Visceral leishmaniasis is a major, life-threatening parasitic disease that still remains a serious public health problem in Ethiopia. Understanding the epidemiological, clinical, and hematological profiles of visceral leishmaniasis patients is important for implementing evidence-based control strategies. It is also important for early treatment and to decrease the mortality rate from the disease. Therefore, this study was aimed at assessing the epidemiological, clinical, and hematological profiles of visceral leishmaniasis among patients visiting Tefera Hailu Memorial Hospital, Northeast Ethiopia. A retrospective study was conducted at Tefera Hailu Memorial Hospital from September 2017 to August 2021. Data were collected from the medical records of suspected patients who were tested by the rK39 rapid diagnostic by strictly following standard operating procedures. The data was summarized using Microsoft Excel and analyzed using SPSS 26 version software. Descriptive statistics were used to describe the epidemiological, clinical, and hematological profiles of visceral leishmaniasis patients. A p-value < 0.05 was considered statistically significant. The overall positivity rate for visceral leishmaniasis was 23.4% (132/564). The result of this study indicated a fluctuating yet declining trend in VL over the past 4 years. From a total of 132 VL confirmed cases, the numbers of cases were highest among males (78.0%), those 15–29 years of age (37.1%), and urban residents (89.4%). Furthermore, Abergele (11.0%), Sehala (6.0%), and Ziquala (5.0%) districts had the highest number of VL cases. The major clinical presentations of patients were fever (96.2%), splenomegaly (94.7%), and general weakness (80.3%). With regard to hematological profiles, the most common findings were anemia (86.4%), thrombocytopenia (81.8%), leucopenia (78.8%), neutropenia (74.2%), and pancytopenia (71.2%). In the study area, the VL positivity rate was high. Our findings also concluded that VL causes significant alterations in clinical and hematological parameters. Therefore, the zone health office and other concerned stakeholders should strengthen evidence-based control programs for VL.

Background Dyslipidemia refers to a lipid profile disturbance due to decreased high-density lipoprotein cholesterol and elevated low-density lipoprotein cholesterol, triglycerides, and total cholesterol. Helicobacter pylori infection can lead to some appetite-related disorders that may cause deregulated absorption of nutrients in the digestive system, contributing to changes in serum lipids. The purpose of this study is to assess dyslipidemia and its associated factors among H. pylori -infected patients attending at University of Gondar Comprehensive Specialized Hospital. Methods A comparative cross-sectional study was conducted on 231 H. pylori -positive and control groups, which were included by the convenience sampling technique from March to May 2021 at University of Gondar Specialized Hospital. Sociodemographic and behavioral characteristic data were collected using a pretested questionnaire, and 5mL of venous blood were used to determine the lipid profiles using DxC 700 AU chemistry analyzer. The data were analyzed using SPSS version 25. Mann–Whitney U -test and multivariable logistic regression were applied, and P-value <0.05 is considered statistically significant. Results The magnitude of dyslipidemia among H. pylori -infected patients was 71.8% (95% CI: 62.7–79.7). There was a statistically significant difference in lipid profiles between H. pylori -infected patients and control groups. The median (IQR) of lipid profiles in H. pylori -infected patients and control groups were for low-density lipoprotein: 108 (89.8, 145.5) vs 95 (79.45, 115.8, P<0.001), for triglycerides: 93 (65,117) vs 83 (58.5, 102, P=0.031), and cholesterol: 143 (119.5, 169,) vs 125 (110,143, P<0.001) mg/dl, respectively. Helicobacter pylori infection, alcohol drinking, unable to read and write, primary school, and secondary school were a significant associated variables with dyslipidemia (P<0.05). Conclusion There was a median lipid profile statistically significant difference between H. pylori -positive and control groups. Helicobacter pylori infection, educational status, and alcohol drinking habit had statistically significant association with dyslipidemia.

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Objective The aim of study is used to assess the association between Metabolic syndrome and its associated factors among dyspeptic patients at Tefera Hailu Memorial General Hospital, Sekota, North-East Ethiopia.Methods The study was a cross-sectional study design from March 01/2022 to May 30/2022. The study subjects were selected by convenient sampling technique. The data were entered into Epi. data 3.1 and analyzed using SPSS version 25. Logistic regression analysis was conducted and, P-value < 0.05 was used as a statistically significant variable.Results Our study included 228 study participants. The total prevalence of metabolic syndrome among study participants was 23.2%. Metabolic syndrome was statistically significantly associated with fasting blood glucose level(AOR: 15.965, 95% CI: 7.605–33.515), P < 0.001. The median serum level of low-density lipoprotein cholesterol (p < 0.001), triglyceride (P = 0.036), SBP(< 0.001and total cholesterol (P < 0.001) was a statistically significant difference between H. pylori positive and negative study participants.

Background: Dyslipidemia refers to a lipid profile disturbance due to decreased high-density lipoprotein cholesterol and elevated low-density lipoprotein cholesterol, triglycerides, and total cholesterol. H. pylori infection can lead to some appetite-related disorders and significant changes in body weight. For this reason, H. pylori infection may cause deregulated absorption of nutrients in the digestive system, contributing to changes in serum lipids. The purpose of this study is to assess dyslipidemia and its associated factors among Helicobacter Pylori infected patients attending at University of Gondar Comprehensive specialized hospital.Methods: A comparative cross-sectional study was conducted on 231 H. pylori positive and control groups which were included by the convenience sampling technique from March to May 2021 at University of Gondar specialized hospital. Sociodemographic and behavioral characteristic data were collected using a pretested semi structured questionnaire. About 5ml of venous blood were used to determine the lipid profiles using DxC 700 AU chemistry auto analyzer (Beckman Coulter, USA). The data were entered into Epi-data version 4.6 and analyzed using SPSS version 25. Mann-Whitney U test was used to compare the median of the continuous variables. Multivariable logistic regression analysis was done to determine the associated factors of dyslipidemia. P-value <0.05 is considered statistically significant.Results: The magnitude of dyslipidemia among Helicobacter pylori-infected patients was 71.8% (95% CI: 62.7-79.7). There was a statistically significant difference in lipid profiles between Helicobacter pylori-infected patients and control groups. The median (IQR) of lipid profiles in Helicobacter pylori-positive patients and control groups were for low-density lipoprotein: 108 (89.8, 145.5) vs 95 (79.45, 115.8, P<0.001), for triglycerides: 93 (65,117) vs 83 (58.5, 102, P=0.031), and cholesterol: 143 (119.5, 169,) vs 125 (110,143, P<0.001) mg/dl respectively. Helicobacter pylori infection (95%CI: 1.637-6.966), alcohol drinking (95%CI: 2.616-36.467), unable to read and write (95%CI: 1.384-14.077)), primary school (95%CI: 1.026-9.170), and secondary school (95%CI: 2.167-10.571) were a significant associated variables with dyslipidemia (P<0.05).Conclusion: There was a median lipid profile statistically significant difference between H. pylori positive and control groups. H. pylori infection, educational status, and alcohol drinking habit had statistically significant association of dyslipidemia.