Highlights
Despite their major effects on positive symptoms, antipsychotics do not have a significant effect on cognition in schizophrenia
Bilateral high frequency rTMS targeting dorsolateral prefrontal cortices has been effective on working memory
Bilateral 20 Hz rTMS improved attention and verbal working memory in schizophrenia patients,
It also improved the competence of switching the perceptional set up under a disruptive effect towards new instructions, in this study
Objectives: The aim of this study was to investigate the comorbidity of dissociative disorders in patients with bipolar disorder. Methods: Fifty-one patients who are diagnosed with bipolar disorder in euthymic state and forty-nine healty controls were included in the study. The Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I), Structured Clinical Interview for DSM-IV Dissociative Disorders (SCID-D), Dissociative Experiences Scale (DES) and Childhood Trauma Questionnaire (CTQ-28) were administered to all participants with a sociodemographic form. Results: Mean DES and CTQ-28 total scores were statistically higher in patients group than control group (p < 0.001 and p < 0.001, respectively). Emotional abuse, emotional neglect, physical abuse, physical neglect and sexual abuse subscale scores of CTQ-28 were higher in patients group than healthy controls group (p = 0.002, p < 0.001, p = 0.005, p < 0.001 and p < 0.021, respectively). The rate of any dissociative disorder comorbidity was 35.4% in patients with bipolar disorder. The most frequent dissociative disorder in patient with bipolar disorder was depersonalization disorder (17.6%). There was a positive correlation between DES score and number of suicidal attempts (r = 0.284). Negative correlations were found between DES score and age of disease onset, and CTQ-28 total score and age of disease onset (r =-0.332 and r =-0.291). Conclusion: Our results have shown that dissociative disorders may be frequently accompanied in patients with bipolar disorder. Dissociation and childhood traumatic events can be related with clinical features in patients with bipolar disorder.
Introduction: This study aims to compare sociodemographic characteristics of the patients with bipolar disorder (BD) with and without comorbid dissociative disorder (DD) and to investigate the eventual effect of the comorbidity on the treatment.
Methods:We enrolled a total of 149 patients diagnosed with BD and treated as inpatients consecutively in Şişli Etfal Hospital, Psychiatry Clinic between 2010 and 2011. For the patients who were diagnosed with DD using SCID-D and with BD using SCID-I, sociodemographic characteristics, YMRS, HAM-D, BPRS, DES scores and duration and number of hospital stays were evaluated. Results: 23 patients (15.4%) had dissociative disorder not otherwise specified (DD-NOS), 4 patients (2.6%) had dissociative identity disorder (DID) and 1 patient (0.6%) had dissociative amnesia. BD patients with comorbid DD were found to be predominantly female (p=0.015) and younger (p=0.002) and to have significantly higher DES scores than BD patients without DD (p<0.001). The total score of DES was correlated with duration hospital stay (p=0.001, Spearman r=0.336) in the total sample. Total HAM-D score at the time of admission was significantly higher in the comorbidity group (p=0.027), and suicide item was found to be significantly higher both at admission and at discharge (p<0.001 and p=0.035). Among BPRS scores at admission, hallucinatory behavior item was found to be higher in the comorbidity group (p=0.019). Among YMRS scores both at admission and at discharge, velocity and amount of speech item (p=0.027) and insight item at admission (p=0.006) was found to be significantly higher in the pure bipolar group (p=0.018).
Conclusion:In patients with BD, DD comorbidity should be investigated. The BD patients with DD comorbidity tend to be female and younger, and show higher depression scores, leading to a prolonged hospital stay. In the presence of dissociation comorbidity, attempts and number of suicides and hallucinatory behaviors seem to be increased.
It is suggested that in case of blockage in an energy center, illness or imbalance may occur and it may be treated by touching by hand according to Reiki. In this case, the first episode of psychosis with intense occupation of reiki will be presented. A 57 year-old woman presented with the complaints of auditory hallucinations, decreased need for sleep, and skepticism. In psychiatric examination; poor self-care, irritable affect, decreased psychomotor activity, flight of associations, mystic delusions, and auditory illusions were noted. It was her first psychiatric administration and her complaints were exacerbated 10 days ago. According to her family, the patient, who has no intimate friendship, has been busy with reiki for 4 years. As the level of reiki goes up, the patient, who predicts the increase of the auditory hallucinations as a reward, has tried to heal the patients through the energy and has tried to eat the earth and to throw herself from 3 meters high. For a possible organic etiology, no pathological findings were found in the results of the blood tests and cranial MRI. Haloperidol 20 mg/day, biperidene 4 mg/day quetiapine 100 mg/day was recommended for the patient who was diagnosed as atypical psychosis. Within a week, her complaints were down. The beginning of the psychotic manifestations of our case, such as hearing the voices, may suggest that a mission like healing in this ritual leads the patient to a psychotic life. From another point of view, the fact that the patient's introverted prodromal period may suggest that there is a psychotic pattern with negative symptoms in the beginning, and perhaps the patient may turn to this area for self-medication. It may be appropriate to evaluate Reiki healing technique from the perspective of psychosis in addition to healing activity.
Aim: The COVID 19 outbreak continues today with significant morbidity and mortality. Healthcare workers have the
highest risk in this epidemic. Therefore, vaccination was first started from healthcare workers. In this study, we aimed to
examine the antibody levels of healthcare workers after vaccination.
Material and Methods: This is a retrospective study. A total of 102 healthcare workers who were given CoronaVac vaccine
and whose antibody levels were checked after vaccination were included in the study.
Results: The seventy seven (75.5%) of the cases were male, 25 (24.5%) were female, the mean age was 43.25 ± 9.97. 8
(7.8%) of the cases had previously had COVID-19. The mean antibody level was 1768.02 ± 3586.09. Antibody mean in
women was 2127.9 ± 4716.1; it was 1651.2 ± 3163.8 in men. No statistical difference was found between age and gender
and antibody level (Respectively; p=0.564, p=0.596).
Conclusion: Post-vaccination antibody development was good among healthcare workers. All of the healthcare workers
who had COVID-19 had an antibody response. There were only 3 individuals who did not develop antibody response.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.