Fabrication and characterization of 3<scp>D</scp>‐printed elastic auricular scaffolds: A pilot study

Kim, Ha Yeong; Jung, Soo Yeon; Lee, Sang Jin; Lee, Hyun Jung; Truong, Minh Dung; Kim, Hansu

doi:10.1002/lary.27344

Cited by 18 publications

(12 citation statements)

References 35 publications

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“…The FBR was attributed to the polyurethane–macrophages interaction and results were variable between each animal [ 207 ]. Moreover, structures with sharper pore size distributions seem to enhance tissue ingrowth in vivo [ 208 ]. Furthermore, dendritic cell maturation was found to be higher in scaffolds with pore diameter of 40 µm compared to 90 µm, which led to a collagenous and avascular tissue [ 209 ].…”

Section: In Vivo Outcomes and Clinical Trialsmentioning

confidence: 99%

The Overview of Porous, Bioactive Scaffolds as Instructive Biomaterials for Tissue Regeneration and Their Clinical Translation

2020

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Porous scaffolds have been employed for decades in the biomedical field where researchers have been seeking to produce an environment which could approach one of the extracellular matrixes supporting cells in natural tissues. Such three-dimensional systems offer many degrees of freedom to modulate cell activity, ranging from the chemistry of the structure and the architectural properties such as the porosity, the pore, and interconnection size. All these features can be exploited synergistically to tailor the cell–material interactions, and further, the tissue growth within the voids of the scaffold. Herein, an overview of the materials employed to generate porous scaffolds as well as the various techniques that are used to process them is supplied. Furthermore, scaffold parameters which modulate cell behavior are identified under distinct aspects: the architecture of inert scaffolds (i.e., pore and interconnection size, porosity, mechanical properties, etc.) alone on cell functions followed by comparison with bioactive scaffolds to grasp the most relevant features driving tissue regeneration. Finally, in vivo outcomes are highlighted comparing the accordance between in vitro and in vivo results in order to tackle the future translational challenges in tissue repair and regeneration.

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Section: In Vivo Outcomes and Clinical Trialsmentioning

confidence: 99%

The Overview of Porous, Bioactive Scaffolds as Instructive Biomaterials for Tissue Regeneration and Their Clinical Translation

2020

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“…For more than twenty years, the field of auricular tissue engineering has investigated a wide variety of cell sources, polymer scaffolds and growth factors in vitro and in vivo with the hope of making present surgical procedures for auricular repair obsolete [1][2][3][4][5]. Current ear reconstruction implements the use of autologous costal cartilage, Medpor or other prostheses for the auricular framework [6][7].…”

Section: Introductionmentioning

confidence: 99%

An analytical study of neocartilage from microtia and otoplasty surgical remnants: A possible application for BMP7 in microtia development and regeneration

et al. 2020

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To investigate auricular reconstruction by tissue engineering means, this study compared cartilage regenerated from human chondrocytes obtained from either microtia or normal (conchal) tissues discarded from otoplasties. Isolated cells were expanded in vitro, seeded onto nanopolyglycolic acid (nanoPGA) sheets with or without addition of bone morphogenetic protein-7 (BMP7), and implanted in nude mice for 10 weeks. On specimen harvest, cartilage development was assessed by gross morphology, histology, and RT-qPCR and microarray analyses. Neocartilages from normal and microtia surgical tissues were found equivalent in their dimensions, qualitative degree of proteoglycan and elastic fiber staining, and quantitative gene expression levels of types II and III collagen, elastin, and SOX5. Microarray analysis, applied for the first time for normal and microtia neocartilage comparison, yielded no genes that were statistically significantly different in expression between these two sample groups. These results support use of microtia tissue as a cell source for normal auricular reconstruction. Comparison of normal and microtia cells, each seeded on nanoPGA and supplemented with BMP7 in a slow-release hydrogel, showed statistically significant differences in certain genes identified by microarray analysis. Such differences were also noted in several analyses comparing counterpart seeded cells without BMP7. Summary data suggest a possible application for BMP7 in microtia cartilage regeneration and encourage further studies to elucidate whether such genotypic differences translate to phenotypic characteristics of the human microtic ear. The present work advances understanding relevant to the potential clinical use of microtia surgical remnants as a suitable cell source for tissue engineering of the pinna.

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“…A breakthrough technology in the field of reconstructive surgery and implantology can be 3D-bioprintingdirect manufacturing of implants and organs of the required shape and functionality from biomaterials. A review of the current state of 3D-bioprinting shows that currently there are mainly experimental works on the search for effective biomaterials and synthesis processes, in practical surgery, bioprinting has not yet found direct application [13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

The Significance of Computer Modeling and 3D Printing Technology for Facial Ectoprosthetics

Cherebylo

Vnuk

Ippolitov

et al. 2020

Proceedings of the 30th International Conference on Computer Graphics and Machine Vision (GraphiCon 2020). Part 2

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The integration of information technologies in healthcare practice significantly changes the methods of diagnosis and treatment, the forms of interaction of doctors with patients and colleagues, the organization of treatment and recovery of health. The field of reconstruction of the auricle is still a huge challenge for facial plastic surgeons and requires at various techniques to find the best treatment for each patient. The paper describes the application of computer modeling and laser stereolithography technology in surgical practice for auricular surfaces ectoprosthetics. To improve the accuracy and quality of the surgical intervention the positioning of external prosthesis is applied with the aid of personal templates and computer navigation. The accuracy of ectoprosthesis positioning when using a plastic mask template was 0.3-0.4 mm, while computer navigation was 0.1 - 0.2 mm. Using personalized templates is a simpler and more intuitive way of positioning that does not require expensive computer navigation systems. This example of ectoprosthetics shows the possibilities of various reconstructions of facial organs, not only the ear, but also, for example, the nose, using computer modeling and 3d printing technologies

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Fabrication and characterization of 3D‐printed elastic auricular scaffolds: A pilot study

Abstract: NA. Laryngoscope, 2018.

Cited by 18 publications

References 35 publications

The Overview of Porous, Bioactive Scaffolds as Instructive Biomaterials for Tissue Regeneration and Their Clinical Translation

The Overview of Porous, Bioactive Scaffolds as Instructive Biomaterials for Tissue Regeneration and Their Clinical Translation

An analytical study of neocartilage from microtia and otoplasty surgical remnants: A possible application for BMP7 in microtia development and regeneration

The Significance of Computer Modeling and 3D Printing Technology for Facial Ectoprosthetics

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