"Crystalline" Virus-Like Particles from Skin Papillomas Characterized by Intranuclear Inclusion Bodies.

Strauss, Maurice J.; Shaw, Ernest W.; Bunting, Henry; Melnick, Joseph L.

doi:10.3181/00379727-72-17328

Cited by 132 publications

(40 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Crystal-like formations have been observed by differential centrifugation of material from human infectious skin papilloma (17,18) as well as in sections of ceils of this lesion (1,19). The intranuclear inclusion bodies of some such cells have been found to contain DNA (20,21) which is acquired during a developmental stage of the inclusion (22,23).…”

Section: Bloch~ Morgan~ Godman Howe and Rosementioning

confidence: 99%

A Correlated Histochemical and Electron Microscopic Study of the Intranuclear Crystalline Aggregates of Adenovirus (Ri-Apc Virus) in Hela Cells

Bloch

Morgan

Godman

et al. 1957

The Journal of Cell Biology

View full text Add to dashboard Cite

HeLa cells in tissue cultures infected with types 3, 4, or 7 of adenovirus (RI-APC virus) were studied in order to correlate certain histochemical and electron microscopic findings. Adjacent thin (ca. 0.05 µ) and thick (2–4 µ) sections of osmium-fixed, methacrylate-embedded cells were cut; by mapping the sections the same cells could be identified with both the electron and the light microscope. Intranuclear crystalline aggregates seen with the electron microscope to be composed of ordered arrays of viral particles were found by means of the Feulgen reaction to contain DNA. DNA is therefore assumed to be a constituent of the viral particle. The virus appeared to develop from an osmiophilic Feulgen-negative matrix. Displacement of nuclear chromatin occurred during this process. A Feulgen-azure staining method was found to permit clear distinction between viral and nuclear (host) DNA in thick sections.

show abstract

Section: Bloch~ Morgan~ Godman Howe and Rosementioning

confidence: 99%

A Correlated Histochemical and Electron Microscopic Study of the Intranuclear Crystalline Aggregates of Adenovirus (Ri-Apc Virus) in Hela Cells

Bloch

Morgan

Godman

et al. 1957

The Journal of Cell Biology

View full text Add to dashboard Cite

show abstract

“…Although human papillomavirus was already identified as virions in skin warts by electron microscopy in 1949 [24], it took approximately 30 years before HPV-DNA from condylomata accuminata was characterised and cloned [25][26][27]. Eventually, this led to the discovery of associated HPV sequences in cervical cancer [28].…”

Section: Human Papillomavirusesmentioning

confidence: 99%

Detection, management, and follow‐up of pre‐malignant cervical lesions and the role for human papillomavirus

Hamont

Bekkers

Massuger

et al. 2007

Reviews in Medical Virology

View full text Add to dashboard Cite

Cervical cytological pathology is common. Prevention of cervical cancer by detecting the disease process at an early and pre-malignant stage is practised globally either through population-based screening programmes (PSP) or through non-organised ones. High-grade cervical intraepithelial neoplasia (CIN) detected by cervical cytological screening is extensively visualised by colposcopy and successively treated by, for instance, large loop electro-surgical excision of the transformation zone. Persistent infections with certain high-risk human papillomavirus (hr-HPV) genotypes play an essential role in cervical cancer carcinogenesis by mechanisms discussed in this review. HPV assessment, either DNA detection or HPV genotyping, could enhance the current cervical cancer screening programmes. Furthermore, primary prevention of cervical cancer through the introduction of HPV vaccines looks promising although the current vaccines merely protect against two hr-HPV genotypes, leaving a niche for at least 11 other hr-HPV's. Cervical screening in the post-vaccination era cannot be abolished but could be altered, as discussed in this review. Algorithms with the primary objective of hr-HPV testing followed by subjective cytology assessment in HPV-positive women could be a solution for both pre- and post-vaccination screening.

show abstract

“…The electron microscopic appearance of viral particles in human warts has been demonstrated by several authors (2,4,5,13,15,23,31).…”

Section: Introductionmentioning

confidence: 99%

Virus-like particles in papillomas of the human oral cavity

Frithiof

Wersäll

1967

Archiv f Virusforschung

View full text Add to dashboard Cite

"Crystalline" Virus-Like Particles from Skin Papillomas Characterized by Intranuclear Inclusion Bodies.

Cited by 132 publications

References 0 publications

A Correlated Histochemical and Electron Microscopic Study of the Intranuclear Crystalline Aggregates of Adenovirus (Ri-Apc Virus) in Hela Cells

A Correlated Histochemical and Electron Microscopic Study of the Intranuclear Crystalline Aggregates of Adenovirus (Ri-Apc Virus) in Hela Cells

Detection, management, and follow‐up of pre‐malignant cervical lesions and the role for human papillomavirus

Virus-like particles in papillomas of the human oral cavity

Contact Info

Product

Resources

About