BACKGROUND AND PURPOSE:In the search for a diagnostic marker in ALS, we focused our attention on the hyperintense signal intensity in T1 MTC MR images along the CST, detected in some patients and not found in other patients with ALS and in control subjects. The aim of this study was to investigate the relationship between the hyperintense signal intensity in T1 MTC images and white matter damage. To this purpose, we studied potential heterogeneities in DTI values within our patients by using TBSS without a priori anatomic information.
Conclusions: These results suggest that open RFA may be a more effective technique as it is associated with a lower local recurrence rate, albeit with no effect upon overall survival. However, the percutaneous group had a significantly larger mean lesion size and this together with the fact that patients undergoing percutaneous procedures are often less fit, or have more advanced disease, may partly explain these results. Further studies with large, wellmatched cohorts are required to further investigate these findings.
Recurrence was greater with T3/4 disease compared to T1/2 disease (70% versus 60%) (p = 0.01).T1/2 disease in the <75 group was associated with fewer recurrences than <75 T3/4 disease group (p 0.001). Recurrence rates were comparable with T1/T2 disease and T3/T4 disease in the >75 years group (p = 0.190).There was no improvement in DFS with and without AC following hepatectomy in the >75 group (p = 0.161). However there was improved DFS between the <75 groups with AC and without AC (p 0.001). OS in the>75 group was improved in the group receiving AC compared to the >75 group not receiving AC (p = 0.023). Conclusions: In patients with CRLM, with advancing age, recurrence rates do not seem to be affected by the T stage. In addition, AC following hepatectomy does not appear to improve DFS survival with advancing age.
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