Serum lipid profile of stroke patients attending at Dessie comprehensive specialized hospital, Dessie, Northeast Ethiopia: A comparative cross-sectional study

Alemayehu, Ermiyas; Fasil, Alebachew; Nigatie, Marye; Ambachew, Sintayehu

doi:10.1016/j.heliyon.2023.e14369

Cited by 3 publications

(3 citation statements)

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“…These findings are similar to those of a study carried out in Nigeria that reported dyslipidemia as the major cause of stroke and reported high abnormalities in high-density lipoprotein cholesterol (HDL-C) (74.5%) among stroke patients [39]. In Ethiopia, more than half of stroke patients were diagnosed dyslipidaemia, and LDL-C abnormalities are more common in these patients than in those with other lipid profiles [40]. In Ghana, lipid profiles among CVD patients in tertiary institutions were reported, similar to our findings where abnormalities in LDL-C were reported [41].…”

Section: Association Of Lipid Profile Abnormalities and Cvdssupporting

confidence: 88%

Lipid Profile Alterations and Predisposing factors associated with Cardiovascular Diseases at Kibagabaga District Hospital, Rwanda: A cross sectional study

Yadufashije,

Yolanda,

Mwanzia

et al. 2024

Preprint

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Background: Cardiovascular disease (CVD) is a public health concern. The World Health Organization reported that approximately 17.9 million deaths result from CVD annually, accounting for 31% of all deaths globally. Methods: A cross-sectional study with 100 simple randomly selected participants was conducted. Blood samples were collected to analyze lipid profiles, such as high-density lipoprotein (HDL-C), triglyceride (TG), total cholesterol (TC), and low-density lipoprotein (LDL-C) levels, of participants at the Kibagabaga District Hospital Biochemistry Laboratory. The questionnaire was used to record the predisposing factors associated with CVDs. The Statistical Package for Social Sciences (SPSS) version 22 was used for data analysis. Analysis of variance (ANOVA) was used to test for mean differences, while the chi-square test was used to assess associations between variables. Results: Most of the participants (38%) were aged 51-60 years and were male (51%) or female (49%). Coronary heart disease (CHD) was the most prevalent CVD (62%) and affected 32% of males and 30% of females, while it accounted for 27% of the population aged 51-60 years. In all the four CVDs, LDL-C had the highest abnormal cases and stood at 97% (n=100), with 59 cases in CHD (n=62), 20 cases in stroke (n=20), 10 cases (n=10) in Ischemic Heart Disease (IHD), and 8 cases (n=8) in Heart Failure (HF). The mean difference resulting from the variation in abnormal lipid profiles according to age group (Fcal=14.54327, p=0.001328; Fcrit=4.066181) and sex (Fcal=57.02564, p=0.000971; Fcrit=6.591382) was statistically significant. Alterations in HDL-C (x2=17, p=0.000698, 95% CI: 2.1, 22.9) were significantly associated with CVD incidence. Among the predisposing factors, only hypertension [(x2=10, 95% CI: (3.6, 21.4), p=0.01853] was significantly associated with CVD incidence. Conclusion: Coronary heart disease was a common CVD, and alterations in lipid profiles were observed among CVD patients, with LDL-C being the most abnormal. Among the predisposing factors, hypertension was the significant contributing risk factor to CVDs. Regular monitoring of lipid profiles is recommended, and patients should respect the advice of physicians to prevent long-term morbidity and further complications of the disease.

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Section: Association Of Lipid Profile Abnormalities and Cvdssupporting

confidence: 88%

Lipid Profile Alterations and Predisposing factors associated with Cardiovascular Diseases at Kibagabaga District Hospital, Rwanda: A cross sectional study

Yadufashije,

Yolanda,

Mwanzia

et al. 2024

Preprint

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“…Stroke is a severe neurological disorder that may arise when the blood supply to the brain is disrupted either by a blockage of a blood vessel (ischemic stroke) or by a rupture or leakage of a blood vessel (hemorrhagic stroke) (1). Approximately 88% of strokes are ischemic, while the remaining 12% consist of hemorrhagic strokes, which can be further classified as either subarachnoid (9%) or intracerebral (3%).…”

Section: Introductionmentioning

confidence: 99%

“…It leads to ischemic stroke as a result of thrombus, embolism, or conditions that result in low systemic perfusion pressures within cerebral vessels. Additionally, dyslipidemia can compromise the integrity of small blood vessels, increasing the likelihood of aneurysms and spontaneous cerebral or non-traumatic hemorrhage (1,7,13,14). Hence lowering LDL levels to target, can significantly reduce the risk of cerebral infarction and stroke (7).…”

Section: Introductionmentioning

confidence: 99%

Prevalence and pattern of dyslipidemia among patients with ischemic stroke in a tertiary care center in south- south Nigeria

Chibuike Eze Nwafor,

Nicole Onep-Onne Ogbak

2024

World J. Bio. Pharm. Health Sci.

