Periodontal Therapy by Local Delivery of Antibiotics. Periocline Administration in Periodontal Pocket in Combination with Scaling.

Ueda, Mitsuharu; Teranishi, Yoshihiro; Nakagaki, Naoki; Isaka, Miho; Kai, Tomoyuki; Hongo, Masako; Arakida, Tetsuji; Tanida, Masahiro; Tani, Mari; Yamaoka, Akira; Inoue, Jun-ichi; Doi, Masahide; Hattori, Hitoshi; Fukushima, Hajime; Sagawa, Hirosuke

doi:10.2329/perio.34.3_695

J Jpn Soc Periodontol

1992

DOI: 10.2329/perio.34.3_695

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Periodontal Therapy by Local Delivery of Antibiotics. Periocline Administration in Periodontal Pocket in Combination with Scaling.

Mitsuharu Ueda¹,

Yoshihiro Teranishi²,

Naoki Nakagaki³

et al.

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Subgingival Distribution of Periodontopathic Bacteria in Adult Periodontitis and Their Susceptibility to Minocycline‐HCl

Hagiwara¹,

Takamatsu²,

Tominaga³

et al. 1998

Journal of Periodontology

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The purpose of this study was to investigate the distribution of several periodontopathic bacteria in adult periodontitis, their in vitro susceptibility to minocycline‐HCl, and whether the efficacy of the drug changes with a decrease in bacterial susceptibility. Twenty‐one patients (43 to 75 years old) with 62 periodontal lesions from pockets ≥4 mm participated in the study. After subgingival sampling, an ointment containing 2% minocycline‐HCl was applied locally to the selected pockets once a week for 4 weeks. The lesions were clinically examined after 1 and 4 weeks of administration. The distribution of the subgingival microorganisms included Capnocytophaga sputigena (37.1%), Prevotella intermedia (22.6%), Porphyromonas gingivalis (22.6%), Fusobacterium nucleatum (20.1%), Actinobacillus actinomycetemcomitans (9.7%), and Eikenella corrodens (4.8%). The distribution was complex, with 76.8% of the sites containing 1 to 3 bacterial spieces. The minimum inhibitory concentration (MIC) of minocycline‐HCl for each organism showed that most were inhibited by a minocycline‐HCl concentration equal to or less than the MIC for reference strains. However, some clinical strains of Prevotella intermedia seemed to exihibit low susceptibility to minocycline‐HCl. There were no significant differences among sites with strains exhibiting low or normal susceptibility to minocycline‐HCl. The concentration of the drug applied to deep periodontal pockets inhibited the growth of most of the microorganisms investigated in this study. J Periodontol 1998;69:92–99.

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Subgingival Distribution of Periodontopathic Bacteria in Adult Periodontitis and Their Susceptibility to Minocycline‐HCl

Hagiwara¹,

Takamatsu²,

Tominaga³

et al. 1998

Journal of Periodontology

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数洋¹,

光男²,

章雄³

et al. 2011

J Jpn. Soc. Laser Dent.

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Background and Objective : In recent years, there has been growing interest in the use of dental lasers for treatment of periodontal diseases. The purpose of this clinical trial was to evaluate the effects of antimicrobial photodynamic therapy (aPDT) with indocyanine green (ICG) loaded nanospheres as photosensitizer for periodontal treatment. Material and Methods : Seventeen patients (56.1±10.3 years of age) participated in this study. Intended sites were taken from periodontally involved sites with a probing depth of ≥ 5 mm totaling 51 sites. These sites were divided into three groups at random. The laser with nanospheres group consisted of 17 sites irradiated with a diode laser at 0.5 W for 90 sec per site after injecting nanospheres into the periodontal pocket. The optical fiber was inserted into the periodontal pocket 1 mm less than the probing depth with surface anesthesia and moved up and down in order to irradiate the root surface as evenly as possible. The laser group consisted of 17 sites that were irradiated with the diode laser at 0.5 W for 90 sec per site. The sham group consisted of 17 sites that were not irradiated, but the fiber was only inserted into the periodontal pockets and moved up and down. Each subject was monitored clinically at baseline, 1 month, and 3 months. Clinical parameters such as probing pocket depth (PPD) , clinical attainment level (CAL) , and bleeding on probing (BOP) were measured at each site with a stent. Results : The mean value of the PPD significantly decreased in the laser with nanospheres group from 5.23±0.75 to 3.71±

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Periodontal Therapy by Local Delivery of Antibiotics. Periocline Administration in Periodontal Pocket in Combination with Scaling.

Cited by 2 publications

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Subgingival Distribution of Periodontopathic Bacteria in Adult Periodontitis and Their Susceptibility to Minocycline‐HCl

Subgingival Distribution of Periodontopathic Bacteria in Adult Periodontitis and Their Susceptibility to Minocycline‐HCl

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