The methanolic extracts from the wood and bark of Cotylelobium melanoxylon were found to inhibit plasma glucose elevation after sucrose loading in rats and triglyceride elevation after olive oil loading in mice. (vaticanols A, E, and G) were isolated from the bark extract of C. melanoxylon. The principal constituents, vaticanols A, E, and/or G, inhibited plasma glucose and triglyceride elevation after sucrose loading in rats and olive oil loading in mice, respectively. In addition, vaticanols A, E, and/or G inhibited the enzyme activities of rat intestinal a a-glucosidase, porcine pancreatic lipase, and rat lens aldose reductase.
Other natural products U 0800Antidiabetogenic Constituents from the Thai Traditional Medicine Cotylelobium melanoxylon -[isolation and structure determination of the new stilbene dimer, melanoxylin A (I) and the stilbene trimer, melanoxylin B (II), together with nine known compounds as well as inhibitory effects of some principal constituents on the increase in plasma glucose levels and towards selected enzymes]. -(MATSUDA, H.; ASAO, Y.; NAKAMURA, S.; HAMAO, M.; SUGIMOTO, S.; HONGO, M.; PONGPIRIYADACHA, Y.; YOSHIKAWA*, M.; Chem. Pharm. Bull. 57 (2009) 5, 487-494; Kyoto Pharm. Univ., Misasagi, Yamashina, Kyoto 607, Japan; Eng.) -H. Toeppel 42-197
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