Mosquito Transmission of a Reticulum Cell Sarcoma of Hamsters

Banfield, William G.; Woke, Paul A.; Mackay, Carol M.; Cooper, Herbert L.

doi:10.1126/science.148.3674.1239

Cited by 50 publications

(32 citation statements)

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“…A spontaneously arising sarcoma was found to be transmissible among a colony of Syrian hamsters (Brindley and Banfield, 1961;Cooper et al, 1964), and this cancer could even be experimentally transferred between individuals by mosquitoes (Banfield et al, 1965). A number of mouse cancer cell lines can be propagated by intraperitoneal injection through unrelated mouse strains (Carry et al, 1979;Hicks et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

Clonally transmissible cancers in dogs and Tasmanian devils

2008

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Tasmanian devil facial tumor disease (DFTD) and canine transmissible venereal tumor (CTVT) are the only known naturally occurring clonally transmissible cancers. These cancers are transmitted by the physical transfer of viable tumor cells that can be transplanted across histocompatibility barriers into unrelated hosts. Despite their common etiology, DFTD and CTVT have evolved independently and have unique life histories and host adaptations. DFTD is a recently emerged aggressive facial tumor that is threatening the Tasmanian devil with extinction. CTVT is a sexually transmitted tumor of dogs that has a worldwide distribution and that probably arose thousands of years ago. By contrasting the biology, molecular genetics and immunology of these two unusual cancers, I highlight the common and unique features of clonally transmissible cancers, and discuss the implications of clonally transmissible cancers for host-pathogen evolution.

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Section: Discussionmentioning

confidence: 99%

Clonally transmissible cancers in dogs and Tasmanian devils

2008

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“…The lack of major histocompatability antigens or their down regulation would promote the chance of tumour emergence (Murgia et al, 2006;Siddle & Kaufman, 2015). Looking into the literature, I found only one example of 'naturally' transmissible tumours, reported 50 years ago, among inbred strains of laboratory rodents; this was a histiocytic leukaemia in Syrian hamsters and remarkably, it could be transmitted by mosquitoes (Banfield et al, 1965).…”

Section: Transmissible Tumour Cellsmentioning

confidence: 99%

What's the host and what's the microbe? The Marjory Stephenson Prize Lecture 2015

Weiss

2015

Journal of General Virology

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“…The existence of contagious cancer is well known among dogs and other canines, [8] Tasmanian devils, [9] Syrian hamster, [10,11] sea lions (genital carcinoma), sea turtles (fibropapillomatosis), beluga whales, bottom-dwelling fish [12,13] and so on. Venereal cancer of dogs is usually transmitted when dogs mate, resulting in the direct physical intrusion of viable cancerous matter from an afflicted dog to a healthy one.…”

Section: Origin and Transmissibility Of Animal Cancermentioning

confidence: 99%

“…The transfer of these circulating cells from tumor-bearing hamsters to hamsters without tumors leads to the transmission of the next tumor [11]. According to chromosome studies [10,11], the cells of all tested cancerous animals had identical, very consistent and highly specific tumor karyotype differing from the normal pattern for hamster cells.…”

Section: Origin and Transmissibility Of Animal Cancermentioning

confidence: 99%

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Human cancer is transmitted via genome

Rumyantsev¹

2013

OJGen

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Recent discredit of "somatic mutation" hypotheses forced the need of new paradigms about the nature of human cancer. The present article is devoted to further development of one such paradigm: the hypothesis of invasive parasitic nature, origin, evolution, pathogenesis and transmission of human cancer. Development was performed by supplementing and supporting the hypothesis by data which could not be applied before. The supplementation included integrative reconsidering, and reinterpretation of the make-ups, traits and processes existing not only in human cancer but also in animal cancers. Special attention has been focused on xenogamous intrusion of carcinogenic traits in the genome of a host. It was evidenced that human cancer possesses the same set of traits characteristic of transmissible animal cancer. In contrast to animal cancer formed of solitary cell lineage, human cancer consists of a couple of lineages constructed under different genetic regulations and performed different structural and physiological functions. The diversity of cancer composition remains stable over sequential propagation. The subsistence of human cancer regularly includes obligatory rotation alternation of its successive forms including genomic, gametic, zygotic, micro-population and tumorous ones. Human cancer possesses its own biological watch and the ability to gobble its victim, transmit via the intrusion of the genome, perform intercommunications within the tumor components and between the dispersed subunits of cancer.

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Mosquito Transmission of a Reticulum Cell Sarcoma of Hamsters

Abstract: A transplantable reticulum cell sarcoma with leukemic manifestations can be transmitted from one hamster to another by means of a mosquito, Aëdes aegypti (L.). The transmission seems to be by a transfer of tumor cells, and not by passage of some other oncogenic agent.

Cited by 50 publications

References 1 publication

Clonally transmissible cancers in dogs and Tasmanian devils

Clonally transmissible cancers in dogs and Tasmanian devils

What's the host and what's the microbe? The Marjory Stephenson Prize Lecture 2015

Human cancer is transmitted via genome

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