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A class of potent, nonsteroidal, selective indazole ether-based glucocorticoid receptor modulators (SGRMs) was developed for the inhaled treatment of respiratory diseases. Starting from an orally available compound with demonstrated anti-inflammatory activity in rat, a soft-drug strategy was implemented to ensure rapid elimination of drug candidates to minimize systemic GR activation. The first clinical candidate 1b (AZD5423) displayed a potent inhibition of lung edema in a rat model of allergic airway inflammation following dry powder inhalation combined with a moderate systemic GR-effect, assessed as thymic involution. Further optimization of inhaled drug properties provided a second, equally potent, candidate, 15m (AZD7594), that demonstrated an improved therapeutic ratio over the benchmark inhaled corticosteroid 3 (fluticasone propionate) and prolonged the inhibition of lung edema, indicating potential for once-daily treatment.

Ab initio calculations on bismuth polycationic species of the types Bi(n(n-2))+, Bi(n(n-4))+, and Bi(n(n-6))+ (n = 3 - 12) were performed at the Hartree-Fock and density functional theory levels in order to investigate their general properties and the applicability of Wade's rules on bismuth polycations. Some exceptions to Wade's rules were encountered, and, moreover, several predicted and calculated minima show only meta-stable behavior. The bonding in bismuth polycations is characterized by a high degree of electron delocalization and "three-dimensional aromaticity".

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Three salts containing different iodobismuthate anions have been synthesized. [(CH 3 ) 2 NH 2 ] 3 [BiI 6 ] was prepared by oxidation of bismuth by iodine in N,N-dimethylformamide. [(CH 3 ) 2 NH 2 ] 3 [BiI 6 ] crystallizes in the space group R3 with a ϭ 30.760(3) Å and c ϭ 8.8039(5) Å and contains monomeric [BiI 6 ] 3Ϫ anions. The hydrate Na 4 [Bi 2 I 10 ] · 14H 2 O was prepared by the oxidation of bismuth using iodine in acetonitrile in the presence of NaI. Na 4 [Bi 2 I 10 ] · 14H 2 O crystallizes in the space group C2/m with a ϭ 12.875(2) Å , b ϭ 16.177(2) Å , c ϭ 9.904(2) Å and β ϭ 106.57(6)°. The structure contains dimeric [Bi 2 I 10 ] 4Ϫ anions and

An almost perfect square‐antiprismatic geometry is observed for Sb82+ (see picture), as predicted by the Wade rules. The title compound, which was synthesized in benzene at room temperature, represents the first homopolyatomic antimony cation and has SbSb bond lengths of 285–300 pm.

Two new supramolecular complexes [Hg(6)As(4)](CrBr(6))Br (1) and [Hg(6)As(4)](FeBr(6))Hg(0.6) (2) have been prepared by the standard ampoule technique and their crystal structures determined. Both crystallize in the cubic space group Pa$\bar 3$ with the unit cell parameter a=12.275(1) (1) and 12.332(1) A (2), and Z=4. Their structures consist of bicompartmental, three-dimensional [Hg(6)As(4)](4+) frameworks with cavities of two different sizes occupied by guest anions of different type. The bigger cavities are filled with the octahedral MBr(6) (n-) ions (M=Cr or Fe; n=3 or 4), whereas the smaller cavities trap either Br- ions (1) or Hg(0) (2). The analysis of the host-guest contacts has allowed a classification of the octahedral guests as coordinated and the monatomic guests as clathrated. Magnetic measurements and ESR spectroscopy data have given information about the interaction between the host and guests. Band structure calculations (HF and hybrid DFT level) indicate that both 1 and 2 are non-metallic, with a band gap of approximately 1.5 eV (B3LYP), and that the interaction between the host and guests is of predominantly electrostatic character. It is shown that though the electrostatic host-guest interaction is weak it plays an important role in assembling the perfectly ordered supramolecular architectures.

A new bismuth subiodide Bi 16 I 4 was synthesized by hightemperature synthesis.