Development of Novel Microenvironments for Promoting Enhanced Wound Healing

Abstract

Purpose of Review Non-healing wounds are a significant issue facing the healthcare industry. Materials that modulate the wound microenvironment have the potential to improve healing outcomes. Recent Findings A variety of acellular and cellular scaffolds have been developed for regulating the wound microenvironment, including materials for controlled release of antimicrobials and growth factors, materials with inherent immunomodulative properties, and novel colloidal-based scaffolds. Scaffold construction methods include electrospinning, 3D printing, decellularization of the extracellular matrix, or a combination of techniques. Material application methods include layering or injecting at the wound site. Summary Though these techniques show promise for repairing wounds, all material strategies thus far struggle to induce regeneration of features such as sweat glands and hair follicles. Nonetheless, innovative technologies currently in the research phase may facilitate future attainment of these features. Novel methods and materials are constantly arising for the development of microenvironments for enhanced wound healing. Keywords Wound microenvironment. Wound modulation. Chronic wounds. Biomaterials. Biomaterials for wound healing. Novel wound healing materials This article is part of the Topical Collection on Cell Behavior Manipulation

Tailoring bioinks of extrusion-based bioprinting for cutaneous wound healing

“…Hence, great efforts have been paid for adding a cocktail of microenvironmental factors into bioprinted skin substitutes. Recently, platelet-rich plasma (PRP) and decellularized ECM serves as cocktails of soluble and non-soluble microenvironmental factors exhibiting promising potential for creating biomimetic natural skin environment [ 146 ].…”

An injectable thermosensitive hydrogel with a self-assembled peptide coupled with an antimicrobial peptide for enhanced wound healing

“…[1][2][3] As the skin is injured, the phenomena of bleeding and microorganism invasion are inevitable, which critically lead to wound infection, disrupting the self-healing mechanism of normal skin or endangering human lives. [4][5][6] Therefore, many significant efforts have been devoted to developing a multifunctional wound dressing aimed at infection control, efficient hemostasis and excellent would healing. 7,8 Selecting an excellent would dressing to meet the specific needs of different stages of healing is an important target.…”

Wound-Microenvironment Engineering through Advanced-Dressing Bioprinting

“…Even so, advanced dressings can fail to boost healing mechanisms because they encounter a hostile microenvironment rich in inflammatory cytokines and enzymes, such as collagenase, gelatinases, stromelysins and cell-membrane-associated MMPs (Matrix Metalloproteinases), which contribute to the rapid clearance of growth factors and cytokines in the wound area and are detrimental for cell viability. Therefore, engineering the microenvironment has been regarded as a paramount trend to enhance cell survival and burst-healing mechanisms by the constant release and diffusion of signaling proteins [ 15 ].…”