Pityriasis versicolor (PV) is a chronic superficial fungal infection. Management using azole drugs leads to drug resistance. The present study aimed to compare the clinical outcome of 0.1% adapalene gel vs 2% ketoconazole cream and their combination in PV. This randomized double‐blinded study was conducted on 90 PV patients divided into three equal groups. GI was treated with topical ketoconazole 2% cream twice daily and placebo, GII was treated with topical 0.1% adapalene gel twice daily and placebo and GIII was treated with topical combination of 0.1% adapalene gel (at night) and ketoconazole 2% cream (in the morning). All patients received medications for 4 weeks. Evaluation was done at 2 and 4 weeks and included clinical assessment, laboratory assessment, and patient satisfaction. We found that after 4 weeks of treatment, all groups showed significant improvement. There was better response in GIII in terms of lower rate of positive potassium hydroxide staining, higher rate of significantly improved cases and higher rate of well‐satisfied patients. However, the difference fell short of statistical significance. We concluded that a combination of adapalene gel and ketoconazole cream is very effective in treatment of PV with no or mild side effects.
A cross-sectional survey was conducted in Egypt from November 2015 to June 2016. Sexually active adult men were interviewed by a questionnaire designed by the authors. All the participants were evaluated by the abridged 5-item version of the International Index of Erectile Function (IIEF). A total of 3,000 sexually active Egyptian males participated in this study, 946 (31.53%) reported using PDE5Is at least once, and 2054 (68.47%) have never used them. The majority of those who used PDE5Is obtained them for recreational purposes mainly for pleasure (58.35%) and to increase duration/frequency of the intercourse (15.6%). Only 26.05% used PDE5Is to treat ED. The main source of obtaining PDE5Is was friends, relatives and colleagues (62.79%); 25.16% of users obtained the drug by themselves, and 6.66% were prescribed the drug by a pharmacist. Only 5.39% of users obtained the drug after a specialist physician consultation. Sildenafil was the most commonly used PDE5I (90.6%), and most of the users (88.05%) used them in an occasional manner even in the presence of erectile dysfunction, while 11.95% used the drug in a regular manner for every intercourse. PDE5Is are frequently used by the Egyptian male population, and most of them seemed to take them as recreational medications.
The present study dealt with evaluating the effect of whole body extracted by ethyle acetate of L. sericata, C. albiceps and M. domestica as exhibited antibacterial activity against some species of bacteria. They were shown to inhibit the growth of Gram-positive bacteria Staphylococcus aureus and Staphylococcus epidermidis, Gram-negative bacteria, Escherichia coli and Klebsiella pneumoniae and Fungi, Aspergillus fumigatus thus exhibited limited inhibitory effect towards Gram-positive bacteria Bacillus subtilis and Gram-negative Pseudomonas aeruginosa and Fungi Syncephalastrum racemosum and Candida albicans, this effect was slowed down when challenged with secretion on a solid media but no zone of complete inhibition was detected. Growth inhibiting activity was determined in liquid growth media using the Grampositive, Gram-negative bacterial and fungal strains as indicator organisms. The antiviral activity of whole body extracted by ethyle acetate of L. sericata, C. albiceps and M. domestica nES were tested against Vero cell line was developed for isolation and propagation of many enteroviruses and hepatitis A and average values were considered.
Background: the link between allergic rhinitis (AR) and asthma has been confirmed. AR is a risk factor for the onset of asthma. Spirometry is a noninvasive method to evaluate the lower respiratory system function in AR patients. The aim of the study: to evaluate spirometric lung functions and response to the post-bronchodilatation test in patients with allergic rhinitis.………………………………………...
Patients and Methods:This prospective cross-sectional study carried out on 100 patients with persistent AR. Spirometry, post-bronchodilatation test, serum total IgE and estimation of eosinophils in blood and sputum were performed for all patients.…………………………………… Results: Our results reconfirming the concept of "a single airway with a single disease". In our study, patients with persistent AR had impaired spirometric parameters. Conclusion: Our study confirming the predictive value of forced expiratory flow at 25% and 75% (FEF 25-75) as a marker of early bronchial involvement of small airway disease (SAD) in AR and also confirm the link between upper and lower respiratory system.
This study was conducted as an attempt to investigate the antimicrobial activity of Lucilia sericata (Diptera: Calliphoridae) maggots whole body extracts produced by different solvents against some bacterial and fungal strains, and also to study the role of L. sericata maggot extracts as antiviral therapeutic agents. Results showed that the highest antibacterial activity was attained by petroleum ether extract 24h post treatment for both Gram-positive and Gram-negative bacteria either by Microbial Growth Inhibition method or by Minimum Inhibitory Concentration method. Regarding the antifungal activity, all tested extracts showed antifungal activity against tested fungal strains and it may be arranged in descending order as the following: Petroleum Ether> Hexane > Ethyl Acetate > acetone. In addition, the antiviral activity was determined and the maximum non-toxic concentration was 39.06µg/ml. The obtained results explained that petroleum ether extract was effective as anti-HSV with anti-viral activity percent of 92.9. Generally, the available results indicate that L. sericata maggot extracts induced remarkable effects on both antimicrobial and antiviral activities.
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