Biocompatible pH and folate sensitive large pore MSNs with controllable and targeted CUR delivery.

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Multi‐component reaction indoline‐2,3‐dione derivatives, malononitrile, carbon disulfide and dimedone have led to newly synthesized 6′‐amino‐2′‐(4,4‐dimethyl‐2,6‐dioxocyclohexylidene)‐2‐oxospiro[indoline‐3,4′‐[1,3]dithiine]‐5′‐carbonitrile derivatives under acidic and base conditions with high efficiency during a simplified process. In acidic conditions, using MgO nanoparticleas as a catalyst, greater yields in shorter time was observed. The biological effects of synthetic derivatives such as antibacterial and antifungal effects based on inhibition zone diameter, minimum inhibitory concentration, minimum bactericidal concentration, minimum fungicidal concentration and antioxidant effects on DPPH free radical, have been the subject of previous studies. The results showed that some derivatives show higher antimicrobial effects compared to commercial drugs.

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l,3-Dithiin with two sulfurs in its structure is a six-membered, sulfur-containing heterocyclic compound. New derivatives of 6'-amino-2'-(arylidene)spiro[indeno[1,2-b]quinoxaline[1,3]dithiine]-5'-carbonitrile were prepared by the multi-component reaction of active methylene compounds, carbon disulfide, malononitrile and multi-ring compounds containing a carbonyl group in the presence of piperidine as a catalyst at room temperature with high efficiency. The antimicrobial effects including antibacterial and antifungal effects based on inhibition zone diameter (IZD), minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC) and minimum fungicidal concentration (MFC) were studied.

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