We demonstrate a large-scale production of aligned SnO 2 nanofibers with a multi-nozzle electrospinning method combined with an air-shield enclosed rotating drum collector. The production rate by this multi-nozzle approach is several times higher than that of the single-nozzle electrospinning. The nanofibers produced were having a short range of diameters similar to the case of nanofibers produced by single nozzle electrospinning. The well-aligned nanofibers are subsequently processed into vertically oriented SnO 2 nanowires on an FTO substrate. The average diameter and length of the wires were 75 AE 25 nm and 19 AE 2 mm, respectively. Dye-sensitized solar cells using this nanostructured material as the working electrode yielded a short-circuit current density (J sc ) of 9.9 mA cm À2 (which is 42% higher than that achieved by nanowires produced by other methods), an open-circuit voltage (V oc ) of 0.525 V and a power conversion efficiency (h) of 2.53%. We believe that improvement of the multinozzle electrospinning is highly promising for commercialization due to simplicity and easiness of fabricating the spinneret, control over the diameter and spatial orientation of the fibers.

Extracellular vesicles (EVs) contain specific proteins, lipids, and nucleic acids that can be passed to other cells as signal molecules to alter their function. However, there are many problems and challenges in the conversion and clinical application of EVs. Storage and protection of EVs is one of the issues that need further research. To adapt to potential clinical applications, this type of problem must be solved. This review summarizes the storage practices of EVs in recent years, and explains the impact of temperature on the quality and stability of EVs during storage based on current research, and explains the potential mechanisms involved in this effect as much as possible.

The LMTB has designed and implemented a novel optical concept for the development of a versatile trepanning system, enabling the adjustment of the displacement and the inclination angle during circular rotation at up to 20000 r.p.m. The presented trepanning systems are able to laser machine through-holes diameters of 100 µm with a negative taper of up to 5°. Starting from an early stage of implementation, the novel trepanning system has been customized for different applications and industrial partners. The conference paper outlines the development steps and advanced performance, accenting laser micro machining results utilizing the novel LMTB trepanning system in operation at different laser parameters.

We present an alternative method of depositing a high-quality passivation film for heterojunction silicon wafer solar cells, in this paper. The deposition of hydrogenated intrinsic amorphous silicon suboxide is accomplished by decomposing hydrogen, silane, and carbon dioxide in an industrial remote inductively coupled plasma platform. Through the investigation on CO 2 partial pressure and process temperature, excellent surface passivation quality and optical properties are achieved. It is found that the hydrogen content in the film is much higher than what is commonly reported in intrinsic amorphous silicon due to oxygen incorporation. The observed slow depletion of hydrogen with increasing temperature greatly enhances its process window as well. The effective lifetime of symmetrically passivated samples under the optimal condition exceeds 4.7 ms on planar -type Czochralski silicon wafers with a resistivity of 1 Ωcm, which is equivalent to an effective surface recombination velocity of less than 1.7 cms −1 and an implied open-circuit voltage ( oc ) of 741 mV. A comparison with several high quality passivation schemes for solar cells reveals that the developed inductively coupled plasma deposited films show excellent passivation quality. The excellent optical property and resistance to degradation make it an excellent substitute for industrial heterojunction silicon solar cell production.

A moiré grating is a basic optical component used in various moiré methods for deformation measurement. In this study, nanoimprint lithography (NIL) was proposed to produce high frequency moiré gratings on metal samples. A new type of NIL mold and a hot embossing system were developed to overcome the poor flatness and roughness of metal samples. This three-layer mold based on nickel grating was unbreakable, and the self-developed hot embossing system used a bellows cylinder to satisfy the parallelism requirement of grating fabrication on metal samples. In order to generate high quality moiré patterns, the grating profile of the mold was optimized. Then, 1200-3000 lines/mm frequency gratings were successfully fabricated on the different materials such as SiO2, aluminum and stainless steel. In order to evaluate the quality of the replication, the distortion in the fabricated SiO2 grating was analyzed by an inverse moiré method. As an application, the replicated grating on the aluminum sample in combination with the moiré interferometry was used to measure the tensile deformation of the sample. The successful experimental results demonstrate the feasibility and reliability of nanoimprint lithography to produce gratings on metal samples.

Olfactory ensheathing cells (OECs) have shown promising results for patients with neurologic diseases in non-double-blind, placebo control studies. Thirty patients with a unilateral ischemic stroke of more than a year were enrolled in a phase 2, multicenter, randomized, double-blind, and placebo-controlled cell therapy trial with a subsequent 12-month follow-up. The primary therapeutic objective has shown that after 12 months, there were significant differences in National Institutes of Health Stroke Scale (NIHSS), modified Rankin Scale (mRS) and Barthel Index (BI) assessment scores among the OEC group, Schwann cell group and placebo medium group at one-year follow-up. The second therapeutic objective found that there were significant differences in NIHSS, mRS, and BI assessment scores when comparing the endpoint data with the baseline data in the OEC group. There was neither hypersensitivity reaction nor adverse event. The results of this multicenter, randomized, double-blind, and placebo-controlled study indicate that injecting OECs into the olfactory sub-mucosa have neurorestorative effects, which can improve the quality of life for patients with chronic ischemic strokes without serious side effects.

This paper reports a maskless multiple-beam laser lithography technique for large-area nanostructure/microstructure fabrication. This lithography technique can flexibly generate arbitrary nanostructures/microstructures over a large area at a high speed. The feature size of the nanostructures/microstructures can be controlled by exposure time and moving speed of the nanostage. Functional predesigned patterns, including split-ring resonator metamaterials for terahertz waves, can be obtained. More complicated structures can be made by single- and double-exposure schemes to make hybrid nanostructures/microstructures and tune surface plasmonic resonance properties. Meanwhile, microstructures with large height to lateral dimension ratios (2.5D microstructures) fabricated on silicon substrates can be used as mold tools for soft lithography. This technology shows its unique capacity to create various nanostructures/microstructures for extensive applications.

Several large outbreaks of hand-foot-mouth disease (HFMD) have occurred in the Asian-Pacific region since 1997, with Enterovirus 71 (EV71) and/or Coxsackievirus A16 (CAV16) as the main causative agents. Despite the close genetic relationship between the two viruses, only EV71 is associated with severe clinical manifestations and deaths. Effective antiviral treatment and vaccines are not available. High-quality monoclonal antibodies (mAbs) are necessary to improve the accuracy of the diagnosis of EV71. In this study, a mAb (designated 1D9) was generated using EV71 C5 strain virus particles as immunogens. Examined by indirect immunofluorescence assay (IFA) and Western blotting, 1D9 detected successfully all 11 subgenotypes of EV71 and showed no cross-reactivity to the four selected subgenogroups of Coxsackieviruses CAV4, CAV6, CAV10, and CAV16. A linear motif, R(3) VADVI(8), which is located at the N-terminus of the EV71 VP1 protein, was identified as the minimal binding region of 1D9. Alignment and comparison of the 1D9-defined epitope sequence against the listed sequences in the NCBI EV71 database indicated that this epitope R(3) VADVI(8) was highly conserved among EV71 strains, while no significant similarity was observed when blasted against the Coxsackieviruses. This suggests that the mAb 1D9 may be useful for the development of a cost-effective and accurate method for surveillance and early differentiation of EV71 from CAV16 infection.