Overall aims of this research was to study the antibacterial activity of Voacanga foetida and then studied the distribution of the alkaloidal lombine produced in the plant, in which the samples were collected from three different regions. The antibacterial activities were assayed using agar well diffusion method. The distribution of the alkaloids in Voacanga foetida, especially lombine was studied on the basis of GC-MS in several temperature programs. The result showed that the leaves and the barks of Voacanga foetida were possessing antibacterial properties. The second result, GC-MS showed that alkaloidal lombine was produced stably in the barks while not in the leaves. The abundance of lombine in the base fraction of the barks was 6.06% (West Lombok), 74.91% (East Lombok), and 2.77% (North Lombok). The outcome will be then used as a platform for further studies investigating total uses of the plant especially in finding new materials for medicine.
A quantitative structure-activity relationship (QSAR) analysis of meisoindigo derivatives as a breast anticancer has been carried out. This study aimed to obtain the best QSAR model in order to design new meisoindigo based compounds with best anticancer activity. The semiempirical PM3 method was used for descriptor calculation. The best QSAR model was built using multilinear regression (MLR) with enter method. It was found that there were 19 new meisoindigo derivativeswith better predictive a potent anticancer agent. The best compound was (E)-2-(1-((3-ethylisoxazol-5-yl)methyl)-2-oxoindolin-3-ylidene)-N-(4-methoxyphenyl)acetamide with the value of IC505.31144 x10-15 (μM).
Xanthones are one of the biggest classes of compounds in natural product chemistry. Xanthones have been isolated from pericarp mangosteen (Garcinia mangostana L.) and then purified with VLC using calcium oxide (CaO) as the stationary phase and eluted using n-hexane: EtOAc of increasing polarity. Extraction of the pericarp mangosteen using the maceration method with acetone as the solvent. The isolation of xanthones was carried out through various chromatography techniques, such as vacuum liquid chromatography (VLC), gravitational column chromatography (GCC), and thin layer chromatography (TLC). The molecular structure of the compound was identified based on spectroscopy data, including IR, 1D NMR (1H and 13C), and 2D NMR (HSQC and HMBC). Based on the analysis of spectrum data, the isolated compound is ɑ-mangostin. The acetone extract and ɑ-mangostin were also examined for antibacterial activity against Gram positive (+) Staphylococcus aureus (S. aureus) ATCC 25923 and Gram negative (-) Escherichia coli (E. coli) ATCC 25922. The largest inhibition zone was shown by ɑ-mangostin against S. aureus (12.16 mm) more than E. coli (12 mm).
ABSTRAK. Penelitian ini bertujuan untuk menganalisis kandungan senyawa kimia khususnya kandungan metabolit sekunder dari ekstrak metanol akar, batang, dan daun Nicotiana tabacum asal pulau lombok. Analisis dilakukan dengan menggunakan Gas Chrommatography-Mass Spectrophotometry (GCMS). Hasil analisis menunjukkan ada beberapa senyawa metabolit sekunder dari golongan alkaloid dan terpenoid. Nikotin atau 3-(1-metil-2-pirolidinil) piridin merupakan salah satu senyawa mayor yang berhasil diidentifikasi dengan % area masing-masing untuk akar, batang, dan daun berturut turut 18,35 %, 20,90 %, dan 40,59 %. Selain nikotin ada lima jenis senyawa alkaloid dari turunan asam nikotinat yang berhasil diidentifikasi, diantaranya; nikotrin, miosmin, anabasin, anatalin, dan 2,3'-bipiridin. Kelima senyawa alkaloid ini memiliki konsentrasi yang kecil. Selanjutnya pada ekstrak metanol akar dan daun Nicotiana tabacum juga berhasil diidentifikasi senyawa dari golongan terpenoid. Senyawa terpenoid tersebut yaitu leden dengan kerangka seskuiterpen dan b-4,8,13-duvatriene-1,3-diol dengan kerangka diterpenoid siklik. Nilai % area masing-masing adalah 0,46% dan 7,19 %. _____________________ ABSTRACT.This study aims to analyze the content of chemical compounds, especially the content of secondary metabolites from methanol extract of roots, stems, and leaves of Nicotiana tabacum from Lombok island. The analysis was carried out using Gas Chromatography-Mass Spectrophotometry (GCMS). The results of the analysis showed several compounds from the alkaloid group, fatty acids and its derivatives, terpenoids, and alcohol. Nicotine or known as 3-(1-methyl-2-pyrrolidinyl)-pyridine is one of the major compounds that was successfully identified with % area from roots, bark and leaves respectively 18.35%, 20.90%, and 40, 59%. Besides nicotine, there are five types of alkaloid compounds which are derivatives of nicotinic acid that have been successfully identified. Furthermore, In the methanol extract of Nicotiana tabacum roots and leaves, compounds from the terpenoid group have also been identified. There are leden from sesquiterpen and b-4,8,13-duvatriene-1,3-diol from the cyclic diterpenoid. The % area value is 0.46% and 7.19%, respectively. _____________________ PENDAHULUANTembakau dengan spesies Nicotiana tabacum, merupakan jenis tanaman semak yang tumbuh di daerah dengan iklim tropis dan subtropis. Nicotiana tabacum secara komersil dibududayakan untuk memperoleh daun tembakau yang merupakan bahan dasar pembuatan rokok. Selain itu, secara etnobotani tanaman ini juga dimanfaatkan sebagai insektisida, obat penghilang rasa nyeri, obat penenang, obat sakit gigi, dermatitis, dan untuk pengobatan gangguan pencernaan (Rodgman and Perfetti, 2008;Groark, 2010).
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