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Background: Stroke is a major public health problem worldwide. Dyslipidemia is a significant risk factor for ischemic stroke, but its prevalence and characteristics in this population remain understudied. Therefore, this study aims to investigate the prevalence and patterns of dyslipidemia among individuals diagnosed with ischemic stroke in a tertiary care center in South-South Nigeria. Materials and Method: This is a retrospective hospital-based study on Ischaemic stroke patients admitted to GoodHeart Medical Consultant Hospital, Port- Harcourt, Rivers state, Nigeria, from July 2022 to June 2023. Results: The study comprised 33 subjects consisting of 18(54.5%) males and 15(45.5%) females. The mean age of the total population was 62.6 ± 12.49. The most prevalent age group was elderly (>61 years) 20 (60.6%). The females were older than the males with a mean age of 64.1 ± 2.50 and 61.3 ± 12.69 respectively. The overall prevalence of dyslipidaemia was 97%, whereas the most common form of dyslipidaemia was reduced HDL (57.6%). There was no significant difference in dyslipidaemia among male and female stroke patients, nevertheless 63.6% of the males had dyslipidaemia. Conclusion: Dyslipidaemia was common in the overall study population particularly reduced HDL and elevated LDL. The study revealed no statistically significant difference between gender and dyslipidaemia in stroke patients, nevertheless dyslipidaemia was more in the male stroke patients than females. Hence, prevention of dyslipidaemia as well as other risk factors is key to reducing the burden of stroke in our country.

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Investigating the Relationship between Lipid Profiles of Stroke Patients at the Time of Admission and Their Outcome

Rajabpour,

Ala,

Sadeghi-Hokmabadi

et al. 2024

OBM Neurobiol

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Hyperlipidemia is one of the critical risk factors for cerebrovascular disease. Many studies have emphasized that controlling the lipid level can decrease the risk of cardiovascular and cerebrovascular events. In this article, we studied all types of lipids in stroke patients and wanted to consider any relation between lipid level in admission and outcome. This retrospective, cross-sectional study was conducted at Imam Reza Research and Training Hospital. It was performed on a sample of 2165 patients who visited the emergency department and were admitted with a diagnosis of acute stroke (ischemic, hemorrhagic, subarachnoid hemorrhage) from 20<sup>th</sup> 2020 up to 20<sup>th</sup> 2023. Patients with underlying neoplastic disease, trauma, or coagulation disorders, who visited the emergency department with non-stroke signs and symptoms, and also who had incomplete documents were excluded from the study. The data of this study was extracted from the Tabriz stroke registry. In this study, 2165 patients were included. There is a significant relationship between age and other variables with most outcomes, but it does not show a strong relationship. There is a substantial relationship between the modified Rankin Scale and other variables with most outcomes, but it does not show a strong relationship. Between the follow-up modified Rankin Scale and other variables, there is a significant relationship with most of the outcomes, but it does not show a strong relationship. With most outcomes, there is a substantial relationship between the outcome and other variables, but it does not show a strong relationship. The initial lipid profile of patients at the time of entering the emergency department did not show a significant relationship with the outcome and length of the patient’s hospitalization of none of ischemic and hemorrhagic strokes. None of the candidate patients had received thrombolytic therapy.

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Serum lipid profile of stroke patients attending at Dessie comprehensive specialized hospital, Dessie, Northeast Ethiopia: A comparative cross-sectional study

Cited by 3 publications

References 40 publications

Lipid Profile Alterations and Predisposing factors associated with Cardiovascular Diseases at Kibagabaga District Hospital, Rwanda: A cross sectional study

Lipid Profile Alterations and Predisposing factors associated with Cardiovascular Diseases at Kibagabaga District Hospital, Rwanda: A cross sectional study

Prevalence and pattern of dyslipidemia among patients with ischemic stroke in a tertiary care center in south- south Nigeria

Investigating the Relationship between Lipid Profiles of Stroke Patients at the Time of Admission and Their Outcome

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