ABSTRACT:A 3-month-old male kitten was presented to our clinic with malaise, vomiting and jaundice. In the anamnesis, we learned that the cat had a history of anorexia, sneezing, and nasal discharge and that the owner had administered 100 mg/day (t.i.d.) nimesulide orally for three days. In the laboratory study, high levels of serum alkaline phosphatase, γ-glutamyl transtransferase, total bilirubin, direct bilirubin, indirect bilirubin, urea, and creatinine were detected. All the clinical signs and laboratory abnormalities returned to normal levels after cessation of the nimesulide and supportive treatment. In this case, clinical and laboratory findings were thought to be compatible with nimesulide-induced acute biliary injury and renal failure. This case report indicates that the household pets are at risk of toxic drugs administered by their owners and great caution should be taken in administering NSAIDs in cats.
This study was aimed at evaluating the effects of Leishmania infection and AMB (amphotericin--B) treatment onhematological, biochemical and oxidative stress parameters in three Staffordshire Bull Terrier dogs with visceral leishmaniasis (VL). These dogs were presented with weight loss, weakness, and cutaneous lesions. Canine kala--azar detection kit was positive in dogs with VL. AMB was administered to cases with VL at a dose of 0.6 to 1.5 mg/kg/week for 4 months. Leishmania agents caused the liver injury due to increase in the ALT level in cases 1 and 2, decrease in erythrocyte, hemoglobin, and hematocrit level and increase in the MDA, and decrease in the GSH--Px in case 3, but Leishmania agents did not affect the kidney functions due to normal urea and creatinine level in the dogs with VL. A gradual response to the AMB treatment was observed. At the end of treatment course, cases with VL were treated clinically. It was concluded that the AMB administration for 4 months might be effective to treat VL due to no clinical recurrence for 6--month follow--up period.
Özet: İshalli 21 buzağıda mikro COı sistemi ve kan gazı analizörü kullanılarak sırasıyla venöz kan serumu total karbondioksit ve venöz kan bikarbonat değerleri ile metabolik asidozisin şekillenip şekillenmediği saptandı. Buzağııara verilecek sodyum bikarbonat miktarı her iki yöntem kullanılarak hesaplandı. Mikro CO ı sistemi ve kan gazı analizörü ile ölçülen bikarbonat değerleri arasında istatistiksel bir fark belirlenmedi ve %75 korelasyon saptandı (r= 0,758). Sonuç olarak, ishalli buzağııara verilecek sdyum bikarbonat miktarının mikro COı sistemi ile hesaplanmasının basit ve güvenilir bir yöntem olduğu kanısına varıldı.Anahtar kelimeler: Buzağı, ishal, kan gazı analizörü, mikro CO ı sistemi Determination of metabolie acidosis and sodium bicarbonate requirement by a micro CO ı system and a blood gase analyser in diarrheic ealves Summary: Blood serum total carbondioxide and venous blood bicarbonate values and the presence of metabolic acidosis were determined by a micro COı system and a blood gase analyser respectively in 21 diarrheic calves. The requirement of sodium bicarbonate given to diarrheic calves was cakulated by using both methods. There were no statistically significant differences and 75 % correlation (r=0.758) for the values of bicarbonate between the micro CO ı system and blood gase analyser. As a result, it was conC1uded that micro COı system was a simple and a safe method for estimating the requirement of sodium bicarbonate for diarrheic calves.
Hemorrhagic bowel syndrome is relatively common disease in dairy and beef cattle which has high fatality rate. It is classified as acute, sporadic and necrohemorrhagic enteritis. It is commonly seen in highly productive dairy cattle. The cause of hemorrhagic bowel syndrome is unclear and the pathogenesis is not well-understood. As a primary etiologic agent Clostridium perfringens type A has been strongly proposed and its alpha and beta2 toxin are suggested to have an important role in occurence of the disease. Disease especially observed in the first 3 months of lactation in lactating dairy cows. Ration is seem to be the most important predisposing factor in the development of hemorrhagic bowel syndrome. Severe toxemia (enterotoxemia) and intense hemorrhage in the small intestine cause pathological changes in the intestine. The blood clots in the intestinal lumen, a specific finding of hemorrhagic bowel syndrome can only be demonstrated in 19% of affected cows. Diagnosis is often based on the clinical, ultrasound and necropsy findings and also with differential diagnosis of other haemorrhagic enteritis caused by salmonellosis, Bovine Viral Diarrhea and coccidiosis etc. Prognosis is poor and fatality rate is nearly 100% despite intensive medical and surgical therapy. The use of feed additives, good nutritional management and vaccine administration are recommended for disease control. Sığırlarda hemorajik bağırsak sendromu ÖZ Hemorajik bağırsak sendromu, daha yaygın olarak sütçü ve etçi sığırlarda görülen ölüm oranı yüksek bir hastalıktır. Akut, sporadik ve nekrohemorajik enterit olarak sınıflandırılır. Süt verimi yüksek sığırlarda yaygın olarak görülür. Hemorajik bağırsak sendromu'nun nedeni belirsizdir ve patogenezi tam olarak anlaşılamamıştır. Primer etiyolojik etkenin Clostridium perfringens tip A olduğu ağırlıklı bir şekilde öne sürülmüş olup, etkenin alfa ve beta2 toksininin, hastalığın oluşumunda önemli bir rolü olduğu düşünülmektedir. Hastalık, özellikle laktasyondaki süt ineklerinde, laktasyonun ilk 3 ayında görülür. Rasyon, hemorajik bağırsak sendromu gelişiminde en önemli predispozan faktör olarak görülmektedir. İnce bağırsaklardaki şiddetli toksemi (enterotoksemi) ve yoğun hemoraji, bağırsaklarda patolojik değişikliklere neden olur. Spesifik bir hemorajik bağırsak sendromu bulgusu olan bağırsak lumenindeki kan pıhtılaşması, sendromdan etkilenen ineklerin sadece % 19'unda tespit edilebilir. Teşhis; genellikle klinik, ultrason ve nekropsi bulgularına dayanır ve teşhis, ayrıca salmonellozis, Bovine Viral Diarrhea ve koksidiyoz vb. kaynaklı diğer hemorajik enteritlerin ayırıcı tanısı ile olur. Prognoz kötüdür ve ölüm oranı, yoğun medikal ve şirurjikal tedaviye rağmen yaklaşık % 100'dür. Hastalığın kontrolü için yem katkı maddelerinin kullanımı, iyi beslenme yönetimi ve aşı uygulaması önerilmektedir.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.