A herpes-type virus infection, the first to be found in an invertebrate animal, is reported in the oyster Crassostrea virginica. Intranuclear herpes-type viral inclusions were more prevalent in the oyster at elevated water temperatures of 28 degrees to 30 degrees C than at normal ambient temperatures of 18 degrees to 20 degrees C. The inclusions were associated with a lethal disease at the elevated temperatures.

A transplantable reticulum cell sarcoma with leukemic manifestations can be transmitted from one hamster to another by means of a mosquito, Aëdes aegypti (L.). The transmission seems to be by a transfer of tumor cells, and not by passage of some other oncogenic agent.

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A virus of the pox group was isolated from a lesion on a patient with milker's nodules by use of tissue cultures of bovine cells. The virus shows marked biologic and serologic differences from vaccinia virus, and it is presumably the etiologic agent of the milker's nodule syndrome.

TUDIES OF biochemical abnormalities in alcaptonuria during the course of S almost a century culminated recently in the demonstration that the basic defect is absence of homogentisic acid (HGA) oxidase in the tissues.l The mechanisms involved in the pathologic consequences of this biochemical defect have, however, been little studied or understood.The pathologic characteristics of the arthropathy that constitutes the principal lesion of ochronosis have been described in scattered instances.2 The anatomic findings in the knees in three cases that we have studied have suggested a number of mechanisms by which the alcaptonuric defect may cause pigmentation and damage to articular tissues. These observations as well as electronmicroscopic and certain in vitro studies of the reaction between articular cartilage and HGA provide the basis of the present report.CASE REPORTS Alcaptonuria in the three patients was proven by the reduction of Brigg's reagent by urine, and by enzymatic assay for HGA in both blood and urine.8 CASE 1. (No. 01-63-68). The patient was a 44 year old man dying of bronchogenic carcinoma. The clinical and hereditary aspects of this case have been reported previously.' At the age of 38 the patient began having severe pains in the low back, and two years later noted pain and grating sensations when moving the knees. Roentgenographic studies at this time revealed narrowing of the joint space between the patella and femur, osteophytes, and roughening of the articular surface of the patella. Radiopaque bodies were present in the suprapatellar and popliteal spaces.

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