanding of protective factors remains limited. Intriguingly, epidemiological evidence suggests a low incidence of the COVID-19-infected CD patients. The present study explores whether their genetic background, namely the associated HLA-DQs, offers protection against severe COVID-19 outcomes. We hypothesize that the HLA-DQ 2/8 alleles may shield CD patients from SARS-CoV-2 and its subsequent effects, possibly due to memory CD4 T cells primed by previous exposure to human-associated common cold coronaviruses (CCC) and higher affinity to those allele's groove. In this context, we examined potential cross-reactivity between SARS-CoV-2 epitopes and human-associated CCC and assessed the binding affinity (BA) of these epitopes to HLA-DQ 2/8. Using computational methods, we analyzed sequence similarity between SARS-CoV-2 and four distinct CCC. Of 924 unique immunodominant 15-mer epitopes with at least 67% identity, 37 exhibited significant BA to HLA-DQ 2/8, suggesting a protective effect. We present various mechanisms that might explain the protective role of HLA-DQ2/8 in COVID-19-afflicted CD patients. If substantiated, these insights could enhance our understanding of gene-environment enigma and viral-host relationship, guiding potential therapeutic innovations against the ongoing SARS-CoV-2 pandemic.

show abstract

Relevance of HLA-DP/DQ and INF-λ4 Polymorphisms to COVID-19 Outcomes

Cited by 3 publications

References 33 publications

HLA-DQ2/8 and COVID-19 in Celiac Disease: Boon or Bane

HLA-DQ2/8 and COVID-19 in Celiac Disease: Boon or Bane

IFNL1 rs30461 polymorphism as a risk factor for COVID-19 severity: A cross-sectional study

HLA-DQ2/8 and COVID-19 in celiac disease: Boon or Bane

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