Antibacterial Assay and Alkaloid Lombine Distribution Study of Voacanga foetida (B.I)Rolfe from Lombok Island

Abstract

Overall aims of this research was to study the antibacterial activity of Voacanga foetida and then studied the distribution of the alkaloidal lombine produced in the plant, in which the samples were collected from three different regions. The antibacterial activities were assayed using agar well diffusion method. The distribution of the alkaloids in Voacanga foetida, especially lombine was studied on the basis of GC-MS in several temperature programs. The result showed that the leaves and the barks of Voacanga foetida were possessing antibacterial properties. The second result, GC-MS showed that alkaloidal lombine was produced stably in the barks while not in the leaves. The abundance of lombine in the base fraction of the barks was 6.06% (West Lombok), 74.91% (East Lombok), and 2.77% (North Lombok). The outcome will be then used as a platform for further studies investigating total uses of the plant especially in finding new materials for medicine.

Vobtusine from Voacanga foetida (Blume) Rolfe Induces Apoptosis via Activation of Caspase Pathway in Human HL-60 Leukemia Cell Line

“…Bisindole alkaloids comprise two indole alkaloid monomers units joined by C-C, C-O-C, or C-N bonds [2], [3]. The plant contained high concentrations of alkaloids [4]. In continuation of our study on Sumatran plants [5][6][7][8][9][10][11][12].…”

Cytotoxic Activity, and Molecular Docking of Indole Alkaloid Voacangine and Bisindole Alkaloid Vobtusine, Vobtusine Lactone from the Indonesian Plant: Voacanga foetida (Blume) Rolfe

“…This plant is widely spread in Indonesia, Malaysia, and the Philippines. V. foetida leaves were generally used to treat various skin conditions such as wounds, itching, swelling, and have been used externally for skin disorders (Hadi et al, 2019).…”

The Anti-proliferation Effect of an Isolated Butanol Fraction of Tampa Badak (Voacanga foetida (Bl.) K. Schum) Leaves on Leukemia, Lung, and Cervical Cancer

“…Voacanga foetida (Bl) K. Schum (Apocynaceae), locally called 'Tampa badak,' is a plant species mainly distributed in Sumatra, Indonesia. The aqueous extract of V. foetida leaves or bark is commonly used to treat a wide range of skin conditions such as wounds, itches, swellings, and antimicrobial (Hadi et al, 2019).…”

“…Another study revealed that V. foetida leaves also have anti-inflammatory, antipyretic, and analgesic activity (Susanty et al, 2014). A recent study found that V. foetida leaves are also potential as anticancer (Susanty et al, 2018) because the rich in alkaloids, such as voacangine, coronadine, voacristine, lombine (Hadi, 2019), and vobtusine (Arbain, 2012), which these substances have a potent effect of cytotoxic activity. Therefore, we aimed to evaluate the cytotoxic effect of V. foetida leaves on several cancer cell types, including lung cancer, leukemia, and cervical cancer.…”