An injectable thermosensitive hydrogel with a self-assembled peptide coupled with an antimicrobial peptide for enhanced wound healing

Zhang, Mei; Feng, Tianqi; Wu, Huayue; Ma, Wenyue; Wang, Zhaoguo; Wang, Chunli; Wang, Yilong; Wang, Siyao; Lin, Hao lin

doi:10.1039/d2tb00644h

Cited by 28 publications

(21 citation statements)

References 71 publications

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“…Excellent skin healing promoting effect was observed in a mouse skin infection model (Figure 8D). [103] Wang et al prepared injectable hydrogels consisting of polylysine (𝜖-PL) and carboxymethyl chitosan (CMCS) for medical applications. [104] Similarly, Zhu et al designed a hydrogel consisting of carboxymethyl chitosan (CMC) and a peptide dendrimer AMP (G3KP).…”

Section: Self-assembled Peptide-based Hydrogelsmentioning

confidence: 99%

Section: Skin Wound Bacterial Infectionmentioning

confidence: 99%

“…Excellent skin healing promoting effect was observed in a mouse skin infection model (Figure 8D). [ 103 ] Wang et al. prepared injectable hydrogels consisting of polylysine ( ε ‐PL) and carboxymethyl chitosan (CMCS) for medical applications.…”

Section: Skin Wound Bacterial Infectionmentioning

confidence: 99%

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Advances of Antimicrobial Peptide‐Based Biomaterials for the Treatment of Bacterial Infections

Lai

Shan

2023

Advanced Science

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Owing to the increase in multidrug-resistant bacterial isolates in hospitals globally and the lack of truly effective antimicrobial agents, antibiotic resistant bacterial infections have increased substantially. There is thus an urgent need to develop new antimicrobial drugs and their related formulations. In recent years, natural antimicrobial peptides (AMPs), AMP optimization, self-assembled AMPs, AMP hydrogels, and biomaterial-assisted delivery of AMPs have shown great potential in the treatment of bacterial infections. In this review, it is focused on the development prospects and shortcomings of various AMP-based biomaterials for treating animal model infections, such as abdominal, skin, and eye infections. It is hoped that this review will inspire further innovations in the design of AMP-based biomaterials for the treatment of bacterial infections and accelerate their commercialization.

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Section: Self-assembled Peptide-based Hydrogelsmentioning

confidence: 99%

Section: Skin Wound Bacterial Infectionmentioning

confidence: 99%

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Advances of Antimicrobial Peptide‐Based Biomaterials for the Treatment of Bacterial Infections

Lai

Shan

2023

Advanced Science

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“…For instance, gelatin is liquid at 37 °C and gels below 30 °C [ 73 ], whereas poly(N-isopropyl acrylamide) (PNIPAM) is liquid at room temperature and gels at physiologic temperatures [ 74 ]. With the aim of designing self-forming antimicrobial hydrogels that enhance wound-healing, Feng and coworkers reported the development of PNIPAM hydrogels containing a joint peptide consisting of an AMP RRWRVIVKW and RADA16 (Ac-RADARADARADARADA-NH 2 ), termed RA-Amps [ 75 ]. The AMP used in this study was found to disrupt bacterial cell membranes and inhibit growth [ 76 , 77 ].…”

Section: Self-assembling Amp Hydrogelsmentioning

confidence: 99%

Recent Advances in Antimicrobial Peptide Hydrogels

Copling

Akantibila

Kumaresan

et al. 2023

IJMS

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Advances in the number and type of available biomaterials have improved medical devices such as catheters, stents, pacemakers, prosthetic joints, and orthopedic devices. The introduction of a foreign material into the body comes with a risk of microbial colonization and subsequent infection. Infections of surgically implanted devices often lead to device failure, which leads to increased patient morbidity and mortality. The overuse and improper use of antimicrobials has led to an alarming rise and spread of drug-resistant infections. To overcome the problem of drug-resistant infections, novel antimicrobial biomaterials are increasingly being researched and developed. Hydrogels are a class of 3D biomaterials consisting of a hydrated polymer network with tunable functionality. As hydrogels are customizable, many different antimicrobial agents, such as inorganic molecules, metals, and antibiotics have been incorporated or tethered to them. Due to the increased prevalence of antibiotic resistance, antimicrobial peptides (AMPs) are being increasingly explored as alternative agents. AMP-tethered hydrogels are being increasingly examined for antimicrobial properties and practical applications, such as wound-healing. Here, we provide a recent update, from the last 5 years of innovations and discoveries made in the development of photopolymerizable, self-assembling, and AMP-releasing hydrogels.

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“…The results suggest that F127/CA/Gx hydrogel can envelop cells for tissue engineering ( Yap and Yang, 2020 ). Prosthodontic-inspired photopolymerization stimulated by blue light is a gentle process for initiating the polymerization of monomers ( Chen et al, 2020 ; Downs et al, 2020 ; Feng et al, 2022 ), The blue light initiator in the hydrogel system commences hydrogel cross-linking. Human Bone contains 50%–70% inorganic calcium and phosphorus.…”

Section: Promoting Bone Regeneration By Hydrogelsmentioning

confidence: 99%

Recent advances in hydrogels-based osteosarcoma therapy

Tian

Feng

et al. 2022

Front. Bioeng. Biotechnol.

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Osteosarcoma (OS), as a typical kind of bone tumors, has a high incidence among adolescents. Traditional tumor eradication avenues for OS such as chemotherapy, surgical therapy and radiation therapy usually have their own drawbacks including recurrence and metastasis. In addition, another serious issue in the treatment of OS is bone repair because the bone after tumor invasion usually has difficulty in repairing itself. Hydrogels, as a synthetic or natural platform with a porous three-dimensional structure, can be applied as desirable platforms for OS treatment. They can not only be used as carriers for tumor therapeutic drugs but mimic the extracellular matrix for the growth and differentiation of mesenchymal stem cells (MSCs), thus providing tumor treatment and enhancing bone regeneration at the same time. This review focuses the application of hydrogels in OS suppression and bone regeneration, and give some suggests on future development.

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An injectable thermosensitive hydrogel with a self-assembled peptide coupled with an antimicrobial peptide for enhanced wound healing

Abstract: Wound dressing based on thermosensitive hydrogel shows advantages over performed traditional dressings such as rapid reversible sol-gel-sol transition property and the capacity of filling the irregular wound area. Herein, RA-Amps...

Cited by 28 publications

References 71 publications

Advances of Antimicrobial Peptide‐Based Biomaterials for the Treatment of Bacterial Infections

Advances of Antimicrobial Peptide‐Based Biomaterials for the Treatment of Bacterial Infections

Recent Advances in Antimicrobial Peptide Hydrogels

Recent advances in hydrogels-based osteosarcoma therapy

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