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FIG. 2.Altered apical surface expression or binding of M-cellmarkers and cell adhesion molecules in cocultures of Caco-2 and Raji B-cells compared with Caco-2 cell monocultures. Hatched bar indicates altered basolateral expression; black bars indicate altered apical expression/binding. The results are expressed as % change compared to Caco-2 monocultures (ϭ 0%), n ϭ 4-6; n.e., not expressed; *P Ͻ 0.05, **P Ͻ 0.01.

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The fluxes of mannitol, TRH, dexamethasone, FD-4, FD-10 and FD-20 across the Caco-2 monolayer were significantly enhanced when electric field was applied. The iontophoretic effect appeared to be directly upon tight junctions

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