A dual synergistic of curcumin and gelatin on thermal-responsive hydrogel based on Chitosan-P123 in wound healing application

Pham, Lyna; Dang, Le Hang; Truong, Minh Dung; Nguyen, Thi Hiep; Le, Ly; Le, Van Thu; Nam, Nguyễn Đăng; Bạch, Long Giang; Nguyen, Van Toan; Trân, Ngoc Quyên

doi:10.1016/j.biopha.2019.109183

Cited by 80 publications

(48 citation statements)

References 46 publications

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“…In comparison to Figure 4 a,b, there is a new sharp peak at 2170 cm −1 . This may be attributable to the intense hydrogen bonding between the curcumin with either silver ions or chitosan chains [ 22 ]. Moreover, there is a peak at 410 cm −1 related to the formation of silver nanoparticles [ 27 ].…”

Section: Resultsmentioning

confidence: 99%

“…To overcome this problem, curcumin can form composites with Chitosan. Previous reports investigated pH sensitivity [ 21 ]; wound healing [ 22 ] and drug release [ 23 ] of loading curcumin compound based chitosan hydrogel. Recently, chitosan hydrogel was developed by incorporating curcumin complexed with beta cyclodextrins as a wound dressing [ 24 ].…”

Section: Introductionmentioning

confidence: 99%

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Antibacterial Properties and pH Sensitive Swelling of Insitu Formed Silver-Curcumin Nanocomposite Based Chitosan Hydrogel

El‐Hady

Saeed

2020

Polymers

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A simple method was used to prepare curcumin/silver nanocomposite based chitosan hydrogel. In an alkaline medium, chitosan and chitosan nanocomposite hydrogels were prepared using the physical crosslinking method. The prepared hydrogels were stable for a long period at room temperature. In one step, silver nanoparticles were prepared insitu using silver nitrate solution and curcumin oxide within the hydrogel network formation. In the meantime, curcumin compound served as both a reducing and stabilizing agent. The structure and surface morphology of nanocomposite hydrogels were characterized by FTIR, SEM, and EDX analysis confirmed the formation of silver nanoparticles within the hydrogel network. Moreover, Images of TEM showed a spherical shape of silver nanoparticles with an average size of 2–10 nm within the matrix of the hydrogel. The formation mechanism of nanocomposite based hydrogel was reported. Besides that, the effect of chitosan and silver nitrate concentrations were studied. The swelling capacity of the prepared nanocomposite hydrogels was also performed at different pH of 4, 7, and 9. From the experimental results, the swelling capacity of hydrogels depends on the concentrations of chitosan and silver nitrate. The prepared composite based hydrogel exceeds a higher swelling degree than chitosan hydrogels at low pH. The antibacterial activity of the nanocomposite hydrogels was also examined; the results showed that the prepared nanocomposite hydrogels outperformed the pure chitosan hydrogels. This shows them to be a promising material for the biomedical field as a wound dressing and drug release.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Antibacterial Properties and pH Sensitive Swelling of Insitu Formed Silver-Curcumin Nanocomposite Based Chitosan Hydrogel

El‐Hady

Saeed

2020

Polymers

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“…Pham et al prepared thermal-responsive hydrogels from chitosan-Pluronic P123 loaded with curcumin and gelatin for wound healing [ 62 ]. The rheological analysis of the curcumin-loaded hydrogels and dual-loaded hydrogels demonstrated thermally-induced sol-gel transition feature.…”

Section: Curcumin-loaded Wound Dressingsmentioning

confidence: 99%

“…Furthermore, on day 18 the wound healing was approximately 99.76%. The hydrogel provided a moist environment which acts as the extracellular matrix suitable for cell migration into the hydrogel network thereby increasing epithelial cell migration and wound healing with reduced formation of scars [ 62 ].…”

Section: Curcumin-loaded Wound Dressingsmentioning

confidence: 99%

Polymer-Based Materials Loaded with Curcumin for Wound Healing Applications

2020

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Some of the currently used wound dressings have interesting features such as excellent porosity, good water-absorbing capacity, moderate water vapor transmission rate, high drug loading efficiency, and good capability to provide a moist environment, but they are limited in terms of antimicrobial properties. Their inability to protect the wound from microbial invasion results in wound exposure to microbial infections, resulting in a delayed wound healing process. Furthermore, some wound dressings are loaded with synthetic antibiotics that can cause adverse side effects on the patients. Natural-based compounds exhibit unique features such as good biocompatibility, reduced toxicity, etc. Curcumin, one such natural-based compound, has demonstrated several biological activities such as anticancer, antibacterial and antioxidant properties. Its good antibacterial and antioxidant activity make it beneficial for the treatment of wounds. Several researchers have developed different types of polymer-based wound dressings which were loaded with curcumin. These wound dressings displayed excellent features such as good biocompatibility, induction of skin regeneration, accelerated wound healing processes and excellent antioxidant and antibacterial activity. This review will be focused on the in vitro and in vivo therapeutic outcomes of wound dressings loaded with curcumin.

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“…In vitro experiments for each type of scaffold revealed that cell viability at 3 days was at least 90% for those including chitosan. In vivo experimentation was carried out in mice, rats, and ex vivo human skin explants, and resulted in some scaffolds performing better than the control groups, such as the curcumin-loaded gel [106] and catechol-loaded terpolymer [107], while the gelatin-crosslinked [108] scaffold performed more poorly than the controls. These results indicate that while chitosan-mixed scaffolds may function well in an in vitro environment, further experimentation must be conducted on their use in in vivo situations.…”

Section: Antibacterial Scaffoldsmentioning

confidence: 99%

Development of Novel Microenvironments for Promoting Enhanced Wound Healing

Scull

Brown

2020

Curr. Tissue Microenviron. Rep.

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Purpose of Review Non-healing wounds are a significant issue facing the healthcare industry. Materials that modulate the wound microenvironment have the potential to improve healing outcomes. Recent Findings A variety of acellular and cellular scaffolds have been developed for regulating the wound microenvironment, including materials for controlled release of antimicrobials and growth factors, materials with inherent immunomodulative properties, and novel colloidal-based scaffolds. Scaffold construction methods include electrospinning, 3D printing, decellularization of the extracellular matrix, or a combination of techniques. Material application methods include layering or injecting at the wound site. Summary Though these techniques show promise for repairing wounds, all material strategies thus far struggle to induce regeneration of features such as sweat glands and hair follicles. Nonetheless, innovative technologies currently in the research phase may facilitate future attainment of these features. Novel methods and materials are constantly arising for the development of microenvironments for enhanced wound healing. Keywords Wound microenvironment. Wound modulation. Chronic wounds. Biomaterials. Biomaterials for wound healing. Novel wound healing materials This article is part of the Topical Collection on Cell Behavior Manipulation

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A dual synergistic of curcumin and gelatin on thermal-responsive hydrogel based on Chitosan-P123 in wound healing application

Cited by 80 publications

References 46 publications

Antibacterial Properties and pH Sensitive Swelling of Insitu Formed Silver-Curcumin Nanocomposite Based Chitosan Hydrogel

Antibacterial Properties and pH Sensitive Swelling of Insitu Formed Silver-Curcumin Nanocomposite Based Chitosan Hydrogel

Polymer-Based Materials Loaded with Curcumin for Wound Healing Applications

Development of Novel Microenvironments for Promoting Enhanced Wound Healing

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