No abstract

No abstract

1 The effect of the novel P-adrenoceptor antagonist and vasodilator, carvedilol (SK&F 105517, -70 mg kg-' daily in the food), and captopril (-38 mg kg-' daily in the drinking fluid) on the progression of chronic renal failure in rats was studied.2 Six weeks following partial renal ablation, the urinary protein excretion of the carvediol-(60 ± 21 mg day-') and captopril-treated (35 ± 9 mg day-') animals was less than 50% that of control rats (133 ± 27 mg d-').3 Serum creatinine (Scr) and urea nitrogen (SUN) concentrations of the carvedilol-(Scr, 0.63 ± 0.09 mg dl'; SUN, 11.3 ± 1.2 mg dl-') and captopril-treated (Scr, 0.82 ± 0.05 mg d1-'; SUN, 14.1 1.5 mg dl-') animals were also significantly (P<0.05) lower than that observed in control animals (Scr, 1.4 ± 0.3 mg dl-'; SUN, 19.2 ± 3.9 mg dl-'), indicating that glomerular filtration rate was improved by both drugs. Plasma renin activity was significantly (P<0.05) higher in captopril-treated rats (24.7 ± 4.6 ng angiotensin I ml-' h-') than in either carvedilol-treated (7.9 ± 1.4 ng angiotensin I ml -' h-') or control animals (7.4 ± 1.0 ng angiotensin I ml1 ' h-'). 4 Histological examination of the kidneys demonstrated a significantly reduced glomerular hypertrophy and glomerulosclerosis in those animals receiving carvedilol or captopril compared to controls. 5 Serum carvedilol concentration measured every 6 h for 24 h was variable and ranged on average from 57 ± 13 ng ml-' at 16 h 00 min to 121 ± 31 ng ml1' at 03 h 00 min. These data indicate that the rats probably had 24 h systemic exposure to carvedilol. 6 The present study indicates that carvedilol is effective in attenuating the progression of chronic renal failure in rats.

No abstract

There are no pharmacokinetic grounds for adjusting dosages of either ropinirole or L-dopa when given in combination.

No abstract

No abstract

No abstract