No abstract

No abstract

No abstract

No abstract

843tion over the blood vessels of the chorioallantoic membrane and area vasculosa as described elsewhere(5-7). A test period of 24 hours was used during which time the yolk sac tumors nearly doubled in size. The effect on growth was evaluated on the basis of the increased size of embryo and tumor which occurred in the control eggs during the period of the experiment. A total of 320 tumorbearing eggs involving 12 separate experiments was used in these tests.Results. Table 1 records the results with 2 Rain-lily extracts and aminopterin. Aqueous and alcohol extracts of the plant were ineffective. Negative results were also obtained with a solution of liquid pressed from the plant bulbs at high pressure.It will be noted in the table that the Rainlily extracts gave about the same order of inhibition of tumor growth as did aminopterin but without the inhibition of the embryo growth which characterized the action of the latter compound.Discussion. The chemical nature of the effective agent in these Rain-lily extracts will be explored. It is known that an alkaloid with fungicidal action is present in plants of this group. To obtain this material, dry powdered bulbs are extracted with 95% ethanol (8). In the present work ethanol extracts of fresh bulbs were ineffective in the tests on cancer growth. There is apparently a seasonal factor involved since extracts of bulbs collected in the Austin area in the late Spring after the plant was advanced in growth were ineffective. S U~~Q Y Y .Extracts of Rain-lily bulbs have been tested for their effect on the growth of tumor and embryo of tumor-bearing eggs. The results obtained with aminopterin in the same tests are included for comparison. Acid aqueous and acetone extTacts of the plant bulb inhibited tumor growth 81% and 9476, respectively, without affecting the embryo. Aminopterin inhibited tumor growth 87% and embryo growth 19%.