Antibacterial Properties and pH Sensitive Swelling of Insitu Formed Silver-Curcumin Nanocomposite Based Chitosan Hydrogel

Abstract

A simple method was used to prepare curcumin/silver nanocomposite based chitosan hydrogel. In an alkaline medium, chitosan and chitosan nanocomposite hydrogels were prepared using the physical crosslinking method. The prepared hydrogels were stable for a long period at room temperature. In one step, silver nanoparticles were prepared insitu using silver nitrate solution and curcumin oxide within the hydrogel network formation. In the meantime, curcumin compound served as both a reducing and stabilizing agent. The structure and surface morphology of nanocomposite hydrogels were characterized by FTIR, SEM, and EDX analysis confirmed the formation of silver nanoparticles within the hydrogel network. Moreover, Images of TEM showed a spherical shape of silver nanoparticles with an average size of 2–10 nm within the matrix of the hydrogel. The formation mechanism of nanocomposite based hydrogel was reported. Besides that, the effect of chitosan and silver nitrate concentrations were studied. The swelling capacity of the prepared nanocomposite hydrogels was also performed at different pH of 4, 7, and 9. From the experimental results, the swelling capacity of hydrogels depends on the concentrations of chitosan and silver nitrate. The prepared composite based hydrogel exceeds a higher swelling degree than chitosan hydrogels at low pH. The antibacterial activity of the nanocomposite hydrogels was also examined; the results showed that the prepared nanocomposite hydrogels outperformed the pure chitosan hydrogels. This shows them to be a promising material for the biomedical field as a wound dressing and drug release.

Physical and Antimicrobial Properties of Chitosan/Silver Nanoparticle Composite Hydrogels: Role of the Crosslinker

“…15 This behavior provides the possibility to use for applications such as drug delivery by adapting to different pH environments. 15,17 Synthesis of HTCC−Ag NP Hydrogels. The concentration of silver nitrate used in this process followed a careful optimization which relied on a visualization of the system using HR-SEM and was determined to be 0.1 M (Figure S3.1).…”

Antibacterial and UV Protection Properties of Modified Cotton Fabric Using a Curcumin/TiO2 Nanocomposite for Medical Textile Applications

“…Other bands are observed in the region between 1000 cm −1 and 1300 cm −1 . All bands could be ascribed to the configuration of the symmetric and asymmetric C-O-C groups [39].…”

Development of soy protein/sodium alginate nanogel-based cress seed gum hydrogel for oral delivery of curcumin

“…They found that the swelling degrees of curcumin-silver/chitosan hydrogel were higher than chitosan hydrogel at pH 4 and 7. This may be due to the presence of curcumin-silver nanoparticles in the hydrogel, which expands the formed hydrogel network [9]. But higher amounts of NGs and lower amount of hydrogel (15:85 and 20:80) reduced the swelling degree.…”

“…The presence of CSG hydrogel increases the number of hydrophilic groups, which results in more hydration and swelling [51]. The presence of NG: HYD ratio of 10:90, expands the composite network and increases the porous matrix, and consequently the composite absorbs more water [9]. Elhadi et al investigated the swelling properties of chitosan hydrogel based on curcumin-silver nanocomposite.…”