Conflito de interesse: os autores declaram, em relação aos produtos e companhias descritos nesse artigo, não ter interesses associativos, comerciais, de propriedade ou financeiros que representem conflito de interesse. Licenciamento: Este artigo é publicado na modalidade Acesso Aberto sob a licença Creative Commons Atribuição 4.0 (CC-BY 4.0).
Objetivo: Avaliar as práticas pedagógicas no curso profissionalizante de Farmácia e Laboratório em escola de município de médio porte do interior paulista. Métodos: Realizado através de levantamento de dados fornecidos gentilmente por escola profissionalizante, a avaliação do conteúdo programático pedagógico ligado a profissionalização do curso de Farmácia e Laboratório Clínico. Resultados: Em avaliação crítica ao conteúdo pedagógico foi realizado divisão das disciplinas ministradas agrupadas em três áreas: formação básica, formação em laboratório clínico e formação em farmácia totalizando 14 módulos e as práticas relacionadas totalizando 21 atividades. As mudanças de mercado são constantes e cabe aos profissionais o acompanhamento destes. A profissionalização é uma das formas na qual o trabalhador busca para se manter ativo no mercado e ser capaz de competir com a concorrência. Conclusão: A partir das avaliações, frente ao conteúdo, é possível chegar à conclusão que as aulas práticas no curso profissionalizante de Farmácia e Laboratório são de grande importância na formação profissional do aluno, levando-o não só a compreender o processo como um todo, mas o desenvolvimento de um ser pensante, no qual está preparado para resoluções de problemas no cotidiano.
Health professionals are commonly exposed to risks associated with their craft; however, although their health is guaranteed by the Organic Health Law, there are several times if inappropriate, inefficient or neglected biosafety behaviors are observed. This article aimed to evaluate the facilities and working conditions of employees in a emergency unit, to identify the main occupational risks and to assist the perception of the competent bodies in the identification and reduction of risks of health promoting institutions. Through forms prepared from NR 32, the 112 employees of a emergency unit in the state of São Paulo were evaluated. The study was conducted with 82/112 (73.21%) of employees, with the distribution of positions among nursing technicians (70.7%), nurses (14.6%), and x-ray technicians (6, 1%) pharmacy technicians (4.9) and radiologists (3.7%). Structural disabilities in some sectors were identified during the evaluation, physical constraints compared to the number of attendances, restrictions on material collection and structural maintenance planning, as well as lack of staff preparation for some functions such as the use of fire extinguishers, or negligence regarding the use of personal protective equipment and deficiencies in sanitary protocols. Biosafety actions can prevent and reduce the risks associated with their craft, while also ensuring population and environmental health. This study can serve to guide projects and institutional protocols, with the purpose of reducing risks inherent to professionals and patients of health facilities.
The manool diterpene, found in abundance in Salvia of ficinalis L., showed a selective cytotoxic effect against murine melanoma cells. Therefore, the present study aimed to evaluate the antitumor potential of manool in a murine melanoma model, administered by three routes: oral, subcutaneous, and intraperitoneal. In addition, the antimelanoma effect of manool (orally) combined with cisplatin (subcutaneous) was evaluated. The results obtained revealed that manool, administered by the three routes, was able to significantly decrease the mass and frequency of mitosis of the tumor tissue. The data obtained revealed that manool, at a dose of 20 mg/kg, was able to significantly decrease the tumor mass when administered by the three routes, with the percentages of reduction being equivalent to 62.4% (oral), 48.5% (intraperitoneal), and 38.8% (subcutaneous), without toxic effects. The treatment of manool plus cisplatin led to 86.7% reduction in tumor mass, higher than that observed in treatment with manool or cisplatin alone (50.7%), although signs of toxicity have been observed. The results also showed that treatments with manool (20 mg/kg orally) and/or cisplatin did not alter the activity of caspase 3 cleaved in tumor tissue. Therefore, manool revealed a promising antimelanoma effect, but without involvement of the caspase 3 cleaved pathway.
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