Dyslipidemia and its associated factors among Helicobacter Pylori-infected Patients Attending at University of Gondar Comprehensive Specialized Hospital, Gondar, North- West Ethiopia: A Comparative Cross-Sectional Study

Abstract

Background: Dyslipidemia refers to a lipid profile disturbance due to decreased high-density lipoprotein cholesterol and elevated low-density lipoprotein cholesterol, triglycerides, and total cholesterol. H. pylori infection can lead to some appetite-related disorders and significant changes in body weight. For this reason, H. pylori infection may cause deregulated absorption of nutrients in the digestive system, contributing to changes in serum lipids. The purpose of this study is to assess dyslipidemia and its associated factors among Helicobacter Pylori infected patients attending at University of Gondar Comprehensive specialized hospital.Methods: A comparative cross-sectional study was conducted on 231 H. pylori positive and control groups which were included by the convenience sampling technique from March to May 2021 at University of Gondar specialized hospital. Sociodemographic and behavioral characteristic data were collected using a pretested semi structured questionnaire. About 5ml of venous blood were used to determine the lipid profiles using DxC 700 AU chemistry auto analyzer (Beckman Coulter, USA). The data were entered into Epi-data version 4.6 and analyzed using SPSS version 25. Mann-Whitney U test was used to compare the median of the continuous variables. Multivariable logistic regression analysis was done to determine the associated factors of dyslipidemia. P-value <0.05 is considered statistically significant.Results: The magnitude of dyslipidemia among Helicobacter pylori-infected patients was 71.8% (95% CI: 62.7-79.7). There was a statistically significant difference in lipid profiles between Helicobacter pylori-infected patients and control groups. The median (IQR) of lipid profiles in Helicobacter pylori-positive patients and control groups were for low-density lipoprotein: 108 (89.8, 145.5) vs 95 (79.45, 115.8, P<0.001), for triglycerides: 93 (65,117) vs 83 (58.5, 102, P=0.031), and cholesterol: 143 (119.5, 169,) vs 125 (110,143, P<0.001) mg/dl respectively. Helicobacter pylori infection (95%CI: 1.637-6.966), alcohol drinking (95%CI: 2.616-36.467), unable to read and write (95%CI: 1.384-14.077)), primary school (95%CI: 1.026-9.170), and secondary school (95%CI: 2.167-10.571) were a significant associated variables with dyslipidemia (P<0.05).Conclusion: There was a median lipid profile statistically significant difference between H. pylori positive and control groups. H. pylori infection, educational status, and alcohol drinking habit had statistically significant association of dyslipidemia.