Further observations on the virus of epizootic diarrhea of infant mice

Banfield, William G.; Kasnic, George; Blackwell, John

doi:10.1016/0042-6822(68)90166-9

Cited by 54 publications

(23 citation statements)

References 7 publications

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“…Distinctive particles interconnected by thin filaments (Type V) have not previously been described in calf intestines infected with rotavirus, but they have been reported in mouse tissue infected with E D I M virus (Adams & Kraft, 1967;Banfield et al 1968). Filaments of similar appearance have also been observed in association with both orbivirus and reovirus grown in tissue culture (Lecatsas,I968a,b).…”

Section: ~2mentioning

confidence: 74%

“…In particular, particles with and without the distinctive outer shell have been observed in mice infected with epizootic diarrhoea (EDIM) virus (Adams & Kraft, !967;Banfield, Kasnic & Blackwell, 1968) and children infected with a non-bacterial gastroenteritis (Bishop et al 1973 ;Holmes et al 1975). Particles with a clear outline have not, however, been identified in piglets infected with a calf rotavirus (Hall et al I976), or in a previous study of calf intestine infected with a calf rotavirus (Stair et al 1973).…”

Section: ~2mentioning

confidence: 99%

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Different Particle Types in Tissue Culture and Intestinal Epithelium Infected with Rotavirus

Chasey

1977

Journal of General Virology

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SUMMARYRotavirus-infected intestinal epithelial cells in vivo and calf kidney cells in vitro have been examined by electron microscopy. Morphogenesis takes place in the cytoplasm and several particle types are observed. These can be classified broadly into two groups, one of which appears to represent the characteristic normal development of infectious virus and the other, distinctly different, which may be a non-infectious form. Two of the particle types are tentatively identified as the ' single' and ' double' capsid rotavirus particles seen typically in negatively stained preparations.

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Section: ~2mentioning

confidence: 74%

Section: ~2mentioning

confidence: 99%

Different Particle Types in Tissue Culture and Intestinal Epithelium Infected with Rotavirus

Chasey

1977

Journal of General Virology

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“…There is evidence for this from published studies on rotavirus morphogenesis. Tubular structures have been observed in thin sections of infected cells both in the cytoplasm and in the nuclei and they may be identical to those seen in negatively stained preparations (Banfield et al, 1968;Suzuki & Konno, 1975;Saifet al, 1978;Pearson & McNulty, 1979;Rodriguez-Toro, 1980;Suzuki et al, 1981). It is clear, however, that the complexity of rotavirus morphogenesis (Chasey, 1977;Esparza et al, 1980;Petrie et al, 1981) is reflected also in the variety of related aberrant tubular structures, although the characterization of the protein components of rotatubes is a necessary prerequisite for their formal identification as specific components of the rotavirus capsid.…”

Section: Discussionmentioning

confidence: 98%

Electron Microscopy of Tubular Assemblies Associated with Naturally Occurring Bovine Rotavirus

Chasey¹,

Labram²

1983

Journal of General Virology

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“…This protected the underlying lamina propria, which otherwise would have been completely denuded. The magnitude of cellular loss was indicated by (1) the large number of infected cells in the feces [ 191, and (2) the fact that the type of epithelium covering the villi was reduced to a cuboidal or squamous type so that more area was covered. The microvilli on these cells were altered also, being clubshaped, widely spread, irregular in length and spacing, and increased in diameter.…”

Section: Discussionmentioning

confidence: 99%

Neonatal Calf Diarrhea. Electron Microscopy of Intestines Infected with a Reovirus-Like Agent

et al. 1973

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Abstract. Neonatal calf diarrhea induced by a reovirus-like agent was studied by electron microscopy. Gnotobiotic calves were inoculated with virulent and cell-cultureadapted isolates of viruses, and similar results were obtained with both isolates. The virus infected mature villous epithelial cells of the small intestine and replicated predominantly within cisternae of the endoplasmic reticulum. Macrophages within small intestinal villi also contained viral particles. Shedding of virus into the feces apparently resulted from desquaniation of infected epithelial cells. Replacement epithelium did not contain the reovirus-like agent, was of cuboidal or squamous type, and ultrastructurally resembled immature epithelium normally found in the crypts. Escherichia coli was nonpathogenic when inoculated alone and did not adhere to the epithelium when inoculated with the virus. The reovirus-like agent was a primary pathogen since it caused diarrhea and lesions when inoculated alone or with E. coli.Diarrhea of neonatal calves has been a serious and persistent problem of the dairy industry for many years. This disease has become a major problem on ranches with cow-calf operations. Apparently an increased frequency of neonatal calf diarrhea in beef-type calves has been caused by calving during a relatively short period of time in the late winter and early spring when inclement weather causes stress. Cows and their offspring have been concentrated into small areas during the calving season, and transmission of infectious diseases to susceptible calves has been favored.A virus designated initially as neonatal calf diarrhea virus was isolated in 1968 and reported as an etiologic agent in field cases of neonatal calf diarrhea [9]. The disease was reproduced experimentally in specific pathogen-free and gnotobiotic calves inoculated with bacteria-free filtrates obtained from infected calves. Fecal material purified by ultracentrifugation and examined by

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Further observations on the virus of epizootic diarrhea of infant mice

Cited by 54 publications

References 7 publications

Different Particle Types in Tissue Culture and Intestinal Epithelium Infected with Rotavirus

Different Particle Types in Tissue Culture and Intestinal Epithelium Infected with Rotavirus

Electron Microscopy of Tubular Assemblies Associated with Naturally Occurring Bovine Rotavirus

Neonatal Calf Diarrhea. Electron Microscopy of Intestines Infected with a Reovirus-Like Agent

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