An enzyme-linked immunosorbent assay (ELISA) for von Willebrand factor antigen (vWf-Ag) in canine plasma. Veterinary Immunology and Immunopathology 33, 145-154

The post-menopausal women described in this report were clinically considered to have hyperandrogenism due to the pathological pattern of marked body hair over the upper trunk. Treatment with GnRH was very effective at reducing the severity of the hirsuties. The post-menopausal women with hyperthecosis in this report had a high prevalence of cardiovascular disease. Since hyperandrogenism and insulin are considered risk factors for cardiovascular disease in premenopausal women with polycystic ovaries, we discuss the possible relationship between insulin and the post-menopausal ovary.

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SummaryThe urinary gonadotrophin and ovarian steroid excretion pattern was studied in five women taking an oral contraceptive formulation consisting of mestranol 50 jig and norethisterone 1 mg. Both the pretreatment and posttreatment cycles were normal. The ovulatory peak of luteinizing hormone (LH) during the treatment cycles was uniformly suppressed, but LH continued to be excreted within the normal range. In one fifth of the treatment cycles there was a pronounced and sustained rise of oestrogen output in the absence of ovulation, and in many of the other treatment cycles oestrogen levels suggested that active ovarian steroidogenesis was taking place.

A 9\m=1/2\-year-oldgirl with congenital asymmetry manifested by a larger right half of the body demonstrated diploid-triploid mosaicism of chromosomes from skin fibroblast cultures but normal leukocyte karyotypes. Mosaicism was found in cells from both the larger and smaller sides of her body. The association of congenital asymmetry and diploid-triploid mosaicism has been reported only twice but may be more common than previously recognized.Congeni tal asymmetry as a rec¬ ognizable clinical problem ap¬ pears to be rare. The term congenital asymmetry is preferable to either "hemihypertrophy" or "hemiatrophy," since there is usually no evidence of excessive growth on ei¬ ther side. Even the larger side is of¬ ten below average for chronologic age. Congenital asymmetry is fre¬ quently associated with anomalies of one or more organ systems, particu¬ larly the neurocutaneous and skeletal structures. Retroperitoneal tumors of the adrenal glands and kidneys are more frequent in these patients.17 Moreover, in 1953 Silver et als de¬ scribed a syndrome of congenital asymmetry, short stature, and pre¬ maturely elevated urinary gonadotrophin values in children. Silver's syndrome is now an established en¬ tity and was the subject of an exten¬ sive review in 1964.9 A 9V2-year-old girl with congenital asymmetry demonstrated a normal chromosome karyotype in peripheral blood lymphocytes and diploid (2n)-triploid (3n) chromosomal mosaicism in skin fibroblasts. To our knowledge 2n/3n chromosomal mosaicism in this condition has been reported only twice previously.10"11 Report of a Case This 9y2-year-old girl was admitted to the pediatrie service for a diagnostic eval¬ uation of congenital asymmetry, most no¬ ticeable in the face and extremities with the right side larger than the left (Fig 1). She was the product of an uncomplicated 36-week gestation and weighed 1,588 gm (3 lb 8 oz) at birth. A younger sibling was reportedly normal.The mother also had three children dur¬ ing a previous marriage, all of whom were said to have been normal physically and of superior intelligence. The mother and father were not available for chromosomal studies or blood typing. Our patient did not walk until 2 years of age, nor talk distinctly until age 5 years.On physical examination the weight was 29 kg (64 lb), height, 124 cm (49 in), and head circumference, 49.5 cm. The face appeared smaller on the left, the right side of the tongue being noticeably larger than the left. (Table 1).Additional physical findings included noticeable down-turning of the outer edges of the mouth (Fig 1, left), a soft systolic functional murmur at the third left interspace, and infantile sexual devel¬ opment. No breast tissue was palpable and the external genitalia appeared com¬ patible with her chronologic age. There was moderate thoracic scoliosis to the right which was confirmed by chest roentgenogram. The liver and spleen were not palpable. No abdominal masses were de¬ tected. There was clinodactyly with a single crease on the left fifth digit. The skin appeared normal...

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