In this report, magnetic Fe 3 O 4 nanoparticles were functionalized with chitosan-grafted-poly(ethylene glycol) methyl ether (CTS-mPEG) for paclitaxel (PTX) delivery. The Fe 3 O 4 nanoparticles were prepared via the chemical coprecipitation method and then coated with CTS-mPEG (Fe 3 O 4 @CTS-mPEG) by a simple method. The formation of Fe 3 O 4 @CTS-mPEG was characterized by several methods including proton nuclear magnetic resonance spectroscopy, Fourier transform infrared, and X-ray diffraction. Furthermore, the superparamagnetic properties of Fe 3 O 4 @CTS-mPEG were demonstrated by a vibrating sample magnetometer; the saturation magnetization reached 23 emu g -1 . The sizes and morphologies of Fe 3 O 4 and Fe 3 O 4 @CTS-mPEG nanoparticles were determined by transmission electron microscopy. The result indicated that Fe 3 O 4 @CTS-mPEGs were nearly spherical in shape with an average diameter of 20 nm, compared with the 12-nm Fe 3 O 4 particles. Especially, PTX was effectively loaded into the coated nanoparticles, 86.9±3.4% for drug loading efficiency, and slowly released up to 120 h. These results suggest the potential applications of Fe 3 O 4 @CTS-mPEG in the development of stable drug delivery systems for cancer treatment.
Adjustably biodegradable materials have gained much attention in biomedical applications. Among of them, various hydrogel-based scaffolds have applied for regenerating soft and hard tissues. In this study, according to differently biological properties of gelatin or chitosan as well as biphasic calcium phosphate nanoparticles (BCPNPs), several injectable nanocomposite hydrogels (INgel) were enzymatically fabricated from a phenolic chitosan derivative (PCD), phenolic gelatin derivative (PGD) and BCPNPs. According the change of H2O2 concentration with follow-up the time, the in situ formation of INgel was varied from 35 to 80 s. The degradation rate of the nanocomposite materials significantly related to in presence of collagenase that expended from 3 days to over one month depending on amount of the formulated PCD. The BCPNPs-encapsulated PCD-PGD INgel enhanced mineralization in the simulated biofluid. Fluorescent cytotoxicity assay indicated that the INgel was fabricated from a higher amount of the PGD resulting in a significant proliferation of bone marrow mesenchymal stem cells. These preliminary results exhibited a great potential of the INgel for bone regeneration.
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