Clinical Utility of Lactate in Calves with Bovine Respiratory Disease

Çamkerten, İlker; Börkü, Mehmet Kazım; Kalinbacak, Aslan; Borazan, G. O.; Şahin, Tülin; Aktaş, Mustafa Sinan

doi:10.3923/javaa.2010.1955.1957

Cited by 2 publications

(2 citation statements)

References 10 publications

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“…We suggest also lactate levels over 1.5 mmo/l being of high risk as out of 15 observed calves 10 died despite the treatment. Higher plasma lactate was found in calves with bovine respiratory diseases with signifi cantly higher values in calves which died (mean 4.53 mmol/l), than recovered (mean 2.15 mmol/l) [15]. Another study [16] in calves experimentally infected with bovine respiratory syncytial virus, the arterial blood lactate concentration was signifi cantly associated with lung disease.…”

Section: Discussionmentioning

confidence: 98%

“…Decreased delivery to the brain or heart can lead to collapse, and decreased delivery to other tissues leads to lactic acidosis and metabolic abnormalities [12]. However, there are only few data about the effects of hypoxia on blood lactate levels and, consequently, hypoxic lactacidemia and changes in acid-base balance in calves suffering from respiratory diseases [13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

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Blood Gases, Acid-Base Status And Plasma Lactate Concentrations In Calves With Respiratory Diseases

et al. 2015

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The purpose of this study was to evaluate in calves the effects of respiratory diseases of various severities on blood gases, acid-base balance and plasma lactate concentration. We included in the study 128 calves with clinical signs of various severities and outcomes of respiratory disorders. The age of the calves ranged from 1 to 12 months. According to the clinical fi ndings, course of the disease and time of blood collection, the sick calves were divided into three groups: RD 1 (n=34) -calves with moderate clinical signs; RD 2 (n=73) -calves with severe respiratory symptoms and RD 3 (n=21) -calves with severe respiratory symptoms and died within 48 hours after blood sampling. Into the study we also included one group of 28 clinically healthy calves. In the arterial blood we evaluated: blood pH, partial pressure of carbon dioxide -pCO 2 , partial pressure of oxygen -pO 2 , concentration of actual bicarbonate -HCO 3 -, base excess -BE, and saturation of hemoglobin by oxygen -O 2 -sat. The concentration of lactate was determined in the blood plasma. Signifi cant effects of health status and severity of respiratory diseases were recorded in all the evaluated variables. Marked hypoxemia and hypercapnia were found in calves with severe respiratory disorders and in animals that died within 48 hours after blood collection. In most calves, the acid-base changes were characterized as compensated respiratory acidosis. The highest mean lactate values were recorded in calves that died within 48 hours after blood sampling. The presented results suggest the usefulness of the analysis of blood gases and acid-base status in the evaluation and prognosis of various degrees and severity of respiratory diseases in calves, and in monitoring the patient response to treatment. Although plasma lactate analysis is less consistent with the severity of respiratory diseases, it might be helpful in the indication of an untreatable stage of the disease and upcoming death.

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Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Blood Gases, Acid-Base Status And Plasma Lactate Concentrations In Calves With Respiratory Diseases

et al. 2015

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Randomized comparison between a forced air system and warm water bath for resuscitation of neonatal hypothermic calves with or without oral administration of caffeine

Copeland,

Kreuder,

Dewell

et al. 2024

Veterinary Internal Medicne

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BackgroundHypothermia is a cause of neonatal calf death in cold climates. Practical and effective rewarming methods are important for bovine health within affected regions.Hypothesis/ObjectivesTo compare the rewarming rate and blood analytes (glucose, lactate, and cortisol) of calves resuscitated with forced air with warm water bath, with or without oral administration of caffeine.AnimalsTwenty healthy neonatal Holstein bull calves.MethodsIn this randomized, prospective study, calves born healthy and without history of dystocia were cooled to 32°C rectal temperature then thermally resuscitated using either forced air rewarming or warm water bath (40°C) with or without oral administration of caffeine. Rectal temperatures were used to quantify recovery rate. Measurements of glucose, lactate, and cortisol were recorded for every 2°C change in rectal temperature.ResultsRectal temperature decline (0.03°C per minute) and total cooling time (191.0 ± 33.3 minutes) did not significantly differ among treatment groups. Calves were successfully resuscitated to 38°C by either method. Time required to euthermia using warm water was significantly faster (0.1°C per minute; 64.3 ± 17.8 minute; P < .05) than forced air (0.05°C per minute; 123.1 ± 20.0 minutes). Caffeine had no significant effect on resuscitation rate (P = .14; 95% CI, −0.002 to 0.024) in either treatment; however, caffeine was associated with reduced time to euthermia by 8.3 and 10.8 minutes, respectively. Changes in metabolic variables (glucose, lactate, and cortisol), were inversely related to rectal temperature with no statistical significance among rewarming methods.Conclusions and Clinical ImportanceAlthough warm water submersion is faster, forced air rewarming is an effective alternative for restoration of euthermia.

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Clinical Utility of Lactate in Calves with Bovine Respiratory Disease

Cited by 2 publications

References 10 publications

Blood Gases, Acid-Base Status And Plasma Lactate Concentrations In Calves With Respiratory Diseases

Blood Gases, Acid-Base Status And Plasma Lactate Concentrations In Calves With Respiratory Diseases

Randomized comparison between a forced air system and warm water bath for resuscitation of neonatal hypothermic calves with or without oral administration of caffeine

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